Project measure / variable:   Project1032   active_d6_cocaine

ID, description, units MPD:111481   active_d6_cocaine   number of active lever presses (during infusions and timeouts) (intravenous self administration), cocaine   [n]  day 6  
cocaine study
Data set, strains Project1032   HMDP   64 strains     sex: both     age: 9-15wks
Procedure operant conditioning chamber
Ontology mappings


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  STRAIN COMPARISON PLOT
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Project1032 - number of active lever presses (during infusions and timeouts) (intravenous self administration), cocaine day 6



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested60 strains60 strains
Mean of the strain means34.051   n 37.534   n
Median of the strain means31.0   n 34.833   n
SD of the strain means± 27.042 ± 23.914
Coefficient of variation (CV)0.7942 0.6371
Min–max range of strain means1.0   –   120.7   n 1.0   –   113.3   n
Mean sample size per strain2.2   mice 2.3   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 129.5213 129.5213 0.1072 0.7439
strain 29 55057.0721 1898.5197 1.5718 0.0497
sex:strain 29 60304.1331 2079.4529 1.7216 0.0237
Residuals 110 132867.75 1207.8886


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
Select table page:
Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ m 65.5 17.678   2   12.5 0.2699 53.0, 78.0 1.17
129X1/SvJ f 8.5 10.607   2   7.5 1.2478 1.0, 16.0 -0.94
A/J f 25.333 28.572   3 16.496 1.1278 5.0, 58.0 -0.32
A/J m 2.0 1.0   3 0.57735 0.5 1.0, 3.0 -1.49
AKR/J f 9.0 13.0   3 7.5056 1.4444 1.0, 24.0 -0.93
AKR/J m 25.0 0.0   2   0.0 0.0 25.0, 25.0 -0.52
BALB/cByJ f 44.333 39.804   3 22.981 0.8978 17.0, 90.0 0.38
BALB/cByJ m 25.333 4.9329   3 2.848 0.1947 22.0, 31.0 -0.51
BALB/cJ f 29.0 24.98   3 14.422 0.8614 1.0, 49.0 -0.19
BALB/cJ m 51.33 72.5   3 41.858 1.4123 7.0, 135.0 0.58
BPL/1J f 120.7 96.51   3 55.72 0.7998 25.0, 218.0 3.2
BPL/1J m 22.333 23.18   3 13.383 1.0379 7.0, 49.0 -0.64
BTBR T+ Itpr3tf/J f 8.0 0.0   1   0.0 0.0 8.0, 8.0 -0.96
BTBR T+ Itpr3tf/J m 1.0 0.0   1   0.0 0.0 1.0, 1.0 -1.53
BXD100/RwwJ f 8.5 2.1213   2   1.5 0.2496 7.0, 10.0 -0.94
BXD100/RwwJ m 33.0 0.0   1   0.0 0.0 33.0, 33.0 -0.19
BXD11/TyJ f 1.0 0.0   1   0.0 0.0 1.0, 1.0 -1.22
BXD11/TyJ m 15.5 20.506   2   14.5 1.323 1.0, 30.0 -0.92
BXD15/TyJ f 64.0 9.6437   3 5.5678 0.1507 57.0, 75.0 1.11
BXD15/TyJ m 46.0 0.0   1   0.0 0.0 46.0, 46.0 0.35
BXD1/TyJ f 51.0 0.0   1   0.0 0.0 51.0, 51.0 0.63
BXD1/TyJ m 43.0 17.521   3 10.116 0.4075 25.0, 60.0 0.23
BXD21/TyJ f 69.0 0.0   1   0.0 0.0 69.0, 69.0 1.29
BXD21/TyJ m 69.5 17.678   2   12.5 0.2544 57.0, 82.0 1.34
BXD2/TyJ f 32.333 21.385   3 12.347 0.6614 19.0, 57.0 -0.06
BXD2/TyJ m 113.3 31.214   3 18.022 0.2754 79.0, 140.0 3.17
