Project measure / variable:   Project1032   active_d5_cocaine

ID, description, units MPD:111480   active_d5_cocaine   number of active lever presses (during infusions and timeouts) (intravenous self administration), cocaine   [n]  day 5  
cocaine study
Data set, strains Project1032   HMDP   65 strains     sex: both     age: 9-15wks
Procedure operant conditioning chamber
Ontology mappings


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  STRAIN COMPARISON PLOT
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Project1032 - number of active lever presses (during infusions and timeouts) (intravenous self administration), cocaine day 5



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested60 strains61 strains
Mean of the strain means33.178   n 34.517   n
Median of the strain means26.25   n 32.0   n
SD of the strain means± 32.408 ± 23.238
Coefficient of variation (CV)0.9768 0.6732
Min–max range of strain means1.0   –   160.0   n 2.0   –   130.0   n
Mean sample size per strain2.1   mice 2.2   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 19.7591 19.7591 0.0198 0.8885
strain 30 70470.7842 2349.0261 2.35 0.0007
sex:strain 30 69030.1283 2301.0043 2.302 0.001
Residuals 108 107954.4167 999.5779


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
Select table page:
Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ m 52.0 19.799   2   14.0 0.3807 38.0, 66.0 0.75
129X1/SvJ f 16.0 0.0   1   0.0 0.0 16.0, 16.0 -0.53
A/J f 36.667 25.106   3 14.495 0.6847 9.0, 58.0 0.11
A/J m 3.5 2.1213   2   1.5 0.6061 2.0, 5.0 -1.33
AKR/J f 31.0 0.0   1   0.0 0.0 31.0, 31.0 -0.07
AKR/J m 25.0 21.213   2   15.0 0.8485 10.0, 40.0 -0.41
BALB/cByJ f 18.667 8.6217   3 4.9777 0.4619 11.0, 28.0 -0.45
BALB/cByJ m 36.667 23.671   3 13.667 0.6456 23.0, 64.0 0.09
BALB/cJ f 34.0 37.0   3 21.362 1.0882 1.0, 74.0 0.03
BALB/cJ m 31.0 40.706   3 23.502 1.3131 7.0, 78.0 -0.15
BPL/1J f 142.7 74.04   3 42.745 0.5189 70.0, 218.0 3.38
BPL/1J m 23.333 11.719   3 6.7659 0.5022 10.0, 32.0 -0.48
BTBR T+ Itpr3tf/J f 7.5 9.1924   2   6.5 1.2257 1.0, 14.0 -0.79
BTBR T+ Itpr3tf/J m 2.5 0.70711   2   0.5 0.2828 2.0, 3.0 -1.38
BXD100/RwwJ f 7.5 6.364   2   4.5 0.8485 3.0, 12.0 -0.79
BXD100/RwwJ m 25.0 0.0   1   0.0 0.0 25.0, 25.0 -0.41
BXD11/TyJ f 1.5 0.70711   2   0.5 0.4714 1.0, 2.0 -0.98
BXD11/TyJ m 36.0 0.0   1   0.0 0.0 36.0, 36.0 0.06
BXD15/TyJ f 59.33 12.055   3 6.9602 0.2032 48.0, 72.0 0.81
BXD15/TyJ m 41.0 0.0   1   0.0 0.0 41.0, 41.0 0.28
BXD1/TyJ f 35.0 0.0   1   0.0 0.0 35.0, 35.0 0.06
BXD1/TyJ m 49.0 29.866   3 17.243 0.6095 27.0, 83.0 0.62
BXD21/TyJ f 95.0 0.0   1   0.0 0.0 95.0, 95.0 1.91
BXD21/TyJ m 78.5 60.1   2   42.5 0.7657 36.0, 121.0 1.89
BXD2/TyJ f 28.667 4.9329   3 2.848 0.1721 23.0, 32.0 -0.14
BXD2/TyJ m 130.0 42.036   3 24.269 0.3234 96.0, 177.0 4.11
