Project measure / variable:   Project1032   active_d10_cocaine

ID, description, units MPD:111485   active_d10_cocaine   number of active lever presses (during infusions and timeouts) (intravenous self administration), cocaine   [n]  day 10  
cocaine study
Data set, strains Project1032   HMDP   65 strains     sex: both     age: 9-15wks
Procedure operant conditioning chamber
Ontology mappings


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  STRAIN COMPARISON PLOT
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Project1032 - number of active lever presses (during infusions and timeouts) (intravenous self administration), cocaine day 10



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested61 strains62 strains
Mean of the strain means41.658   n 41.566   n
Median of the strain means38.0   n 38.5   n
SD of the strain means± 34.686 ± 24.222
Coefficient of variation (CV)0.8326 0.5827
Min–max range of strain means1.0   –   180.0   n 1.0   –   127.0   n
Mean sample size per strain2.2   mice 2.3   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 107.3059 107.3059 0.0763 0.7829
strain 33 67194.1991 2036.1879 1.4472 0.077
sex:strain 33 65725.3187 1991.6763 1.4156 0.0899
Residuals 122 171652.25 1406.9857


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
Select table page:
Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ m 74.5 16.263   2   11.5 0.2183 63.0, 86.0 1.36
129X1/SvJ f 41.0 0.0   1   0.0 0.0 41.0, 41.0 -0.02
129X1/SvJ m 1.0 0.0   2   0.0 0.0 1.0, 1.0 -1.67
A/J f 53.33 55.59   3 32.095 1.0423 3.0, 113.0 0.34
A/J m 5.0 1.4142   2   1.0 0.2828 4.0, 6.0 -1.51
AKR/J f 21.5 27.577   2   19.5 1.2827 2.0, 41.0 -0.58
AKR/J m 64.0 48.083   2   34.0 0.7513 30.0, 98.0 0.93
BALB/cByJ f 29.667 20.207   3 11.667 0.6811 8.0, 48.0 -0.35
BALB/cByJ m 16.667 10.214   3 5.8973 0.6129 5.0, 24.0 -1.03
BALB/cJ f 26.5 14.849   2   10.5 0.5603 16.0, 37.0 -0.44
BALB/cJ m 13.333 6.6583   3 3.8442 0.4994 9.0, 21.0 -1.17
BPL/1J f 159.3 132.3   3 76.36 0.8301 68.0, 311.0 3.39
BPL/1J m 29.0 11.533   3 6.6583 0.3977 20.0, 42.0 -0.52
BTBR T+ Itpr3tf/J f 8.0 0.0   1   0.0 0.0 8.0, 8.0 -0.97
BTBR T+ Itpr3tf/J m 1.3333 0.57735   3 0.33333 0.433 1.0, 2.0 -1.66
BXD100/RwwJ f 31.5 12.021   2   8.5 0.3816 23.0, 40.0 -0.29
BXD100/RwwJ m 49.0 0.0   1   0.0 0.0 49.0, 49.0 0.31
BXD11/TyJ f 1.5 0.70711   2   0.5 0.4714 1.0, 2.0 -1.16
BXD11/TyJ m 55.0 0.0   1   0.0 0.0 55.0, 55.0 0.55
BXD15/TyJ f 67.67 4.0415   3 2.3333 0.0597 64.0, 72.0 0.75
