Project measure / variable:   Project1032   active_pct_d8_10_cocaine

ID, description, units MPD:111465   active_pct_d8_10_cocaine   percentage of lever presses that are active (intravenous self administration) combined, cocaine   [%]  days 8-10  
cocaine study
Data set, strains Project1032   HMDP   66 strains     sex: both     age: 9-15wks
Procedure operant conditioning chamber
Ontology mappings


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  STRAIN COMPARISON PLOT
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Project1032 - percentage of lever presses that are active (intravenous self administration) combined, cocaine days 8-10



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested64 strains64 strains
Mean of the strain means79.75   % 78.67   %
Median of the strain means83.05   % 82.37   %
SD of the strain means± 15.429 ± 19.172
Coefficient of variation (CV)0.1935 0.2437
Min–max range of strain means33.3   –   100.0   % 14.1   –   100.0   %
Mean sample size per strain2.2   mice 2.4   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 68.8852 68.8852 0.1474 0.7016
strain 36 27739.9157 770.5532 1.649 0.0219
sex:strain 36 21255.1912 590.422 1.2635 0.1714
Residuals 134 62615.5675 467.2804


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
Select table page:
Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ f 100.0 0.0   1   0.0 0.0 100.0, 100.0 1.31
129S1/SvImJ m 93.1 8.7681   2   6.2 0.0942 86.9, 99.3 0.75
129X1/SvJ f 100.0 0.0   1   0.0 0.0 100.0, 100.0 1.31
129X1/SvJ m 100.0 0.0   2   0.0 0.0 100.0, 100.0 1.11
A/J f 79.2 15.649   3 9.0349 0.1976 67.2, 96.9 -0.04
A/J m 49.3 35.764   3 20.649 0.7254 12.0, 83.3 -1.53
AKR/J f 83.6 17.253   2   12.2 0.2064 71.4, 95.8 0.25
AKR/J m 96.1 1.6971   2   1.2 0.0177 94.9, 97.3 0.91
BALB/cByJ f 88.37 6.7855   3 3.9176 0.0768 84.3, 96.2 0.56
BALB/cByJ m 81.73 18.877   3 10.899 0.231 62.3, 100.0 0.16
BALB/cJ f 80.85 20.011   2   14.15 0.2475 66.7, 95.0 0.07
BALB/cJ m 61.7 11.317   3 6.5338 0.1834 49.1, 71.0 -0.89
BPL/1J f 63.37 31.988   3 18.469 0.5048 37.4, 99.1 -1.06
BPL/1J m 65.73 25.134   3 14.511 0.3824 49.7, 94.7 -0.67
BTBR T+ Itpr3tf/J f 77.5 24.749   2   17.5 0.3193 60.0, 95.0 -0.15
BTBR T+ Itpr3tf/J m 82.23 16.762   3 9.6775 0.2038 66.7, 100.0 0.19
BXD100/RwwJ f 89.1 9.4752   2   6.7 0.1063 82.4, 95.8 0.61
BXD100/RwwJ m 90.1 0.0   1   0.0 0.0 90.1, 90.1 0.6
BXD11/TyJ f 56.93 27.757   3 16.026 0.4875 33.3, 87.5 -1.48
BXD11/TyJ m 14.1 0.0   1   0.0 0.0 14.1, 14.1 -3.37
BXD15/TyJ f 91.03 14.063   3 8.1192 0.1545 74.8, 99.5 0.73
BXD15/TyJ m 99.5 0.0   1   0.0 0.0 99.5, 99.5 1.09
BXD1/TyJ f 92.85 10.112   2   7.15 0.1089 85.7, 100.0 0.85