BXD31/TyJ f 49.0 6.0828   3 3.5119 0.1241 42.0, 53.0 0.49
BXD31/TyJ m 22.0 13.491   4 6.7454 0.6132 3.0, 33.0 -0.54
BXD32/TyJ f 12.0 0.0   1   0.0 0.0 12.0, 12.0 -0.65
BXD32/TyJ m 24.667 18.824   3 10.868 0.7631 3.0, 37.0 -0.42
BXD34/TyJ f 15.5 2.1213   2   1.5 0.1369 14.0, 17.0 -0.55
BXD38/TyJ f 51.5 20.506   2   14.5 0.3982 37.0, 66.0 0.57
BXD38/TyJ m 54.0 11.79   3 6.8069 0.2183 41.0, 64.0 0.84
BXD39/TyJ f 1.0 0.0   2   0.0 0.0 1.0, 1.0 -0.99
BXD39/TyJ m 12.667 14.572   3 8.413 1.1504 1.0, 29.0 -0.94
BXD40/TyJ f 2.0 1.4142   2   1.0 0.7071 1.0, 3.0 -0.96
BXD40/TyJ m 39.0 52.33   2   37.0 1.3417 2.0, 76.0 0.19
BXD42/TyJ f 46.5 37.477   2   26.5 0.8059 20.0, 73.0 0.41
BXD42/TyJ m 54.33 10.017   3 5.7831 0.1844 44.0, 64.0 0.85
BXD48a/RwwJ f 17.333 22.502   3 12.991 1.2982 1.0, 43.0 -0.49
BXD48a/RwwJ m 41.333 8.5049   3 4.9103 0.2058 33.0, 50.0 0.29
BXD50/RwwJ f 1.0 0.0   1   0.0 0.0 1.0, 1.0 -0.99
BXD50/RwwJ m 20.0 4.2426   2   3.0 0.2121 17.0, 23.0 -0.62
BXD55/RwwJ f 66.5 28.991   2   20.5 0.436 46.0, 87.0 1.03
BXD55/RwwJ m 36.0 0.0   1   0.0 0.0 36.0, 36.0 0.06
BXD56/RwwJ m 3.0 0.0   1   0.0 0.0 3.0, 3.0 -1.36
BXD60/RwwJ f 38.0 0.0   1   0.0 0.0 38.0, 38.0 0.15
BXD60/RwwJ m 50.5 27.577   2   19.5 0.5461 31.0, 70.0 0.69
BXD61/RwwJ f 13.333 8.9629   3 5.1747 0.6722 3.0, 19.0 -0.61
BXD61/RwwJ m 33.0 0.0   1   0.0 0.0 33.0, 33.0 -0.07
BXD62/RwwJ f 3.5 3.5355   2   2.5 1.0102 1.0, 6.0 -0.92
BXD62/RwwJ m 25.0 29.698   2   21.0 1.1879 4.0, 46.0 -0.41
BXD63/RwwJ m 4.0 0.0   1   0.0 0.0 4.0, 4.0 -1.31
BXD65/RwwJ f 57.33 21.572   3 12.454 0.3762 42.0, 82.0 0.75
BXD65/RwwJ m 27.667 8.0829   3 4.6667 0.2922 19.0, 35.0 -0.29
BXD68/RwwJ m 31.333 28.29   3 16.333 0.9029 1.0, 57.0 -0.14
BXD69/RwwJ f 44.0 7.0711   2   5.0 0.1607 39.0, 49.0 0.33
BXD70/RwwJ f 2.0 0.0   1   0.0 0.0 2.0, 2.0 -0.96
BXD70/RwwJ m 66.0 0.0   1   0.0 0.0 66.0, 66.0 1.35
BXD71/RwwJ f 40.0 0.0   1   0.0 0.0 40.0, 40.0 0.21
BXD71/RwwJ m 35.0 0.0   1   0.0 0.0 35.0, 35.0 0.02
BXD73a/RwwJ f 38.0 9.8995   2   7.0 0.2605 31.0, 45.0 0.15
BXD73a/RwwJ m 37.0 0.0   1   0.0 0.0 37.0, 37.0 0.11
BXD75/RwwJ f 160.0 0.0   1   0.0 0.0 160.0, 160.0 3.91
BXD75/RwwJ m 45.5 21.92   2   15.5 0.4818 30.0, 61.0 0.47
BXD77/RwwJ f 15.0 23.388   3 13.503 1.5592 1.0, 42.0 -0.56
BXD77/RwwJ m 38.333 31.47   3 18.169 0.8209 2.0, 57.0 0.16
BXD84/RwwJ f 23.667 23.029   3 13.296 0.9731 4.0, 49.0 -0.29
BXD84/RwwJ m 18.0 15.524   3 8.9629 0.8625 3.0, 34.0 -0.71
BXD90/RwwJ m 57.5 40.305   2   28.5 0.701 29.0, 86.0 0.99
BXD98/RwwJ f 48.5 3.5355   2   2.5 0.0729 46.0, 51.0 0.47
BXD98/RwwJ m 39.333 8.5049   3 4.9103 0.2162 31.0, 48.0 0.21
BXD99/RwwJ f 25.0 0.0   1   0.0 0.0 25.0, 25.0 -0.25
BXD99/RwwJ m 32.0 0.0   1   0.0 0.0 32.0, 32.0 -0.11
C3HeB/FeJ f 16.5 2.1213   2   1.5 0.1286 15.0, 18.0 -0.51
C3HeB/FeJ m 28.5 12.021   2   8.5 0.4218 20.0, 37.0 -0.26