BXD31/TyJ f 53.67 23.459   3 13.544 0.4371 28.0, 74.0 0.73
BXD31/TyJ m 26.0 13.491   4 6.7454 0.5189 6.0, 35.0 -0.48
BXD32/TyJ f 97.0 0.0   1   0.0 0.0 97.0, 97.0 2.33
BXD32/TyJ m 26.333 25.775   3 14.881 0.9788 3.0, 54.0 -0.47
BXD34/TyJ f 19.0 7.0711   2   5.0 0.3722 14.0, 24.0 -0.56
BXD38/TyJ f 46.667 19.14   3 11.05 0.4101 31.0, 68.0 0.47
BXD38/TyJ m 56.0 15.0   3 8.6603 0.2679 41.0, 71.0 0.77
BXD39/TyJ m 13.0 12.288   3 7.0946 0.9452 4.0, 27.0 -1.03
BXD40/TyJ f 1.0 0.0   1   0.0 0.0 1.0, 1.0 -1.22
BXD40/TyJ m 38.0 50.91   2   36.0 1.3398 2.0, 74.0 0.02
BXD42/TyJ f 53.0 29.698   2   21.0 0.5603 32.0, 74.0 0.7
BXD42/TyJ m 52.33 4.5092   3 2.6034 0.0862 48.0, 57.0 0.62
BXD48a/RwwJ f 30.0 25.12   3 14.503 0.8373 1.0, 45.0 -0.15
BXD48a/RwwJ m 35.667 9.5044   3 5.4874 0.2665 26.0, 45.0 -0.08
BXD50/RwwJ f 5.0 0.0   1   0.0 0.0 5.0, 5.0 -1.07
BXD50/RwwJ m 25.5 16.263   2   11.5 0.6378 14.0, 37.0 -0.5
BXD55/RwwJ f 66.5 36.062   2   25.5 0.5423 41.0, 92.0 1.2
BXD55/RwwJ m 39.0 0.0   1   0.0 0.0 39.0, 39.0 0.06
BXD60/RwwJ f 51.0 0.0   1   0.0 0.0 51.0, 51.0 0.63
BXD60/RwwJ m 44.5 20.506   2   14.5 0.4608 30.0, 59.0 0.29
BXD61/RwwJ f 18.0 18.33   3 10.583 1.0184 2.0, 38.0 -0.59
BXD61/RwwJ m 53.0 0.0   1   0.0 0.0 53.0, 53.0 0.65
BXD62/RwwJ f 10.5 9.1924   2   6.5 0.8755 4.0, 17.0 -0.87
BXD62/RwwJ m 30.5 34.648   2   24.5 1.136 6.0, 55.0 -0.29
BXD63/RwwJ m 4.0 0.0   1   0.0 0.0 4.0, 4.0 -1.4
BXD65/RwwJ f 98.67 49.054   3 28.322 0.4972 51.0, 149.0 2.39
BXD65/RwwJ m 35.333 27.154   3 15.677 0.7685 10.0, 64.0 -0.09
BXD68/RwwJ f 4.0 0.0   1   0.0 0.0 4.0, 4.0 -1.11
BXD68/RwwJ m 42.0 1.4142   2   1.0 0.0337 41.0, 43.0 0.19
BXD69/RwwJ f 43.0 2.8284   2   2.0 0.0658 41.0, 45.0 0.33
BXD70/RwwJ f 5.0 0.0   1   0.0 0.0 5.0, 5.0 -1.07
BXD70/RwwJ m 62.0 0.0   1   0.0 0.0 62.0, 62.0 1.02
BXD71/RwwJ f 32.0 0.0   1   0.0 0.0 32.0, 32.0 -0.08
BXD71/RwwJ m 23.5 17.678   2   12.5 0.7522 11.0, 36.0 -0.59
BXD73a/RwwJ f 39.5 7.7782   2   5.5 0.1969 34.0, 45.0 0.2
BXD73a/RwwJ m 38.0 0.0   1   0.0 0.0 38.0, 38.0 0.02
BXD75/RwwJ f 59.0 0.0   1   0.0 0.0 59.0, 59.0 0.92
BXD75/RwwJ m 40.5 13.435   2   9.5 0.3317 31.0, 50.0 0.12
BXD77/RwwJ f 43.0 0.0   1   0.0 0.0 43.0, 43.0 0.33
BXD77/RwwJ m 26.0 38.974   3 22.502 1.499 3.0, 71.0 -0.48
BXD84/RwwJ f 19.0 26.058   3 15.044 1.3715 2.0, 49.0 -0.56
BXD84/RwwJ m 30.333 11.372   3 6.5659 0.3749 21.0, 43.0 -0.3
BXD90/RwwJ m 78.5 55.86   2   39.5 0.7116 39.0, 118.0 1.71
BXD98/RwwJ f 62.5 6.364   2   4.5 0.1018 58.0, 67.0 1.05
BXD98/RwwJ m 34.333 9.2376   3 5.3333 0.2691 29.0, 45.0 -0.13
BXD99/RwwJ f 21.0 0.0   1   0.0 0.0 21.0, 21.0 -0.48
BXD99/RwwJ m 50.0 0.0   1   0.0 0.0 50.0, 50.0 0.52
C3HeB/FeJ f 9.6667 15.011   3 8.6667 1.5529 1.0, 27.0 -0.9
C3HeB/FeJ m 94.5 99.7   2   70.5 1.055 24.0, 165.0 2.38