BXD1/TyJ m 95.83 5.0619   3 2.9225 0.0528 90.2, 100.0 0.89
BXD21/TyJ f 85.5 0.0   1   0.0 0.0 85.5, 85.5 0.37
BXD21/TyJ m 84.6 5.6569   2   4.0 0.0669 80.6, 88.6 0.31
BXD28/TyJ f 100.0 0.0   1   0.0 0.0 100.0, 100.0 1.31
BXD28/TyJ m 100.0 0.0   1   0.0 0.0 100.0, 100.0 1.11
BXD2/TyJ f 45.067 10.409   3 6.0095 0.231 33.9, 54.5 -2.25
BXD2/TyJ m 85.4 21.509   3 12.418 0.2519 60.7, 100.0 0.35
BXD31/TyJ f 94.3 8.4077   3 4.8542 0.0892 84.6, 99.5 0.94
BXD31/TyJ m 79.72 13.859   4 6.9295 0.1738 65.1, 97.5 0.05
BXD32/TyJ f 87.2 8.7681   2   6.2 0.1006 81.0, 93.4 0.48
BXD32/TyJ m 85.85 3.7477   2   2.65 0.0437 83.2, 88.5 0.37
BXD34/TyJ f 83.6 0.98995   2   0.7 0.0118 82.9, 84.3 0.25
BXD34/TyJ m 84.0 0.0   1   0.0 0.0 84.0, 84.0 0.28
BXD38/TyJ f 86.27 5.8449   3 3.3746 0.0678 82.5, 93.0 0.42
BXD38/TyJ m 71.1 42.18   3 24.353 0.5933 22.4, 96.1 -0.39
BXD39/TyJ f 63.6 0.0   1   0.0 0.0 63.6, 63.6 -1.05
BXD39/TyJ m 91.17 6.8017   3 3.927 0.0746 84.9, 98.4 0.65
BXD40/TyJ f 33.3 0.0   1   0.0 0.0 33.3, 33.3 -3.01
BXD40/TyJ m 82.5 28.174   3 16.266 0.3415 50.0, 100.0 0.2
BXD42/TyJ f 69.3 40.305   2   28.5 0.5816 40.8, 97.8 -0.68
BXD42/TyJ m 96.23 5.4372   3 3.1392 0.0565 90.0, 100.0 0.92
BXD48a/RwwJ f 97.55 1.7678   2   1.25 0.0181 96.3, 98.8 1.15
BXD48a/RwwJ m 72.5 26.845   3 15.499 0.3703 43.4, 96.3 -0.32
BXD50/RwwJ f 74.2 0.0   1   0.0 0.0 74.2, 74.2 -0.36
BXD50/RwwJ m 65.9 31.82   2   22.5 0.4828 43.4, 88.4 -0.67
BXD55/RwwJ f 92.25 9.1217   2   6.45 0.0989 85.8, 98.7 0.81
BXD55/RwwJ m 40.6 0.0   1   0.0 0.0 40.6, 40.6 -1.99
BXD56/RwwJ m 66.7 0.0   1   0.0 0.0 66.7, 66.7 -0.62
BXD60/RwwJ f 97.0 0.0   1   0.0 0.0 97.0, 97.0 1.12
BXD60/RwwJ m 93.4 7.7782   2   5.5 0.0833 87.9, 98.9 0.77
BXD61/RwwJ f 77.37 31.493   3 18.183 0.4071 41.4, 100.0 -0.15
BXD61/RwwJ m 100.0 0.0   1   0.0 0.0 100.0, 100.0 1.11
BXD62/RwwJ f 82.5 15.795   3 9.1194 0.1915 65.0, 95.7 0.18
BXD62/RwwJ m 90.65 13.223   2   9.35 0.1459 81.3, 100.0 0.62
BXD63/RwwJ f 66.7 0.0   1   0.0 0.0 66.7, 66.7 -0.85
BXD63/RwwJ m 71.4 0.0   1   0.0 0.0 71.4, 71.4 -0.38
BXD65/RwwJ f 85.17 13.117   3 7.5728 0.154 75.1, 100.0 0.35
BXD65/RwwJ m 95.2 4.2   3 2.4249 0.0441 92.2, 100.0 0.86
BXD68/RwwJ f 66.1 0.0   1   0.0 0.0 66.1, 66.1 -0.88
BXD68/RwwJ m 90.83 14.514   3 8.3794 0.1598 74.1, 100.0 0.63
BXD69/RwwJ f 65.0 35.921   2   25.4 0.5526 39.6, 90.4 -0.96
BXD70/RwwJ f 70.4 0.0   1   0.0 0.0 70.4, 70.4 -0.61
BXD70/RwwJ m 61.1 55.01   2   38.9 0.9004 22.2, 100.0 -0.92
BXD71/RwwJ f 77.3 0.0   1   0.0 0.0 77.3, 77.3 -0.16
BXD71/RwwJ m 61.1 15.415   2   10.9 0.2523 50.2, 72.0 -0.92
BXD73a/RwwJ f 88.9 14.001   2   9.9 0.1575 79.0, 98.8 0.59