BXD15/TyJ m 48.0 0.0   1   0.0 0.0 48.0, 48.0 0.27
BXD1/TyJ f 67.0 0.0   1   0.0 0.0 67.0, 67.0 0.73
BXD1/TyJ m 44.0 29.462   3 17.01 0.6696 18.0, 76.0 0.1
BXD21/TyJ f 86.0 0.0   1   0.0 0.0 86.0, 86.0 1.28
BXD21/TyJ m 62.5 47.376   2   33.5 0.758 29.0, 96.0 0.86
BXD28/TyJ m 1.0 0.0   1   0.0 0.0 1.0, 1.0 -1.67
BXD2/TyJ f 42.333 17.098   3 9.8714 0.4039 31.0, 62.0 0.02
BXD2/TyJ m 67.33 17.559   3 10.138 0.2608 49.0, 84.0 1.06
BXD31/TyJ f 66.33 15.144   3 8.7433 0.2283 49.0, 77.0 0.71
BXD31/TyJ m 33.75 3.5   4 1.75 0.1037 30.0, 38.0 -0.32
BXD32/TyJ f 27.5 12.021   2   8.5 0.4371 19.0, 36.0 -0.41
BXD32/TyJ m 52.5 47.376   2   33.5 0.9024 19.0, 86.0 0.45
BXD34/TyJ f 14.5 0.70711   2   0.5 0.0488 14.0, 15.0 -0.78
BXD34/TyJ m 13.0 0.0   1   0.0 0.0 13.0, 13.0 -1.18
BXD38/TyJ f 48.333 16.623   3 9.5975 0.3439 33.0, 66.0 0.19
BXD38/TyJ m 44.333 11.15   3 6.4377 0.2515 36.0, 57.0 0.11
BXD39/TyJ f 14.0 0.0   1   0.0 0.0 14.0, 14.0 -0.8
BXD39/TyJ m 30.333 13.65   3 7.8811 0.45 21.0, 46.0 -0.46
BXD40/TyJ f 1.0 0.0   1   0.0 0.0 1.0, 1.0 -1.17
BXD40/TyJ m 48.5 0.70711   2   0.5 0.0146 48.0, 49.0 0.29
BXD42/TyJ f 35.5 13.435   2   9.5 0.3785 26.0, 45.0 -0.18
BXD42/TyJ m 55.33 18.009   3 10.398 0.3255 37.0, 73.0 0.57
BXD48a/RwwJ f 45.0 4.2426   2   3.0 0.0943 42.0, 48.0 0.1
BXD48a/RwwJ m 43.333 9.4516   3 5.4569 0.2181 36.0, 54.0 0.07
BXD50/RwwJ f 121.0 0.0   1   0.0 0.0 121.0, 121.0 2.29
BXD50/RwwJ m 25.0 15.556   2   11.0 0.6223 14.0, 36.0 -0.68
BXD55/RwwJ f 48.5 13.435   2   9.5 0.277 39.0, 58.0 0.2
BXD55/RwwJ m 36.0 0.0   1   0.0 0.0 36.0, 36.0 -0.23
BXD60/RwwJ f 53.0 0.0   1   0.0 0.0 53.0, 53.0 0.33
BXD60/RwwJ m 50.0 16.971   2   12.0 0.3394 38.0, 62.0 0.35
BXD61/RwwJ f 35.667 30.172   3 17.42 0.8459 1.0, 56.0 -0.17
BXD61/RwwJ m 40.0 0.0   1   0.0 0.0 40.0, 40.0 -0.06
BXD62/RwwJ f 32.0 5.1962   3 3.0 0.1624 26.0, 35.0 -0.28
BXD62/RwwJ m 49.0 2.8284   2   2.0 0.0577 47.0, 51.0 0.31
BXD63/RwwJ f 1.0 0.0   1   0.0 0.0 1.0, 1.0 -1.17
BXD63/RwwJ m 25.0 0.0   1   0.0 0.0 25.0, 25.0 -0.68
BXD65/RwwJ f 66.0 37.162   3 21.455 0.5631 27.0, 101.0 0.7
BXD65/RwwJ m 60.0 54.01   3 31.182 0.9002 1.0, 107.0 0.76
BXD68/RwwJ m 43.5 7.7782   2   5.5 0.1788 38.0, 49.0 0.08
BXD69/RwwJ f 46.5 2.1213   2   1.5 0.0456 45.0, 48.0 0.14
BXD70/RwwJ f 50.0 0.0   1   0.0 0.0 50.0, 50.0 0.24
BXD70/RwwJ m 71.0 0.0   1   0.0 0.0 71.0, 71.0 1.22
BXD71/RwwJ f 42.0 0.0   1   0.0 0.0 42.0, 42.0 0.01
BXD71/RwwJ m 20.0 19.799   2   14.0 0.9899 6.0, 34.0 -0.89