C3H/HeJ f 3.0 0.0   1   0.0 0.0 3.0, 3.0 -1.15
C3H/HeJ m 8.3333 11.015   3 6.3596 1.3218 1.0, 21.0 -1.22
C57BL/10J f 50.67 37.687   3 21.759 0.7438 11.0, 86.0 0.61
C57BL/10J m 27.0 10.0   3 5.7735 0.3704 17.0, 37.0 -0.44
C57BL/6J f 14.333 23.094   3 13.333 1.6112 1.0, 41.0 -0.73
C57BL/6J m 39.0 6.0828   3 3.5119 0.156 32.0, 43.0 0.06
C57BLKS/J f 43.5 10.607   2   7.5 0.2438 36.0, 51.0 0.35
C57BLKS/J m 13.0 12.728   2   9.0 0.9791 4.0, 22.0 -1.03
C57BR/cdJ f 60.0 15.133   3 8.7369 0.2522 48.0, 77.0 0.96
C57BR/cdJ m 46.667 4.9329   3 2.848 0.1057 41.0, 50.0 0.38
C57L/J f 67.0 0.0   1   0.0 0.0 67.0, 67.0 1.22
C57L/J m 56.33 12.741   3 7.356 0.2262 48.0, 71.0 0.79
C58/J f 60.33 22.546   3 13.017 0.3737 37.0, 82.0 0.97
C58/J m 49.667 34.152   3 19.717 0.6876 20.0, 87.0 0.51
CBA/J f 14.333 20.551   3 11.865 1.4338 1.0, 38.0 -0.73
CBA/J m 16.667 16.773   3 9.6839 1.0064 6.0, 36.0 -0.87
DBA/1J f 9.6667 4.9329   3 2.848 0.5103 4.0, 13.0 -0.9
DBA/1J m 14.0 0.0   1   0.0 0.0 14.0, 14.0 -0.98
DBA/2J f 1.0 0.0   1   0.0 0.0 1.0, 1.0 -1.22
FVB/NJ f 8.0 9.8995   2   7.0 1.2374 1.0, 15.0 -0.96
FVB/NJ m 6.0 0.0   1   0.0 0.0 6.0, 6.0 -1.32
I/LnJ f 38.0 28.284   2   20.0 0.7443 18.0, 58.0 0.15
I/LnJ m 34.0 0.0   1   0.0 0.0 34.0, 34.0 -0.15
KK/HlJ f 19.667 16.921   3 9.7696 0.8604 1.0, 34.0 -0.53
KK/HlJ m 55.0 26.963   3 15.567 0.4902 37.0, 86.0 0.73
LP/J f 7.0 2.8284   2   2.0 0.4041 5.0, 9.0 -1.0
LP/J m 21.0 19.799   2   14.0 0.9428 7.0, 35.0 -0.69
MA/MyJ f 64.33 15.567   3 8.9876 0.242 48.0, 79.0 1.12
MA/MyJ m 54.67 15.044   3 8.6859 0.2752 45.0, 72.0 0.72
MRL/MpJ f 29.0 28.0   3 16.166 0.9655 1.0, 57.0 -0.19
MRL/MpJ m 20.333 31.754   3 18.333 1.5617 2.0, 57.0 -0.72
NOD/ShiLtJ f 59.33 33.561   3 19.376 0.5656 22.0, 87.0 0.93
NOD/ShiLtJ m 55.0 33.601   3 19.399 0.6109 20.0, 87.0 0.73
NZB/BlNJ f 5.5 6.364   2   4.5 1.1571 1.0, 10.0 -1.06
NZB/BlNJ m 22.0 24.042   2   17.0 1.0928 5.0, 39.0 -0.65
NZO/HlLtJ f 34.333 13.051   3 7.5351 0.3801 24.0, 49.0 0.01
NZO/HlLtJ m 41.0 12.53   3 7.2342 0.3056 29.0, 54.0 0.14
NZW/LacJ f 40.667 57.62   3 33.268 1.4169 3.0, 107.0 0.24
NZW/LacJ m 23.0 0.0   1   0.0 0.0 23.0, 23.0 -0.61
PL/J f 21.0 26.87   2   19.0 1.2795 2.0, 40.0 -0.48
PL/J m 112.0 149.5   3 86.32 1.3348 1.0, 282.0 3.11
SJL/J f 1.0 0.0   1   0.0 0.0 1.0, 1.0 -1.22
SJL/J m 1.0 0.0   2   0.0 0.0 1.0, 1.0 -1.53
SM/J f 33.0 5.5976   4 2.7988 0.1696 28.0, 41.0 -0.04
SM/J m 24.75 11.471   4 5.7355 0.4635 13.0, 40.0 -0.53


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
A/J f 25.3333333333 20.0656309508 65.0987041158 -14.4320374491
A/J m 2.0 20.0656309508 41.7653707824 -37.7653707824
AKR/J f 9.0 20.0656309508 48.7653707824 -30.7653707824
AKR/J m 25.0 24.5752785983 73.7024339248 -23.7024339248
BALB/cByJ f 44.3333333333 20.0656309508 84.0987041158 4.5679625509