C3H/HeJ f 1.6667 0.57735   3 0.33333 0.3464 1.0, 2.0 -0.97
C3H/HeJ m 8.0 7.2111   3 4.1633 0.9014 2.0, 16.0 -1.14
C57BL/10J f 29.667 23.798   3 13.74 0.8022 4.0, 51.0 -0.11
C57BL/10J m 16.5 12.021   2   8.5 0.7285 8.0, 25.0 -0.78
C57BL/6J f 5.0 0.0   1   0.0 0.0 5.0, 5.0 -0.87
C57BL/6J m 42.0 8.1854   3 4.7258 0.1949 33.0, 49.0 0.32
C57BLKS/J f 55.5 16.263   2   11.5 0.293 44.0, 67.0 0.69
C57BLKS/J m 44.0 0.0   1   0.0 0.0 44.0, 44.0 0.41
C57BR/cdJ f 63.67 5.8595   3 3.383 0.092 57.0, 68.0 0.94
C57BR/cdJ m 31.333 7.0946   3 4.0961 0.2264 25.0, 39.0 -0.14
C57L/J f 61.0 0.0   1   0.0 0.0 61.0, 61.0 0.86
C57L/J m 54.0 7.0   3 4.0415 0.1296 49.0, 62.0 0.84
C58/J f 92.0 68.15   3 39.345 0.7407 44.0, 170.0 1.82
C58/J m 47.0 18.028   3 10.408 0.3836 32.0, 67.0 0.54
CBA/J f 30.5 37.477   2   26.5 1.2287 4.0, 57.0 -0.08
CBA/J m 13.667 10.693   3 6.1734 0.7824 7.0, 26.0 -0.9
DBA/1J f 9.0 7.0   3 4.0415 0.7778 1.0, 14.0 -0.75
DBA/1J m 20.0 0.0   1   0.0 0.0 20.0, 20.0 -0.62
DBA/2J f 1.0 0.0   1   0.0 0.0 1.0, 1.0 -0.99
FVB/NJ f 8.6667 9.2916   3 5.3645 1.0721 1.0, 19.0 -0.76
FVB/NJ m 15.0 0.0   1   0.0 0.0 15.0, 15.0 -0.84
I/LnJ f 18.5 10.607   2   7.5 0.5733 11.0, 26.0 -0.45
I/LnJ m 11.0 0.0   1   0.0 0.0 11.0, 11.0 -1.01
KK/HlJ f 9.6667 8.0829   3 4.6667 0.8362 1.0, 17.0 -0.73
KK/HlJ m 63.0 24.269   3 14.012 0.3852 43.0, 90.0 1.23
LP/J f 9.0 0.0   1   0.0 0.0 9.0, 9.0 -0.75
LP/J m 27.5 14.849   2   10.5 0.54 17.0, 38.0 -0.3
MA/MyJ f 51.0 19.079   3 11.015 0.3741 33.0, 71.0 0.55
MA/MyJ m 40.333 8.0829   3 4.6667 0.2004 33.0, 49.0 0.25
MRL/MpJ f 18.0 27.731   3 16.01 1.5406 1.0, 50.0 -0.47
MRL/MpJ m 30.5 41.719   2   29.5 1.3678 1.0, 60.0 -0.17
NOD/ShiLtJ f 64.0 11.0   3 6.3509 0.1719 53.0, 75.0 0.95
NOD/ShiLtJ m 45.667 17.502   3 10.105 0.3833 28.0, 63.0 0.48
NZB/BlNJ f 1.0 0.0   1   0.0 0.0 1.0, 1.0 -0.99
NZB/BlNJ m 17.333 13.577   3 7.8387 0.7833 3.0, 30.0 -0.74
NZO/HlLtJ f 31.667 15.044   3 8.6859 0.4751 22.0, 49.0 -0.05
NZO/HlLtJ m 32.0 18.248   3 10.536 0.5703 20.0, 53.0 -0.11
NZW/LacJ f 76.0 70.71   2   50.0 0.9304 26.0, 126.0 1.32
NZW/LacJ m 4.0 4.2426   2   3.0 1.0607 1.0, 7.0 -1.31
PL/J f 26.0 35.355   2   25.0 1.3598 1.0, 51.0 -0.22
PL/J m 109.3 146.6   3 84.66 1.3413 5.0, 277.0 3.22
SJL/J f 1.0 0.0   1   0.0 0.0 1.0, 1.0 -0.99
SJL/J m 2.0 0.0   1   0.0 0.0 2.0, 2.0 -1.4
SM/J f 26.5 9.434   4 4.717 0.356 13.0, 35.0 -0.21
SM/J m 22.25 9.1788   4 4.5894 0.4125 17.0, 36.0 -0.53


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
A/J f 36.6666666667 18.2535652417 72.8483996646 0.4849336687
A/J m 3.5 22.3559604144 47.8133919273 -40.8133919273
BALB/cByJ f 18.6666666667 18.2535652417 54.8483996646 -17.5150663313
BALB/cByJ m 36.6666666667 18.2535652417 72.8483996646 0.4849336687
BALB/cJ f 34.0 18.2535652417 70.1817329979 -2.1817329979
BALB/cJ m 31.0 18.2535652417 67.1817329979 -5.1817329979
