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Project measure / variable:   Project1032   active_d9_cocaine

ID, description, units MPD:111484   active_d9_cocaine   number of active lever presses (during infusions and timeouts) (intravenous self administration), cocaine   [n]  day 9  
cocaine study
Data set, strains Project1032   HMDP   65 strains     sex: both     age: 9-15wks
Procedure operant conditioning chamber
Ontology mappings


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  STRAIN COMPARISON PLOT
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Project1032 - number of active lever presses (during infusions and timeouts) (intravenous self administration), cocaine day 9



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested61 strains61 strains
Mean of the strain means39.136   n 42.97   n
Median of the strain means36.333   n 41.5   n
SD of the strain means± 30.788 ± 25.26
Coefficient of variation (CV)0.7867 0.5879
Min–max range of strain means1.0   –   182.7   n 1.0   –   117.3   n
Mean sample size per strain2.1   mice 2.3   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 1.4072 1.4072 0.0013 0.9712
strain 32 85603.6725 2675.1148 2.4814 0.0003
sex:strain 32 64831.8879 2025.9965 1.8793 0.0087
Residuals 109 117508.6667 1078.0612


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
Select table page:
Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ f 1.0 0.0   1   0.0 0.0 1.0, 1.0 -1.24
129S1/SvImJ m 102.0 32.527   2   23.0 0.3189 79.0, 125.0 2.34
129X1/SvJ f 58.0 0.0   1   0.0 0.0 58.0, 58.0 0.61
A/J f 27.667 12.741   3 7.356 0.4605 13.0, 36.0 -0.37
A/J m 4.0 0.0   1   0.0 0.0 4.0, 4.0 -1.54
AKR/J f 24.5 33.234   2   23.5 1.3565 1.0, 48.0 -0.48
AKR/J m 54.0 43.841   2   31.0 0.8119 23.0, 85.0 0.44
BALB/cByJ f 36.333 6.5064   3 3.7565 0.1791 30.0, 43.0 -0.09
BALB/cByJ m 22.333 17.898   3 10.333 0.8014 7.0, 42.0 -0.82
BALB/cJ f 31.5 9.1924   2   6.5 0.2918 25.0, 38.0 -0.25
BALB/cJ m 20.667 23.861   3 13.776 1.1546 4.0, 48.0 -0.88
BPL/1J f 182.7 95.27   3 55.0 0.5215 77.0, 262.0 4.66
BPL/1J m 28.333 9.609   3 5.5478 0.3391 18.0, 37.0 -0.58
BTBR T+ Itpr3tf/J f 2.5 0.70711   2   0.5 0.2828 2.0, 3.0 -1.19
BTBR T+ Itpr3tf/J m 2.5 0.70711   2   0.5 0.2828 2.0, 3.0 -1.6
BXD100/RwwJ f 32.0 9.8995   2   7.0 0.3094 25.0, 39.0 -0.23
BXD100/RwwJ m 61.0 0.0   1   0.0 0.0 61.0, 61.0 0.71
BXD11/TyJ f 2.0 1.4142   2   1.0 0.7071 1.0, 3.0 -1.21
