Project measure / variable:   Auwerx2   vo2_max_treadmill_HFD

ID, description, units MPD:114642   vo2_max_treadmill_HFD   maximum oxygen consumption, treadmill test   [ratio]  HFD  
Data set, strains Auwerx2   inbred w/CC8   9 strains     sex: both     age: 19wks
Procedure monitoring system
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  STRAIN COMPARISON PLOT
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Auwerx2 - maximum oxygen consumption, treadmill test HFD



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested9 strains9 strains
Mean of the strain means135.0   ratio 122.8   ratio
Median of the strain means127.9   ratio 107.0   ratio
SD of the strain means± 32.287 ± 32.019
Coefficient of variation (CV)0.2392 0.2608
Min–max range of strain means97.16   –   202.1   ratio 90.29   –   171.5   ratio
Mean sample size per strain4.4   mice 3.6   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 1268.8861 1268.8861 10.9029 0.0018
strain 7 47311.0226 6758.7175 58.0744 < 0.0001
sex:strain 7 7925.049 1132.1499 9.728 < 0.0001
Residuals 50 5819.0163 116.3803


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ f 127.9 2.8684   5 1.2828 0.0224 124.7, 132.1 -0.22
129S1/SvImJ m 101.6 1.2021   2   0.85 0.0118 100.7, 102.4 -0.66
A/J f 107.5 11.482   4 5.741 0.1068 93.41, 121.2 -0.85
A/J m 90.9 1.3076   5 0.58479 0.0144 88.71, 92.06 -1.0
C57BL/6J f 122.5 7.6173   3 4.3979 0.0622 114.4, 129.5 -0.39
C57BL/6J m 107.0 7.9568   3 4.5938 0.0744 100.9, 116.0 -0.49
CAST/EiJ f 168.0 20.582   5 9.2045 0.1225 143.2, 195.1 1.02
CAST/EiJ m 133.8 11.526   2   8.15 0.0861 125.7, 142.0 0.34
DBA/2J f 134.4 12.082   5 5.4033 0.0899 124.7, 150.8 -0.02
DBA/2J m 145.6 5.1072   5 2.284 0.0351 139.8, 149.5 0.71
NOD/ShiLtJ f 116.6 4.7635   6 1.9447 0.0409 108.0, 121.8 -0.57
NOD/ShiLtJ m 98.64 5.5059   5 2.4623 0.0558 92.47, 105.1 -0.75
NZO/HlLtJ f 97.16 2.5066   5 1.121 0.0258 93.63, 99.76 -1.17
NZO/HlLtJ m 90.29 0.0   1   0.0 0.0 90.29, 90.29 -1.01
PWK/PhJ f 138.8 4.8453   4 2.4226 0.0349 134.3, 144.3 0.12
PWK/PhJ m 171.5 21.761   5 9.732 0.1269 155.5, 209.0 1.52
WSB/EiJ f 202.1 4.3509   3 2.512 0.0215 197.8, 206.5 2.08
WSB/EiJ m 165.6 11.356   4 5.6781 0.0686 150.8, 178.5 1.34


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ f 127.86 4.8245274594 137.5503485902 118.1696514098
129S1/SvImJ m 101.55 7.6282477029 116.871786433 86.228213567
A/J f 107.4775 5.3939856793 118.3116390867 96.6433609133
A/J m 90.898 4.8245274594 100.5883485902 81.2076514098
C57BL/6J f 122.5333333333 6.2284381679 135.0435195696 110.0231470971
C57BL/6J m 107.0 6.2284381679 119.5101862363 94.4898137637
CAST/EiJ f 168.0 4.8245274594 177.6903485902 158.3096514098
CAST/EiJ m 133.85 7.6282477029 149.171786433 118.528213567
DBA/2J f 134.42 4.8245274594 144.1103485902 124.7296514098
DBA/2J m 145.64 4.8245274594 155.3303485902 135.9496514098
NOD/ShiLtJ f 116.55 4.4041708647 125.3960375216 107.7039624784
NOD/ShiLtJ m 98.642 4.8245274594 108.3323485902 88.9516514098
PWK/PhJ f 138.75 5.3939856793 149.5841390867 127.9158609133
PWK/PhJ m 171.52 4.8245274594 181.2103485902 161.8296514098
WSB/EiJ f 202.1 6.2284381679 214.6101862363 189.5898137637
WSB/EiJ m 165.55 5.3939856793 176.3841390867 154.7158609133


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ both 114.705 4.5129322016 123.7694910957 105.6405089043
A/J both 99.18775 3.6183955946 106.4555114426 91.9199885574
C57BL/6J both 114.7666666667 4.4041708647 123.6127041882 105.9206291451
CAST/EiJ both 150.925 4.5129322016 159.9894910957 141.8605089043
DBA/2J both 140.03 3.4114560826 146.8821112002 133.1778887998
NOD/ShiLtJ both 107.596 3.2662205304 114.1563970084 101.0356029916
PWK/PhJ both 155.135 3.6183955946 162.4027614426 147.8672385574
WSB/EiJ both 183.825 4.1197246121 192.0997104091 175.5502895909




  GWAS USING LINEAR MIXED MODELS