BXD73a/RwwJ m 18.4 0.0   1   0.0 0.0 18.4, 18.4 -3.14
BXD75/RwwJ f 86.4 0.0   1   0.0 0.0 86.4, 86.4 0.43
BXD75/RwwJ m 75.75 7.7075   2   5.45 0.1017 70.3, 81.2 -0.15
BXD77/RwwJ f 61.17 26.654   3 15.389 0.4358 40.0, 91.1 -1.2
BXD77/RwwJ m 89.53 8.1868   3 4.7266 0.0914 80.2, 95.5 0.57
BXD84/RwwJ f 74.87 24.784   3 14.309 0.331 47.5, 95.8 -0.32
BXD84/RwwJ m 81.57 12.25   3 7.0726 0.1502 74.0, 95.7 0.15
BXD90/RwwJ m 91.0 1.8385   2   1.3 0.0202 89.7, 92.3 0.64
BXD98/RwwJ f 95.35 6.5761   2   4.65 0.069 90.7, 100.0 1.01
BXD98/RwwJ m 97.13 0.15275   3 0.08819 0.0016 97.0, 97.3 0.96
BXD99/RwwJ f 76.6 0.0   1   0.0 0.0 76.6, 76.6 -0.2
BXD99/RwwJ m 85.7 0.0   1   0.0 0.0 85.7, 85.7 0.37
C3HeB/FeJ f 58.13 10.947   3 6.3204 0.1883 45.8, 66.7 -1.4
C3HeB/FeJ m 93.3 4.9497   2   3.5 0.0531 89.8, 96.8 0.76
C3H/HeJ f 59.97 29.826   3 17.22 0.4974 36.4, 93.5 -1.28
C3H/HeJ m 68.07 28.707   3 16.574 0.4217 44.4, 100.0 -0.55
C57BL/10J f 88.1 5.2202   3 3.0139 0.0593 84.6, 94.1 0.54
C57BL/10J m 94.17 4.3016   3 2.4835 0.0457 90.3, 98.8 0.81
C57BL/6J f 91.6 11.879   2   8.4 0.1297 83.2, 100.0 0.77
C57BL/6J m 89.63 7.8258   3 4.5182 0.0873 80.8, 95.7 0.57
C57BLKS/J f 55.83 41.745   3 24.102 0.7477 10.3, 92.3 -1.55
C57BLKS/J m 77.5 38.28   3 22.101 0.4939 33.3, 100.0 -0.06
C57BR/cdJ f 88.27 14.091   3 8.1352 0.1596 72.0, 96.7 0.55
C57BR/cdJ m 93.7 7.3668   3 4.2532 0.0786 85.6, 100.0 0.78
C57L/J f 98.2 0.0   1   0.0 0.0 98.2, 98.2 1.2
C57L/J m 79.13 12.431   3 7.1769 0.1571 68.5, 92.8 0.02
C58/J f 94.33 4.236   3 2.4456 0.0449 91.0, 99.1 0.95
C58/J m 89.7 13.238   3 7.6429 0.1476 74.5, 98.7 0.58
CBA/J f 72.03 26.852   3 15.503 0.3728 42.1, 94.0 -0.5
CBA/J m 95.47 3.6556   3 2.1106 0.0383 91.7, 99.0 0.88
DBA/1J f 84.53 11.418   3 6.592 0.1351 71.4, 92.1 0.31
DBA/1J m 93.9 0.0   1   0.0 0.0 93.9, 93.9 0.79
DBA/2J f 66.7 0.0   1   0.0 0.0 66.7, 66.7 -0.85
DBA/2J m 50.0 0.0   1   0.0 0.0 50.0, 50.0 -1.5
FVB/NJ f 79.3 29.274   2   20.7 0.3692 58.6, 100.0 -0.03
FVB/NJ m 80.1 18.509   3 10.686 0.2311 63.4, 100.0 0.07
I/LnJ f 97.7 0.70711   2   0.5 0.0072 97.2, 98.2 1.16
I/LnJ m 74.0 0.0   1   0.0 0.0 74.0, 74.0 -0.24
KK/HlJ f 72.9 34.887   3 20.142 0.4786 33.3, 99.1 -0.44
KK/HlJ m 53.7 23.693   3 13.679 0.4412 26.6, 70.5 -1.3
LP/J f 98.1 2.687   2   1.9 0.0274 96.2, 100.0 1.19
LP/J m 97.65 1.0607   2   0.75 0.0109 96.9, 98.4 0.99
MA/MyJ f 64.5 38.761   3 22.379 0.6009 21.6, 97.0 -0.99
MA/MyJ m 99.3 0.88882   3 0.51316 0.009 98.3, 100.0 1.08
MRL/MpJ f 75.37 23.994   3 13.853 0.3184 50.0, 97.7 -0.28
MRL/MpJ m 79.0 32.058   3 18.509 0.4058 42.1, 100.0 0.02
NOD/ShiLtJ f 39.2 30.553   3 17.64 0.7794 14.6, 73.4 -2.63
NOD/ShiLtJ m 59.7 33.472   3 19.325 0.5607 38.7, 98.3 -0.99