BXD73a/RwwJ f 39.0 8.4853   2   6.0 0.2176 33.0, 45.0 -0.08
BXD73a/RwwJ m 35.0 0.0   1   0.0 0.0 35.0, 35.0 -0.27
BXD75/RwwJ f 180.0 0.0   1   0.0 0.0 180.0, 180.0 3.99
BXD75/RwwJ m 37.0 19.799   2   14.0 0.5351 23.0, 51.0 -0.19
BXD77/RwwJ f 4.6667 4.6188   3 2.6667 0.9897 2.0, 10.0 -1.07
BXD77/RwwJ m 29.333 38.083   3 21.987 1.2983 3.0, 73.0 -0.51
BXD84/RwwJ f 6.6667 5.5076   3 3.1798 0.8261 3.0, 13.0 -1.01
BXD84/RwwJ m 56.0 64.09   3 37.0 1.1444 19.0, 130.0 0.6
BXD90/RwwJ m 86.5 77.07   2   54.5 0.891 32.0, 141.0 1.86
BXD98/RwwJ f 42.0 11.314   2   8.0 0.2694 34.0, 50.0 0.01
BXD98/RwwJ m 37.0 10.44   3 6.0277 0.2822 30.0, 49.0 -0.19
BXD99/RwwJ f 17.0 0.0   1   0.0 0.0 17.0, 17.0 -0.71
BXD99/RwwJ m 34.0 0.0   1   0.0 0.0 34.0, 34.0 -0.31
C3HeB/FeJ f 12.0 16.462   3 9.5044 1.3718 2.0, 31.0 -0.86
C3HeB/FeJ m 65.5 40.305   2   28.5 0.6153 37.0, 94.0 0.99
C3H/HeJ f 24.0 29.698   2   21.0 1.2374 3.0, 45.0 -0.51
C3H/HeJ m 24.333 37.846   3 21.851 1.5553 1.0, 68.0 -0.71
C57BL/10J f 42.0 35.384   3 20.429 0.8425 4.0, 74.0 0.01
C57BL/10J m 37.667 9.4516   3 5.4569 0.2509 27.0, 45.0 -0.16
C57BL/6J f 24.5 2.1213   2   1.5 0.0866 23.0, 26.0 -0.49
C57BL/6J m 39.333 8.0829   3 4.6667 0.2055 30.0, 44.0 -0.09
C57BLKS/J f 38.333 23.629   3 13.642 0.6164 20.0, 65.0 -0.1
C57BLKS/J m 15.333 23.116   3 13.346 1.5075 1.0, 42.0 -1.08
C57BR/cdJ f 66.0 13.115   3 7.5719 0.1987 54.0, 80.0 0.7
C57BR/cdJ m 45.0 1.7321   3 1.0 0.0385 44.0, 47.0 0.14
C57L/J f 117.0 0.0   1   0.0 0.0 117.0, 117.0 2.17
C57L/J m 83.33 44.106   3 25.465 0.5293 46.0, 132.0 1.72
C58/J f 83.67 47.248   3 27.278 0.5647 42.0, 135.0 1.21
C58/J m 45.0 23.065   3 13.317 0.5126 27.0, 71.0 0.14
CBA/J f 42.0 33.779   3 19.502 0.8043 3.0, 62.0 0.01
CBA/J m 30.333 4.1633   3 2.4037 0.1373 27.0, 35.0 -0.46
DBA/1J f 16.0 14.107   3 8.1445 0.8817 1.0, 29.0 -0.74
DBA/1J m 24.0 0.0   1   0.0 0.0 24.0, 24.0 -0.73
DBA/2J f 1.0 0.0   1   0.0 0.0 1.0, 1.0 -1.17
FVB/NJ f 13.5 17.678   2   12.5 1.3095 1.0, 26.0 -0.81
FVB/NJ m 15.0 15.1   3 8.7178 1.0066 1.0, 31.0 -1.1
I/LnJ f 47.0 8.4853   2   6.0 0.1805 41.0, 53.0 0.15
I/LnJ m 32.0 0.0   1   0.0 0.0 32.0, 32.0 -0.39
KK/HlJ f 31.333 26.388   3 15.235 0.8422 1.0, 49.0 -0.3
KK/HlJ m 109.7 81.88   3 47.273 0.7466 57.0, 204.0 2.81
LP/J f 15.0 0.0   1   0.0 0.0 15.0, 15.0 -0.77
LP/J m 28.0 11.314   2   8.0 0.4041 20.0, 36.0 -0.56
MA/MyJ f 52.0 13.748   3 7.9373 0.2644 40.0, 67.0 0.3
MA/MyJ m 62.0 37.242   3 21.502 0.6007 40.0, 105.0 0.84