BXD11/TyJ m 51.0 0.0   1   0.0 0.0 51.0, 51.0 0.32
BXD15/TyJ f 72.0 6.0   3 3.4641 0.0833 66.0, 78.0 1.07
BXD15/TyJ m 81.0 0.0   1   0.0 0.0 81.0, 81.0 1.51
BXD1/TyJ f 25.5 33.234   2   23.5 1.3033 2.0, 49.0 -0.44
BXD1/TyJ m 45.0 23.259   3 13.429 0.5169 20.0, 66.0 0.08
BXD21/TyJ f 69.0 0.0   1   0.0 0.0 69.0, 69.0 0.97
BXD21/TyJ m 55.0 32.527   2   23.0 0.5914 32.0, 78.0 0.48
BXD2/TyJ f 37.333 12.662   3 7.3106 0.3392 26.0, 51.0 -0.06
BXD2/TyJ m 104.3 58.62   3 33.844 0.5619 69.0, 172.0 2.43
BXD31/TyJ f 49.333 10.017   3 5.7831 0.203 38.0, 57.0 0.33
BXD31/TyJ m 45.5 23.014   4 11.507 0.5058 22.0, 77.0 0.1
BXD32/TyJ f 13.0 1.4142   2   1.0 0.1088 12.0, 14.0 -0.85
BXD32/TyJ m 72.0 14.142   2   10.0 0.1964 62.0, 82.0 1.15
BXD34/TyJ f 28.0 4.2426   2   3.0 0.1515 25.0, 31.0 -0.36
BXD34/TyJ m 17.0 0.0   1   0.0 0.0 17.0, 17.0 -1.03
BXD38/TyJ f 51.0 24.021   3 13.868 0.471 32.0, 78.0 0.39
BXD38/TyJ m 47.667 8.6217   3 4.9777 0.1809 40.0, 57.0 0.19
BXD39/TyJ f 14.0 0.0   1   0.0 0.0 14.0, 14.0 -0.82
BXD39/TyJ m 26.333 12.055   3 6.9602 0.4578 15.0, 39.0 -0.66
BXD40/TyJ m 59.5 23.335   2   16.5 0.3922 43.0, 76.0 0.65
BXD42/TyJ f 40.0 4.2426   2   3.0 0.1061 37.0, 43.0 0.03
BXD42/TyJ m 55.67 17.954   3 10.366 0.3225 42.0, 76.0 0.5
BXD48a/RwwJ f 43.0 25.456   2   18.0 0.592 25.0, 61.0 0.13
BXD48a/RwwJ m 52.67 19.757   3 11.407 0.3751 35.0, 74.0 0.38
BXD50/RwwJ f 40.0 0.0   1   0.0 0.0 40.0, 40.0 0.03
BXD50/RwwJ m 22.5 17.678   2   12.5 0.7857 10.0, 35.0 -0.81
BXD55/RwwJ f 59.5 0.70711   2   0.5 0.0119 59.0, 60.0 0.66
BXD55/RwwJ m 39.0 0.0   1   0.0 0.0 39.0, 39.0 -0.16
BXD56/RwwJ m 1.0 0.0   1   0.0 0.0 1.0, 1.0 -1.66
BXD60/RwwJ f 51.0 0.0   1   0.0 0.0 51.0, 51.0 0.39
BXD60/RwwJ m 49.5 13.435   2   9.5 0.2714 40.0, 59.0 0.26
BXD61/RwwJ f 31.0 25.357   3 14.64 0.818 2.0, 49.0 -0.26
BXD61/RwwJ m 51.0 0.0   1   0.0 0.0 51.0, 51.0 0.32
BXD62/RwwJ f 37.0 4.2426   2   3.0 0.1147 34.0, 40.0 -0.07
BXD62/RwwJ m 40.5 28.991   2   20.5 0.7158 20.0, 61.0 -0.1
BXD63/RwwJ m 17.0 0.0   1   0.0 0.0 17.0, 17.0 -1.03
BXD65/RwwJ f 104.0 13.077   3 7.5498 0.1257 89.0, 113.0 2.11
BXD65/RwwJ m 60.67 62.69   3 36.195 1.0334 1.0, 126.0 0.7
BXD68/RwwJ f 61.0 0.0   1   0.0 0.0 61.0, 61.0 0.71
BXD68/RwwJ m 86.5 65.76   2   46.5 0.7602 40.0, 133.0 1.72
BXD69/RwwJ f 106.5 64.35   2   45.5 0.6042 61.0, 152.0 2.19
BXD70/RwwJ f 5.0 0.0   1   0.0 0.0 5.0, 5.0 -1.11
BXD70/RwwJ m 44.0 59.4   2   42.0 1.3499 2.0, 86.0 0.04
BXD71/RwwJ f 30.0 0.0   1   0.0 0.0 30.0, 30.0 -0.3