BPL/1J f 142.6666666667 18.2535652417 178.8483996646 106.4849336687
BPL/1J m 23.3333333333 18.2535652417 59.5150663313 -12.8483996646
BTBR T+ Itpr3tf/J f 7.5 22.3559604144 51.8133919273 -36.8133919273
BTBR T+ Itpr3tf/J m 2.5 22.3559604144 46.8133919273 -41.8133919273
BXD2/TyJ f 28.6666666667 18.2535652417 64.8483996646 -7.5150663313
BXD2/TyJ m 130.0 18.2535652417 166.1817329979 93.8182670021
BXD31/TyJ f 49.0 18.2535652417 85.1817329979 12.8182670021
BXD31/TyJ m 22.0 15.8080512089 53.3342999291 -9.3342999291
BXD38/TyJ f 51.5 22.3559604144 95.8133919273 7.1866080727
BXD38/TyJ m 54.0 18.2535652417 90.1817329979 17.8182670021
BXD39/TyJ f 1.0 22.3559604144 45.3133919273 -43.3133919273
BXD39/TyJ m 12.6666666667 18.2535652417 48.8483996646 -23.5150663313
BXD40/TyJ f 2.0 22.3559604144 46.3133919273 -42.3133919273
BXD40/TyJ m 39.0 22.3559604144 83.3133919273 -5.3133919273
BXD42/TyJ f 46.5 22.3559604144 90.8133919273 2.1866080727
BXD42/TyJ m 54.3333333333 18.2535652417 90.5150663313 18.1516003354
BXD48a/RwwJ f 17.3333333333 18.2535652417 53.5150663313 -18.8483996646
BXD48a/RwwJ m 41.3333333333 18.2535652417 77.5150663313 5.1516003354
BXD62/RwwJ f 3.5 22.3559604144 47.8133919273 -40.8133919273
BXD62/RwwJ m 25.0 22.3559604144 69.3133919273 -19.3133919273
BXD65/RwwJ f 57.3333333333 18.2535652417 93.5150663313 21.1516003354
BXD65/RwwJ m 27.6666666667 18.2535652417 63.8483996646 -8.5150663313
BXD77/RwwJ f 15.0 18.2535652417 51.1817329979 -21.1817329979
BXD77/RwwJ m 38.3333333333 18.2535652417 74.5150663313 2.1516003354
BXD84/RwwJ f 23.6666666667 18.2535652417 59.8483996646 -12.5150663313
BXD84/RwwJ m 18.0 18.2535652417 54.1817329979 -18.1817329979
BXD98/RwwJ f 48.5 22.3559604144 92.8133919273 4.1866080727
BXD98/RwwJ m 39.3333333333 18.2535652417 75.5150663313 3.1516003354
C3HeB/FeJ f 16.5 22.3559604144 60.8133919273 -27.8133919273
C3HeB/FeJ m 28.5 22.3559604144 72.8133919273 -15.8133919273
C3H/HeJ f 1.6666666667 18.2535652417 37.8483996646 -34.5150663313
C3H/HeJ m 8.0 18.2535652417 44.1817329979 -28.1817329979
C57BL/10J f 29.6666666667 18.2535652417 65.8483996646 -6.5150663313
C57BL/10J m 16.5 22.3559604144 60.8133919273 -27.8133919273
C57BR/cdJ f 63.6666666667 18.2535652417 99.8483996646 27.4849336687
C57BR/cdJ m 31.3333333333 18.2535652417 67.5150663313 -4.8483996646
C58/J f 92.0 18.2535652417 128.1817329979 55.8182670021
C58/J m 47.0 18.2535652417 83.1817329979 10.8182670021
CBA/J f 30.5 22.3559604144 74.8133919273 -13.8133919273
CBA/J m 13.6666666667 18.2535652417 49.8483996646 -22.5150663313
KK/HlJ f 9.6666666667 18.2535652417 45.8483996646 -26.5150663313
KK/HlJ m 63.0 18.2535652417 99.1817329979 26.8182670021
MA/MyJ f 51.0 18.2535652417 87.1817329979 14.8182670021
MA/MyJ m 40.3333333333 18.2535652417 76.5150663313 4.1516003354
MRL/MpJ f 18.0 18.2535652417 54.1817329979 -18.1817329979