BALB/cByJ m 25.3333333333 20.0656309508 65.0987041158 -14.4320374491
BALB/cJ f 29.0 20.0656309508 68.7653707824 -10.7653707824
BALB/cJ m 51.3333333333 20.0656309508 91.0987041158 11.5679625509
BPL/1J f 120.6666666667 20.0656309508 160.4320374491 80.9012958842
BPL/1J m 22.3333333333 20.0656309508 62.0987041158 -17.4320374491
BXD2/TyJ f 32.3333333333 20.0656309508 72.0987041158 -7.4320374491
BXD2/TyJ m 113.3333333333 20.0656309508 153.0987041158 73.5679625509
BXD31/TyJ f 53.6666666667 20.0656309508 93.4320374491 13.9012958842
BXD31/TyJ m 26.0 17.3773461464 60.4378212885 -8.4378212885
BXD38/TyJ f 46.6666666667 20.0656309508 86.4320374491 6.9012958842
BXD38/TyJ m 56.0 20.0656309508 95.7653707824 16.2346292176
BXD42/TyJ f 53.0 24.5752785983 101.7024339248 4.2975660752
BXD42/TyJ m 52.3333333333 20.0656309508 92.0987041158 12.5679625509
BXD48a/RwwJ f 30.0 20.0656309508 69.7653707824 -9.7653707824
BXD48a/RwwJ m 35.6666666667 20.0656309508 75.4320374491 -4.0987041158
BXD62/RwwJ f 10.5 24.5752785983 59.2024339248 -38.2024339248
BXD62/RwwJ m 30.5 24.5752785983 79.2024339248 -18.2024339248
BXD65/RwwJ f 98.6666666667 20.0656309508 138.4320374491 58.9012958842
BXD65/RwwJ m 35.3333333333 20.0656309508 75.0987041158 -4.4320374491
BXD84/RwwJ f 19.0 20.0656309508 58.7653707824 -20.7653707824
BXD84/RwwJ m 30.3333333333 20.0656309508 70.0987041158 -9.4320374491
BXD98/RwwJ f 62.5 24.5752785983 111.2024339248 13.7975660752
BXD98/RwwJ m 34.3333333333 20.0656309508 74.0987041158 -5.4320374491
C3HeB/FeJ f 9.6666666667 20.0656309508 49.4320374491 -30.0987041158
C3HeB/FeJ m 94.5 24.5752785983 143.2024339248 45.7975660752
C57BL/10J f 50.6666666667 20.0656309508 90.4320374491 10.9012958842
C57BL/10J m 27.0 20.0656309508 66.7653707824 -12.7653707824
C57BL/6J f 14.3333333333 20.0656309508 54.0987041158 -25.4320374491
C57BL/6J m 39.0 20.0656309508 78.7653707824 -0.7653707824
C57BLKS/J f 43.5 24.5752785983 92.2024339248 -5.2024339248
C57BLKS/J m 13.0 24.5752785983 61.7024339248 -35.7024339248
C57BR/cdJ f 60.0 20.0656309508 99.7653707824 20.2346292176
C57BR/cdJ m 46.6666666667 20.0656309508 86.4320374491 6.9012958842
C58/J f 60.3333333333 20.0656309508 100.0987041158 20.5679625509
C58/J m 49.6666666667 20.0656309508 89.4320374491 9.9012958842
CBA/J f 14.3333333333 20.0656309508 54.0987041158 -25.4320374491
CBA/J m 16.6666666667 20.0656309508 56.4320374491 -23.0987041158
KK/HlJ f 19.6666666667 20.0656309508 59.4320374491 -20.0987041158
KK/HlJ m 55.0 20.0656309508 94.7653707824 15.2346292176
LP/J f 7.0 24.5752785983 55.7024339248 -41.7024339248
LP/J m 21.0 24.5752785983 69.7024339248 -27.7024339248
MA/MyJ f 64.3333333333 20.0656309508 104.0987041158 24.5679625509
MA/MyJ m 54.6666666667 20.0656309508 94.4320374491 14.9012958842