MRL/MpJ f 31.333 27.61   3 15.941 0.8812 1.0, 55.0 -0.3
MRL/MpJ m 27.667 22.189   3 12.811 0.802 3.0, 46.0 -0.57
NOD/ShiLtJ f 33.667 14.012   3 8.0898 0.4162 18.0, 45.0 -0.23
NOD/ShiLtJ m 57.33 25.968   3 14.993 0.4529 29.0, 80.0 0.65
NZB/BlNJ f 17.5 23.335   2   16.5 1.3334 1.0, 34.0 -0.7
NZB/BlNJ m 25.0 25.357   3 14.64 1.0143 7.0, 54.0 -0.68
NZO/HlLtJ f 40.667 11.547   3 6.6667 0.2839 34.0, 54.0 -0.03
NZO/HlLtJ m 52.0 26.907   3 15.535 0.5174 30.0, 82.0 0.43
NZW/LacJ f 32.667 47.078   3 27.18 1.4412 4.0, 87.0 -0.26
NZW/LacJ m 18.5 24.749   2   17.5 1.3378 1.0, 36.0 -0.95
PL/J f 46.5 21.92   2   15.5 0.4714 31.0, 62.0 0.14
PL/J m 127.0 155.2   3 89.58 1.2217 10.0, 303.0 3.53
SJL/J f 3.0 0.0   1   0.0 0.0 3.0, 3.0 -1.11
SM/J f 38.0 9.6609   4 4.8305 0.2542 24.0, 46.0 -0.11
SM/J m 26.0 5.6569   4 2.8284 0.2176 22.0, 34.0 -0.64


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
A/J f 53.3333333333 21.6562974347 96.2041371035 10.4625295632
A/J m 5.0 26.5234392165 57.5057970499 -47.5057970499
AKR/J f 21.5 26.5234392165 74.0057970499 -31.0057970499
AKR/J m 64.0 26.5234392165 116.5057970499 11.4942029501
BALB/cByJ f 29.6666666667 21.6562974347 72.5374704368 -13.2041371035
BALB/cByJ m 16.6666666667 21.6562974347 59.5374704368 -26.2041371035
BALB/cJ f 26.5 26.5234392165 79.0057970499 -26.0057970499
BALB/cJ m 13.3333333333 21.6562974347 56.2041371035 -29.5374704368
BPL/1J f 159.3333333333 21.6562974347 202.2041371035 116.4625295632
BPL/1J m 29.0 21.6562974347 71.8708037702 -13.8708037702
BXD2/TyJ f 42.3333333333 21.6562974347 85.2041371035 -0.5374704368
BXD2/TyJ m 67.3333333333 21.6562974347 110.2041371035 24.4625295632
BXD31/TyJ f 66.3333333333 21.6562974347 109.2041371035 23.4625295632
BXD31/TyJ m 33.75 18.7549037303 70.8772051456 -3.3772051456
BXD32/TyJ f 27.5 26.5234392165 80.0057970499 -25.0057970499
BXD32/TyJ m 52.5 26.5234392165 105.0057970499 -0.0057970499
BXD38/TyJ f 48.3333333333 21.6562974347 91.2041371035 5.4625295632
BXD38/TyJ m 44.3333333333 21.6562974347 87.2041371035 1.4625295632
BXD42/TyJ f 35.5 26.5234392165 88.0057970499 -17.0057970499
BXD42/TyJ m 55.3333333333 21.6562974347 98.2041371035 12.4625295632
BXD48a/RwwJ f 45.0 26.5234392165 97.5057970499 -7.5057970499
BXD48a/RwwJ m 43.3333333333 21.6562974347 86.2041371035 0.4625295632
BXD62/RwwJ f 32.0 21.6562974347 74.8708037702 -10.8708037702
BXD62/RwwJ m 49.0 26.5234392165 101.5057970499 -3.5057970499
BXD65/RwwJ f 66.0 21.6562974347 108.8708037702 23.1291962298