BXD71/RwwJ m 18.5 24.749   2   17.5 1.3378 1.0, 36.0 -0.97
BXD73a/RwwJ f 41.5 14.849   2   10.5 0.3578 31.0, 52.0 0.08
BXD73a/RwwJ m 37.0 0.0   1   0.0 0.0 37.0, 37.0 -0.24
BXD75/RwwJ f 36.0 0.0   1   0.0 0.0 36.0, 36.0 -0.1
BXD75/RwwJ m 89.5 79.9   2   56.5 0.8928 33.0, 146.0 1.84
BXD77/RwwJ f 10.5 9.1924   2   6.5 0.8755 4.0, 17.0 -0.93
BXD77/RwwJ m 41.5 43.134   2   30.5 1.0394 11.0, 72.0 -0.06
BXD84/RwwJ f 6.6667 2.3094   3 1.3333 0.3464 4.0, 8.0 -1.05
BXD84/RwwJ m 27.0 16.703   3 9.6437 0.6186 12.0, 45.0 -0.63
BXD90/RwwJ m 74.5 53.03   2   37.5 0.7119 37.0, 112.0 1.25
BXD98/RwwJ f 48.5 21.92   2   15.5 0.452 33.0, 64.0 0.3
BXD98/RwwJ m 37.0 5.2915   3 3.0551 0.143 33.0, 43.0 -0.24
BXD99/RwwJ f 13.0 0.0   1   0.0 0.0 13.0, 13.0 -0.85
BXD99/RwwJ m 30.0 0.0   1   0.0 0.0 30.0, 30.0 -0.51
C3HeB/FeJ f 15.5 16.263   2   11.5 1.0493 4.0, 27.0 -0.77
C3HeB/FeJ m 50.0 5.6569   2   4.0 0.1131 46.0, 54.0 0.28
C3H/HeJ f 2.3333 2.3094   3 1.3333 0.9897 1.0, 5.0 -1.2
C3H/HeJ m 13.5 17.678   2   12.5 1.3095 1.0, 26.0 -1.17
C57BL/10J f 39.0 31.607   3 18.248 0.8104 6.0, 69.0 0.0
C57BL/10J m 24.333 5.6862   3 3.283 0.2337 18.0, 29.0 -0.74
C57BL/6J f 20.0 0.0   1   0.0 0.0 20.0, 20.0 -0.62
C57BL/6J m 23.333 17.559   3 10.138 0.7525 5.0, 40.0 -0.78
C57BLKS/J f 45.333 25.716   3 14.847 0.5673 16.0, 64.0 0.2
C57BLKS/J m 19.0 25.456   2   18.0 1.3398 1.0, 37.0 -0.95
C57BR/cdJ f 69.0 18.52   3 10.693 0.2684 50.0, 87.0 0.97
C57BR/cdJ m 47.333 14.224   3 8.2125 0.3005 31.0, 57.0 0.17
C57L/J f 89.0 0.0   1   0.0 0.0 89.0, 89.0 1.62
C57L/J m 48.333 10.017   3 5.7831 0.2072 38.0, 58.0 0.21
C58/J f 95.0 18.083   3 10.44 0.1903 78.0, 114.0 1.81
C58/J m 53.0 28.16   3 16.258 0.5313 32.0, 85.0 0.4
CBA/J f 41.667 34.933   3 20.169 0.8384 4.0, 73.0 0.08
CBA/J m 34.333 9.2916   3 5.3645 0.2706 24.0, 42.0 -0.34
DBA/1J f 14.333 11.93   3 6.888 0.8324 1.0, 24.0 -0.81
DBA/1J m 2.0 0.0   1   0.0 0.0 2.0, 2.0 -1.62
DBA/2J f 1.0 0.0   1   0.0 0.0 1.0, 1.0 -1.24
FVB/NJ f 33.0 0.0   1   0.0 0.0 33.0, 33.0 -0.2
FVB/NJ m 10.5 7.7782   2   5.5 0.7408 5.0, 16.0 -1.29
I/LnJ f 37.0 5.6569   2   4.0 0.1529 33.0, 41.0 -0.07
I/LnJ m 38.0 0.0   1   0.0 0.0 38.0, 38.0 -0.2
KK/HlJ f 38.0 1.4142   2   1.0 0.0372 37.0, 39.0 -0.04
KK/HlJ m 71.5 36.062   2   25.5 0.5044 46.0, 97.0 1.13
LP/J f 25.0 11.314   2   8.0 0.4525 17.0, 33.0 -0.46
LP/J m 30.0 19.799   2   14.0 0.66 16.0, 44.0 -0.51
MA/MyJ f 53.33 1.5275   3 0.88192 0.0286 52.0, 55.0 0.46