MRL/MpJ m 30.5 22.3559604144 74.8133919273 -13.8133919273
NOD/ShiLtJ f 64.0 18.2535652417 100.1817329979 27.8182670021
NOD/ShiLtJ m 45.6666666667 18.2535652417 81.8483996646 9.4849336687
NZO/HlLtJ f 31.6666666667 18.2535652417 67.8483996646 -4.5150663313
NZO/HlLtJ m 32.0 18.2535652417 68.1817329979 -4.1817329979
NZW/LacJ f 76.0 22.3559604144 120.3133919273 31.6866080727
NZW/LacJ m 4.0 22.3559604144 48.3133919273 -40.3133919273
PL/J f 26.0 22.3559604144 70.3133919273 -18.3133919273
PL/J m 109.3333333333 18.2535652417 145.5150663313 73.1516003354
SM/J f 26.5 15.8080512089 57.8342999291 -4.8342999291
SM/J m 22.25 15.8080512089 53.5842999291 -9.0842999291


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
A/J both 20.0833333333 14.4307103956 48.6875048247 -8.520838158
BALB/cByJ both 27.6666666667 12.9072197632 53.2510154246 2.0823179088
BALB/cJ both 32.5 12.9072197632 58.0843487579 6.9156512421
BPL/1J both 83.0 12.9072197632 108.5843487579 57.4156512421
BTBR T+ Itpr3tf/J both 5.0 15.8080512089 36.3342999291 -26.3342999291
BXD2/TyJ both 79.3333333333 12.9072197632 104.9176820912 53.7489845754
BXD31/TyJ both 35.5 12.0735985425 59.431966879 11.568033121
BXD38/TyJ both 52.75 14.4307103956 81.3541714914 24.1458285086
BXD39/TyJ both 6.8333333333 14.4307103956 35.4375048247 -21.770838158
BXD40/TyJ both 20.5 15.8080512089 51.8342999291 -10.8342999291
BXD42/TyJ both 50.4166666667 14.4307103956 79.020838158 21.8124951753
BXD48a/RwwJ both 29.3333333333 12.9072197632 54.9176820912 3.7489845754
BXD62/RwwJ both 14.25 15.8080512089 45.5842999291 -17.0842999291
BXD65/RwwJ both 42.5 12.9072197632 68.0843487579 16.9156512421
BXD77/RwwJ both 26.6666666667 12.9072197632 52.2510154246 1.0823179088
BXD84/RwwJ both 20.8333333333 12.9072197632 46.4176820912 -4.7510154246
BXD98/RwwJ both 43.9166666667 14.4307103956 72.520838158 15.3124951753
C3HeB/FeJ both 22.5 15.8080512089 53.8342999291 -8.8342999291
C3H/HeJ both 4.8333333333 12.9072197632 30.4176820912 -20.7510154246
C57BL/10J both 23.0833333333 14.4307103956 51.6875048247 -5.520838158
C57BR/cdJ both 47.5 12.9072197632 73.0843487579 21.9156512421
C58/J both 69.5 12.9072197632 95.0843487579 43.9156512421
CBA/J both 22.0833333333 14.4307103956 50.6875048247 -6.520838158
KK/HlJ both 36.3333333333 12.9072197632 61.9176820912 10.7489845754
MA/MyJ both 45.6666666667 12.9072197632 71.2510154246 20.0823179088
MRL/MpJ both 24.25 14.4307103956 52.8541714914 -4.3541714914
NOD/ShiLtJ both 54.8333333333 12.9072197632 80.4176820912 29.2489845754
NZO/HlLtJ both 31.8333333333 12.9072197632 57.4176820912 6.2489845754
NZW/LacJ both 40.0 15.8080512089 71.3342999291 8.6657000709
PL/J both 67.6666666667 14.4307103956 96.270838158 39.0624951753
SM/J both 24.375 11.1779802072 46.5316959636 2.2183040364




  GWAS USING LINEAR MIXED MODELS