BXD65/RwwJ m 60.0 21.6562974347 102.8708037702 17.1291962298
BXD77/RwwJ f 4.6666666667 21.6562974347 47.5374704368 -38.2041371035
BXD77/RwwJ m 29.3333333333 21.6562974347 72.2041371035 -13.5374704368
BXD84/RwwJ f 6.6666666667 21.6562974347 49.5374704368 -36.2041371035
BXD84/RwwJ m 56.0 21.6562974347 98.8708037702 13.1291962298
BXD98/RwwJ f 42.0 26.5234392165 94.5057970499 -10.5057970499
BXD98/RwwJ m 37.0 21.6562974347 79.8708037702 -5.8708037702
C3HeB/FeJ f 12.0 21.6562974347 54.8708037702 -30.8708037702
C3HeB/FeJ m 65.5 26.5234392165 118.0057970499 12.9942029501
C3H/HeJ f 24.0 26.5234392165 76.5057970499 -28.5057970499
C3H/HeJ m 24.3333333333 21.6562974347 67.2041371035 -18.5374704368
C57BL/10J f 42.0 21.6562974347 84.8708037702 -0.8708037702
C57BL/10J m 37.6666666667 21.6562974347 80.5374704368 -5.2041371035
C57BL/6J f 24.5 26.5234392165 77.0057970499 -28.0057970499
C57BL/6J m 39.3333333333 21.6562974347 82.2041371035 -3.5374704368
C57BLKS/J f 38.3333333333 21.6562974347 81.2041371035 -4.5374704368
C57BLKS/J m 15.3333333333 21.6562974347 58.2041371035 -27.5374704368
C57BR/cdJ f 66.0 21.6562974347 108.8708037702 23.1291962298
C57BR/cdJ m 45.0 21.6562974347 87.8708037702 2.1291962298
C58/J f 83.6666666667 21.6562974347 126.5374704368 40.7958628965
C58/J m 45.0 21.6562974347 87.8708037702 2.1291962298
CBA/J f 42.0 21.6562974347 84.8708037702 -0.8708037702
CBA/J m 30.3333333333 21.6562974347 73.2041371035 -12.5374704368
FVB/NJ f 13.5 26.5234392165 66.0057970499 -39.0057970499
FVB/NJ m 15.0 21.6562974347 57.8708037702 -27.8708037702
KK/HlJ f 31.3333333333 21.6562974347 74.2041371035 -11.5374704368
KK/HlJ m 109.6666666667 21.6562974347 152.5374704368 66.7958628965
MA/MyJ f 52.0 21.6562974347 94.8708037702 9.1291962298
MA/MyJ m 62.0 21.6562974347 104.8708037702 19.1291962298
MRL/MpJ f 31.3333333333 21.6562974347 74.2041371035 -11.5374704368
MRL/MpJ m 27.6666666667 21.6562974347 70.5374704368 -15.2041371035
NOD/ShiLtJ f 33.6666666667 21.6562974347 76.5374704368 -9.2041371035
NOD/ShiLtJ m 57.3333333333 21.6562974347 100.2041371035 14.4625295632
NZB/BlNJ f 17.5 26.5234392165 70.0057970499 -35.0057970499
NZB/BlNJ m 25.0 21.6562974347 67.8708037702 -17.8708037702
NZO/HlLtJ f 40.6666666667 21.6562974347 83.5374704368 -2.2041371035
NZO/HlLtJ m 52.0 21.6562974347 94.8708037702 9.1291962298
NZW/LacJ f 32.6666666667 21.6562974347 75.5374704368 -10.2041371035
NZW/LacJ m 18.5 26.5234392165 71.0057970499 -34.0057970499
PL/J f 46.5 26.5234392165 99.0057970499 -6.0057970499
