Project measure / variable:   Auwerx2   ogtt_gluc_t180_HFD

ID, description, units MPD:114600   ogtt_gluc_t180_HFD   glucose, glucose tolerance test (20% glucose oral gavage, overnight fast), after 180 min   [mg/dL]  HFD  
Data set, strains Auwerx2   inbred w/CC8   8 strains     sex: both     age: 16wks
Procedure glucose tolerance
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  STRAIN COMPARISON PLOT
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Auwerx2 - glucose, glucose tolerance test (20% glucose oral gavage, overnight fast), after 180 min HFD



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested8 strains8 strains
Mean of the strain means107.9   mg/dL 156.5   mg/dL
Median of the strain means108.5   mg/dL 154.5   mg/dL
SD of the strain means± 12.555 ± 31.455
Coefficient of variation (CV)0.1164 0.201
Min–max range of strain means85.2   –   127.7   mg/dL 112.4   –   206.5   mg/dL
Mean sample size per strain4.9   mice 4.1   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 33348.9608 33348.9608 16.4335 0.0002
strain 7 13934.1114 1990.5873 0.9809 0.4543
sex:strain 7 17209.5056 2458.5008 1.2115 0.3119
Residuals 56 113642.0333 2029.322


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ f 85.2 15.675   5 7.01 0.184 72.0, 112.0 -1.81
129S1/SvImJ m 129.0 53.74   2   38.0 0.4166 91.0, 167.0 -0.87
A/J f 101.2 7.719   4 3.8595 0.0762 92.0, 109.0 -0.53
A/J m 183.0 21.76   5 9.7314 0.1189 151.0, 211.0 0.84
C57BL/6J f 114.3 15.695   3 9.0615 0.1373 102.0, 132.0 0.51
C57BL/6J m 178.2 25.237   4 12.619 0.1416 148.0, 209.0 0.69
CAST/EiJ f 107.4 14.415   5 6.4467 0.1342 90.0, 128.0 -0.04
CAST/EiJ m 206.5 23.335   2   16.5 0.113 190.0, 223.0 1.59
DBA/2J f 116.2 2.9496   5 1.3191 0.0254 114.0, 121.0 0.66
DBA/2J m 151.4 25.53   5 11.418 0.1686 126.0, 194.0 -0.16
NOD/ShiLtJ f 127.7 98.64   10 31.191 0.7724 68.0, 399.0 1.58
NOD/ShiLtJ m 133.6 33.59   5 15.022 0.2514 108.0, 192.0 -0.73
PWK/PhJ f 109.5 13.772   4 6.886 0.1258 91.0, 123.0 0.13
PWK/PhJ m 112.4 14.046   5 6.2817 0.125 96.0, 129.0 -1.4
WSB/EiJ f 101.7 15.885   3 9.1712 0.1562 92.0, 120.0 -0.49
WSB/EiJ m 157.6 42.84   5 19.159 0.2718 94.0, 205.0 0.04


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ f 85.2 20.1460766593 125.5574410889 44.8425589111
129S1/SvImJ m 129.0 31.8537440799 192.8107171885 65.1892828115
A/J f 101.25 22.523998445 146.3709908364 56.1290091636
A/J m 183.0 20.1460766593 223.3574410889 142.6425589111
C57BL/6J f 114.3333333333 26.0084731309 166.4345657443 62.2321009224
C57BL/6J m 178.25 22.523998445 223.3709908364 133.1290091636
CAST/EiJ f 107.4 20.1460766593 147.7574410889 67.0425589111
CAST/EiJ m 206.5 31.8537440799 270.3107171885 142.6892828115
DBA/2J f 116.2 20.1460766593 156.5574410889 75.8425589111
DBA/2J m 151.4 20.1460766593 191.7574410889 111.0425589111
NOD/ShiLtJ f 127.7 14.2454274201 156.2370202653 99.1629797347
NOD/ShiLtJ m 133.6 20.1460766593 173.9574410889 93.2425589111
PWK/PhJ f 109.5 22.523998445 154.6209908364 64.3790091636
PWK/PhJ m 112.4 20.1460766593 152.7574410889 72.0425589111
WSB/EiJ f 101.6666666667 26.0084731309 153.7678990776 49.5654342557
WSB/EiJ m 157.6 20.1460766593 197.9574410889 117.2425589111


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ both 107.1 18.8449291367 144.8509293904 69.3490706096
A/J both 142.125 15.1095574945 172.3930808167 111.8569191833
C57BL/6J both 146.2916666667 17.2029879712 180.7533926565 111.8299406768
CAST/EiJ both 156.95 18.8449291367 194.7009293904 119.1990706096
DBA/2J both 133.8 14.2454274201 162.3370202653 105.2629797347
NOD/ShiLtJ both 130.65 12.3369020336 155.3637844981 105.9362155019
PWK/PhJ both 110.95 15.1095574945 141.2180808167 80.6819191833
WSB/EiJ both 129.6333333333 16.4492027114 162.5850459974 96.6816206692




  GWAS USING LINEAR MIXED MODELS