MA/MyJ m 54.0 23.643   3 13.65 0.4378 37.0, 81.0 0.44
MRL/MpJ f 35.5 23.335   2   16.5 0.6573 19.0, 52.0 -0.12
MRL/MpJ m 35.0 56.29   3 32.501 1.6084 2.0, 100.0 -0.32
NOD/ShiLtJ f 37.333 38.76   3 22.378 1.0382 7.0, 81.0 -0.06
NOD/ShiLtJ m 44.333 18.61   3 10.745 0.4198 27.0, 64.0 0.05
NZB/BlNJ f 15.0 0.0   1   0.0 0.0 15.0, 15.0 -0.78
NZB/BlNJ m 26.333 17.214   3 9.9387 0.6537 14.0, 46.0 -0.66
NZO/HlLtJ f 36.667 10.017   3 5.7831 0.2732 27.0, 47.0 -0.08
NZO/HlLtJ m 52.67 25.716   3 14.847 0.4883 34.0, 82.0 0.38
NZW/LacJ f 28.5 38.891   2   27.5 1.3646 1.0, 56.0 -0.35
NZW/LacJ m 27.0 22.539   3 13.013 0.8348 1.0, 41.0 -0.63
PL/J f 56.5 23.335   2   16.5 0.413 40.0, 73.0 0.56
PL/J m 117.3 137.6   3 79.44 1.1726 12.0, 273.0 2.94
SJL/J f 3.5 2.1213   2   1.5 0.6061 2.0, 5.0 -1.16
SM/J f 34.25 12.685   4 6.3426 0.3704 17.0, 47.0 -0.16
SM/J m 25.25 9.2511   4 4.6256 0.3664 19.0, 39.0 -0.7


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
AKR/J f 24.5 23.2170321325 70.5154028947 -21.5154028947
AKR/J m 54.0 23.2170321325 100.0154028947 7.9845971053
BALB/cByJ f 36.3333333333 18.9566273554 73.9047524669 -1.2380858002
BALB/cByJ m 22.3333333333 18.9566273554 59.9047524669 -15.2380858002
BALB/cJ f 31.5 23.2170321325 77.5154028947 -14.5154028947
BALB/cJ m 20.6666666667 18.9566273554 58.2380858002 -16.9047524669
BPL/1J f 182.6666666667 18.9566273554 220.2380858002 145.0952475331
BPL/1J m 28.3333333333 18.9566273554 65.9047524669 -9.2380858002
BTBR T+ Itpr3tf/J f 2.5 23.2170321325 48.5154028947 -43.5154028947
BTBR T+ Itpr3tf/J m 2.5 23.2170321325 48.5154028947 -43.5154028947
BXD1/TyJ f 25.5 23.2170321325 71.5154028947 -20.5154028947
BXD1/TyJ m 45.0 18.9566273554 82.5714191335 7.4285808665
BXD2/TyJ f 37.3333333333 18.9566273554 74.9047524669 -0.2380858002
BXD2/TyJ m 104.3333333333 18.9566273554 141.9047524669 66.7619141998
BXD31/TyJ f 49.3333333333 18.9566273554 86.9047524669 11.7619141998
BXD31/TyJ m 45.5 16.4169208599 78.0378034259 12.9621965741
BXD32/TyJ f 13.0 23.2170321325 59.0154028947 -33.0154028947
BXD32/TyJ m 72.0 23.2170321325 118.0154028947 25.9845971053
BXD38/TyJ f 51.0 18.9566273554 88.5714191335 13.4285808665
BXD38/TyJ m 47.6666666667 18.9566273554 85.2380858002 10.0952475331
BXD42/TyJ f 40.0 23.2170321325 86.0154028947 -6.0154028947
BXD42/TyJ m 55.6666666667 18.9566273554 93.2380858002 18.0952475331
BXD48a/RwwJ f 43.0 23.2170321325 89.0154028947 -3.0154028947