PL/J m 127.0 21.6562974347 169.8708037702 84.1291962298
SM/J f 38.0 18.7549037303 75.1272051456 0.8727948544
SM/J m 26.0 18.7549037303 63.1272051456 -11.1272051456


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
A/J both 29.1666666667 17.1208063949 63.0590129256 -4.7256795923
AKR/J both 42.75 18.7549037303 79.8772051456 5.6227948544
BALB/cByJ both 23.1666666667 15.3133147715 53.4809027275 -7.1475693941
BALB/cJ both 19.9166666667 17.1208063949 53.8090129256 -13.9756795923
BPL/1J both 94.1666666667 15.3133147715 124.4809027275 63.8524306059
BXD2/TyJ both 54.8333333333 15.3133147715 85.1475693941 24.5190972725
BXD31/TyJ both 50.0416666667 14.3242943327 78.398037987 21.6852953463
BXD32/TyJ both 40.0 18.7549037303 77.1272051456 2.8727948544
BXD38/TyJ both 46.3333333333 15.3133147715 76.6475693941 16.0190972725
BXD42/TyJ both 45.4166666667 17.1208063949 79.3090129256 11.5243204077
BXD48a/RwwJ both 44.1666666667 17.1208063949 78.0590129256 10.2743204077
BXD62/RwwJ both 40.5 17.1208063949 74.392346259 6.607653741
BXD65/RwwJ both 63.0 15.3133147715 93.3142360608 32.6857639392
BXD77/RwwJ both 17.0 15.3133147715 47.3142360608 -13.3142360608
BXD84/RwwJ both 31.3333333333 15.3133147715 61.6475693941 1.0190972725
BXD98/RwwJ both 39.5 17.1208063949 73.392346259 5.607653741
C3HeB/FeJ both 38.75 17.1208063949 72.642346259 4.857653741
C3H/HeJ both 24.1666666667 17.1208063949 58.0590129256 -9.7256795923
C57BL/10J both 39.8333333333 15.3133147715 70.1475693941 9.5190972725
C57BL/6J both 31.9166666667 17.1208063949 65.8090129256 -1.9756795923
C57BLKS/J both 26.8333333333 15.3133147715 57.1475693941 -3.4809027275
C57BR/cdJ both 55.5 15.3133147715 85.8142360608 25.1857639392
C58/J both 64.3333333333 15.3133147715 94.6475693941 34.0190972725
CBA/J both 36.1666666667 15.3133147715 66.4809027275 5.8524306059
FVB/NJ both 14.25 17.1208063949 48.142346259 -19.642346259
KK/HlJ both 70.5 15.3133147715 100.8142360608 40.1857639392
MA/MyJ both 57.0 15.3133147715 87.3142360608 26.6857639392
MRL/MpJ both 29.5 15.3133147715 59.8142360608 -0.8142360608
NOD/ShiLtJ both 45.5 15.3133147715 75.8142360608 15.1857639392
NZB/BlNJ both 21.25 17.1208063949 55.142346259 -12.642346259
NZO/HlLtJ both 46.3333333333 15.3133147715 76.6475693941 16.0190972725
NZW/LacJ both 25.5833333333 17.1208063949 59.4756795923 -8.3090129256
PL/J both 86.75 17.1208063949 120.642346259 52.857653741
SM/J both 32.0 13.2617196082 58.252898525 5.747101475




  GWAS USING LINEAR MIXED MODELS