MRL/MpJ f 29.0 20.0656309508 68.7653707824 -10.7653707824
MRL/MpJ m 20.3333333333 20.0656309508 60.0987041158 -19.4320374491
NOD/ShiLtJ f 59.3333333333 20.0656309508 99.0987041158 19.5679625509
NOD/ShiLtJ m 55.0 20.0656309508 94.7653707824 15.2346292176
NZB/BlNJ f 5.5 24.5752785983 54.2024339248 -43.2024339248
NZB/BlNJ m 22.0 24.5752785983 70.7024339248 -26.7024339248
NZO/HlLtJ f 34.3333333333 20.0656309508 74.0987041158 -5.4320374491
NZO/HlLtJ m 41.0 20.0656309508 80.7653707824 1.2346292176
PL/J f 21.0 24.5752785983 69.7024339248 -27.7024339248
PL/J m 112.0 20.0656309508 151.7653707824 72.2346292176
SM/J f 33.0 17.3773461464 67.4378212885 -1.4378212885
SM/J m 24.75 17.3773461464 59.1878212885 -9.6878212885


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
A/J both 13.6666666667 14.1885437141 41.7850300033 -14.45169667
AKR/J both 17.0 15.8632741232 48.4372859184 -14.4372859184
BALB/cByJ both 34.8333333333 14.1885437141 62.95169667 6.7149699967
BALB/cJ both 40.1666666667 14.1885437141 68.2850300033 12.04830333
BPL/1J both 71.5 14.1885437141 99.6183633366 43.3816366634
BXD2/TyJ both 72.8333333333 14.1885437141 100.95169667 44.7149699967
BXD31/TyJ both 39.8333333333 13.2721673489 66.135653804 13.5310128627
BXD38/TyJ both 51.3333333333 14.1885437141 79.45169667 23.2149699967
BXD42/TyJ both 52.6666666667 15.8632741232 84.1039525851 21.2293807483
BXD48a/RwwJ both 32.8333333333 14.1885437141 60.95169667 4.7149699967
BXD62/RwwJ both 20.5 17.3773461464 54.9378212885 -13.9378212885
BXD65/RwwJ both 67.0 14.1885437141 95.1183633366 38.8816366634
BXD84/RwwJ both 24.6666666667 14.1885437141 52.7850300033 -3.45169667
BXD98/RwwJ both 48.4166666667 15.8632741232 79.8539525851 16.9793807483
C3HeB/FeJ both 52.0833333333 15.8632741232 83.5206192517 20.6460474149
C57BL/10J both 38.8333333333 14.1885437141 66.95169667 10.7149699967
C57BL/6J both 26.6666666667 14.1885437141 54.7850300033 -1.45169667
C57BLKS/J both 28.25 17.3773461464 62.6878212885 -6.1878212885
C57BR/cdJ both 53.3333333333 14.1885437141 81.45169667 25.2149699967
C58/J both 55.0 14.1885437141 83.1183633366 26.8816366634
CBA/J both 15.5 14.1885437141 43.6183633366 -12.6183633366
KK/HlJ both 37.3333333333 14.1885437141 65.45169667 9.2149699967
LP/J both 14.0 17.3773461464 48.4378212885 -20.4378212885
MA/MyJ both 59.5 14.1885437141 87.6183633366 31.3816366634
MRL/MpJ both 24.6666666667 14.1885437141 52.7850300033 -3.45169667
NOD/ShiLtJ both 57.1666666667 14.1885437141 85.2850300033 29.04830333
NZB/BlNJ both 13.75 17.3773461464 48.1878212885 -20.6878212885
NZO/HlLtJ both 37.6666666667 14.1885437141 65.7850300033 9.54830333
PL/J both 66.5 15.8632741232 97.9372859184 35.0627140816
SM/J both 28.875 12.2876392991 53.2262169624 4.5237830376




  GWAS USING LINEAR MIXED MODELS