BXD48a/RwwJ m 52.6666666667 18.9566273554 90.2380858002 15.0952475331
BXD62/RwwJ f 37.0 23.2170321325 83.0154028947 -9.0154028947
BXD62/RwwJ m 40.5 23.2170321325 86.5154028947 -5.5154028947
BXD65/RwwJ f 104.0 18.9566273554 141.5714191335 66.4285808665
BXD65/RwwJ m 60.6666666667 18.9566273554 98.2380858002 23.0952475331
BXD77/RwwJ f 10.5 23.2170321325 56.5154028947 -35.5154028947
BXD77/RwwJ m 41.5 23.2170321325 87.5154028947 -4.5154028947
BXD84/RwwJ f 6.6666666667 18.9566273554 44.2380858002 -30.9047524669
BXD84/RwwJ m 27.0 18.9566273554 64.5714191335 -10.5714191335
BXD98/RwwJ f 48.5 23.2170321325 94.5154028947 2.4845971053
BXD98/RwwJ m 37.0 18.9566273554 74.5714191335 -0.5714191335
C3HeB/FeJ f 15.5 23.2170321325 61.5154028947 -30.5154028947
C3HeB/FeJ m 50.0 23.2170321325 96.0154028947 3.9845971053
C3H/HeJ f 2.3333333333 18.9566273554 39.9047524669 -35.2380858002
C3H/HeJ m 13.5 23.2170321325 59.5154028947 -32.5154028947
C57BL/10J f 39.0 18.9566273554 76.5714191335 1.4285808665
C57BL/10J m 24.3333333333 18.9566273554 61.9047524669 -13.2380858002
C57BLKS/J f 45.3333333333 18.9566273554 82.9047524669 7.7619141998
C57BLKS/J m 19.0 23.2170321325 65.0154028947 -27.0154028947
C57BR/cdJ f 69.0 18.9566273554 106.5714191335 31.4285808665
C57BR/cdJ m 47.3333333333 18.9566273554 84.9047524669 9.7619141998
C58/J f 95.0 18.9566273554 132.5714191335 57.4285808665
C58/J m 53.0 18.9566273554 90.5714191335 15.4285808665
CBA/J f 41.6666666667 18.9566273554 79.2380858002 4.0952475331
CBA/J m 34.3333333333 18.9566273554 71.9047524669 -3.2380858002
KK/HlJ f 38.0 23.2170321325 84.0154028947 -8.0154028947
KK/HlJ m 71.5 23.2170321325 117.5154028947 25.4845971053
LP/J f 25.0 23.2170321325 71.0154028947 -21.0154028947
LP/J m 30.0 23.2170321325 76.0154028947 -16.0154028947
MA/MyJ f 53.3333333333 18.9566273554 90.9047524669 15.7619141998
MA/MyJ m 54.0 18.9566273554 91.5714191335 16.4285808665
MRL/MpJ f 35.5 23.2170321325 81.5154028947 -10.5154028947
MRL/MpJ m 35.0 18.9566273554 72.5714191335 -2.5714191335
NOD/ShiLtJ f 37.3333333333 18.9566273554 74.9047524669 -0.2380858002
NOD/ShiLtJ m 44.3333333333 18.9566273554 81.9047524669 6.7619141998
NZO/HlLtJ f 36.6666666667 18.9566273554 74.2380858002 -0.9047524669
NZO/HlLtJ m 52.6666666667 18.9566273554 90.2380858002 15.0952475331
NZW/LacJ f 28.5 23.2170321325 74.5154028947 -17.5154028947
NZW/LacJ m 27.0 18.9566273554 64.5714191335 -10.5714191335
PL/J f 56.5 23.2170321325 102.5154028947 10.4845971053
