Project measure / variable:   Auwerx2   vo2_basal_HFD

ID, description, units MPD:114634   vo2_basal_HFD   basal oxygen consumption, prior to treadmill test   [mL/kg/min]  HFD  
Data set, strains Auwerx2   inbred w/CC8   9 strains     sex: both     age: 19wks
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  STRAIN COMPARISON PLOT
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Auwerx2 - basal oxygen consumption, prior to treadmill test HFD



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested9 strains9 strains
Mean of the strain means121.9   mL/kg/min 109.1   mL/kg/min
Median of the strain means123.9   mL/kg/min 105.8   mL/kg/min
SD of the strain means± 19.81 ± 18.725
Coefficient of variation (CV)0.1625 0.1716
Min–max range of strain means93.06   –   144.3   mL/kg/min 86.24   –   142.1   mL/kg/min
Mean sample size per strain4.4   mice 3.6   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 4077.0284 4077.0284 17.9055 < 0.0001
strain 7 18810.3619 2687.1946 11.8016 < 0.0001
sex:strain 7 1215.6639 173.6663 0.7627 0.6209
Residuals 50 11384.8395 227.6968


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ f 110.4 9.4494   5 4.2259 0.0856 95.4, 121.3 -0.58
129S1/SvImJ m 105.8 5.1619   2   3.65 0.0488 102.1, 109.4 -0.18
A/J f 103.4 8.7862   4 4.3931 0.0849 92.16, 110.9 -0.93
A/J m 86.24 10.626   5 4.7523 0.1232 69.32, 96.12 -1.22
C57BL/6J f 123.9 14.689   3 8.4808 0.1186 114.2, 140.8 0.1
C57BL/6J m 101.9 5.9862   3 3.4562 0.0587 98.14, 108.8 -0.39
CAST/EiJ f 138.8 15.618   5 6.9847 0.1125 117.7, 154.9 0.85
CAST/EiJ m 142.1 8.2731   2   5.85 0.0582 136.2, 147.9 1.76
DBA/2J f 140.3 9.7654   5 4.3672 0.0696 125.5, 148.5 0.93
DBA/2J m 120.6 8.9374   5 3.9969 0.0741 107.9, 129.1 0.61
NOD/ShiLtJ f 102.8 12.616   6 5.1506 0.1227 87.43, 117.9 -0.97
NOD/ShiLtJ m 86.4 9.5475   5 4.2698 0.1105 71.46, 95.33 -1.21
NZO/HlLtJ f 93.06 8.8772   5 3.97 0.0954 84.3, 105.8 -1.46
NZO/HlLtJ m 98.13 0.0   1   0.0 0.0 98.13, 98.13 -0.59
PWK/PhJ f 140.3 25.394   4 12.697 0.1809 116.9, 173.6 0.93
PWK/PhJ m 127.7 11.495   5 5.1409 0.09 117.8, 141.1 0.99
WSB/EiJ f 144.3 46.215   3 26.682 0.3203 98.07, 190.5 1.13
WSB/EiJ m 113.2 7.6182   4 3.8091 0.0673 102.8, 120.0 0.22


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ f 110.38 6.7482855591 123.9343304507 96.8256695493
129S1/SvImJ m 105.75 10.6699763339 127.1812781914 84.3187218086
A/J f 103.44 7.5448126208 118.5942021386 88.2857978614
A/J m 86.238 6.7482855591 99.7923304507 72.6836695493
C57BL/6J f 123.9 8.7119991952 141.3985653682 106.4014346318
C57BL/6J m 101.8966666667 8.7119991952 119.3952320349 84.3981012985
CAST/EiJ f 138.82 6.7482855591 152.3743304507 125.2656695493
CAST/EiJ m 142.05 10.6699763339 163.4812781914 120.6187218086
DBA/2J f 140.26 6.7482855591 153.8143304507 126.7056695493
DBA/2J m 120.64 6.7482855591 134.1943304507 107.0856695493
NOD/ShiLtJ f 102.815 6.1603137086 115.1883542329 90.4416457671
NOD/ShiLtJ m 86.4 6.7482855591 99.9543304507 72.8456695493
PWK/PhJ f 140.35 7.5448126208 155.5042021386 125.1957978614
PWK/PhJ m 127.72 6.7482855591 141.2743304507 114.1656695493
WSB/EiJ f 144.29 8.7119991952 161.7885653682 126.7914346318
WSB/EiJ m 113.25 7.5448126208 128.4042021386 98.0957978614


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ both 108.065 6.3124431275 120.7439151634 95.3860848366
A/J both 94.839 5.0612141693 105.004747838 84.673252162
C57BL/6J both 112.8983333333 6.1603137086 125.2716875662 100.5249791004
CAST/EiJ both 140.435 6.3124431275 153.1139151634 127.7560848366
DBA/2J both 130.45 4.7717584802 140.0343589761 120.8656410239
NOD/ShiLtJ both 94.6075 4.5686109206 103.7838250942 85.4311749058
PWK/PhJ both 134.035 5.0612141693 144.200747838 123.869252162
WSB/EiJ both 128.77 5.7624458232 140.3442130662 117.1957869338




  GWAS USING LINEAR MIXED MODELS