PL/J m 117.3333333333 18.9566273554 154.9047524669 79.7619141998
SM/J f 34.25 16.4169208599 66.7878034259 1.7121965741
SM/J m 25.25 16.4169208599 57.7878034259 -7.2878034259


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
AKR/J both 39.25 16.4169208599 71.7878034259 6.7121965741
BALB/cByJ both 29.3333333333 13.4043597515 55.9003385815 2.7663280852
BALB/cJ both 26.0833333333 14.9865297996 55.78614818 -3.6194815134
BPL/1J both 105.5 13.4043597515 132.0670052481 78.9329947519
BTBR T+ Itpr3tf/J both 2.5 16.4169208599 35.0378034259 -30.0378034259
BXD1/TyJ both 35.25 14.9865297996 64.9528148467 5.5471851533
BXD2/TyJ both 70.8333333333 13.4043597515 97.4003385815 44.2663280852
BXD31/TyJ both 47.4166666667 12.5386304198 72.2678245244 22.5655088089
BXD32/TyJ both 42.5 16.4169208599 75.0378034259 9.9621965741
BXD38/TyJ both 49.3333333333 13.4043597515 75.9003385815 22.7663280852
BXD42/TyJ both 47.8333333333 14.9865297996 77.53614818 18.1305184866
BXD48a/RwwJ both 47.8333333333 14.9865297996 77.53614818 18.1305184866
BXD62/RwwJ both 38.75 16.4169208599 71.2878034259 6.2121965741
BXD65/RwwJ both 82.3333333333 13.4043597515 108.9003385815 55.7663280852
BXD77/RwwJ both 26.0 16.4169208599 58.5378034259 -6.5378034259
BXD84/RwwJ both 16.8333333333 13.4043597515 43.4003385815 -9.7336719148
BXD98/RwwJ both 42.75 14.9865297996 72.4528148467 13.0471851533
C3HeB/FeJ both 32.75 16.4169208599 65.2878034259 0.2121965741
C3H/HeJ both 7.9166666667 14.9865297996 37.6194815134 -21.78614818
C57BL/10J both 31.6666666667 13.4043597515 58.2336719148 5.0996614185
C57BLKS/J both 32.1666666667 14.9865297996 61.8694815134 2.46385182
C57BR/cdJ both 58.1666666667 13.4043597515 84.7336719148 31.5996614185
C58/J both 74.0 13.4043597515 100.5670052481 47.4329947519
CBA/J both 38.0 13.4043597515 64.5670052481 11.4329947519
KK/HlJ both 54.75 16.4169208599 87.2878034259 22.2121965741
LP/J both 27.5 16.4169208599 60.0378034259 -5.0378034259
MA/MyJ both 53.6666666667 13.4043597515 80.2336719148 27.0996614185
MRL/MpJ both 35.25 14.9865297996 64.9528148467 5.5471851533
NOD/ShiLtJ both 40.8333333333 13.4043597515 67.4003385815 14.2663280852
NZO/HlLtJ both 44.6666666667 13.4043597515 71.2336719148 18.0996614185
NZW/LacJ both 27.75 14.9865297996 57.4528148467 -1.9528148467
PL/J both 86.9166666667 14.9865297996 116.6194815134 57.21385182
SM/J both 29.75 11.6085160662 52.7577014474 6.7422985526




  GWAS USING LINEAR MIXED MODELS