NZB/BlNJ f 98.7 2.2517   3 1.3 0.0228 96.1, 100.0 1.23
NZB/BlNJ m 79.5 24.287   3 14.022 0.3055 52.4, 99.3 0.04
NZO/HlLtJ f 95.2 6.4094   3 3.7005 0.0673 87.8, 99.0 1.0
NZO/HlLtJ m 69.53 45.843   3 26.468 0.6593 16.6, 96.4 -0.48
NZW/LacJ f 94.57 7.7436   3 4.4708 0.0819 85.7, 100.0 0.96
NZW/LacJ m 78.97 32.363   3 18.685 0.4098 41.7, 100.0 0.02
PL/J f 92.15 9.5459   2   6.75 0.1036 85.4, 98.9 0.8
PL/J m 30.333 17.126   3 9.8878 0.5646 10.7, 42.2 -2.52
SJL/J f 72.45 14.071   2   9.95 0.1942 62.5, 82.4 -0.47
SM/J f 80.25 17.432   4 8.7161 0.2172 58.7, 98.9 0.03
SM/J m 70.15 30.284   4 15.142 0.4317 32.9, 96.1 -0.44


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
A/J f 79.2 12.4803893433 103.884035514 54.515964486
A/J m 49.3 12.4803893433 73.984035514 24.615964486
AKR/J f 83.6 15.2852928411 113.8316459011 53.3683540989
AKR/J m 96.1 15.2852928411 126.3316459011 65.8683540989
BALB/cByJ f 88.3666666667 12.4803893433 113.0507021807 63.6826311526
BALB/cByJ m 81.7333333333 12.4803893433 106.4173688474 57.0492978193
BALB/cJ f 80.85 15.2852928411 111.0816459011 50.6183540989
BALB/cJ m 61.7 12.4803893433 86.384035514 37.015964486
BPL/1J f 63.3666666667 12.4803893433 88.0507021807 38.6826311526
BPL/1J m 65.7333333333 12.4803893433 90.4173688474 41.0492978193
BTBR T+ Itpr3tf/J f 77.5 15.2852928411 107.7316459011 47.2683540989
BTBR T+ Itpr3tf/J m 82.2333333333 12.4803893433 106.9173688474 57.5492978193
BXD1/TyJ f 92.85 15.2852928411 123.0816459011 62.6183540989
BXD1/TyJ m 95.8333333333 12.4803893433 120.5173688474 71.1492978193
BXD2/TyJ f 45.0666666667 12.4803893433 69.7507021807 20.3826311526
BXD2/TyJ m 85.4 12.4803893433 110.084035514 60.715964486
BXD31/TyJ f 94.3 12.4803893433 118.984035514 69.615964486
BXD31/TyJ m 79.725 10.8083342204 101.1020018231 58.3479981769
BXD32/TyJ f 87.2 15.2852928411 117.4316459011 56.9683540989
BXD32/TyJ m 85.85 15.2852928411 116.0816459011 55.6183540989
BXD38/TyJ f 86.2666666667 12.4803893433 110.9507021807 61.5826311526
BXD38/TyJ m 71.1 12.4803893433 95.784035514 46.415964486
BXD42/TyJ f 69.3 15.2852928411 99.5316459011 39.0683540989
BXD42/TyJ m 96.2333333333 12.4803893433 120.9173688474 71.5492978193
BXD48a/RwwJ f 97.55 15.2852928411 127.7816459011 67.3183540989
BXD48a/RwwJ m 72.5 12.4803893433 97.184035514 47.815964486
BXD62/RwwJ f 82.5 12.4803893433 107.184035514 57.815964486
BXD62/RwwJ m 90.65 15.2852928411 120.8816459011 60.4183540989
BXD65/RwwJ f 85.1666666667 12.4803893433 109.8507021807 60.4826311526
BXD65/RwwJ m 95.2 12.4803893433 119.884035514 70.515964486
BXD77/RwwJ f 61.1666666667 12.4803893433 85.8507021807 36.4826311526
BXD77/RwwJ m 89.5333333333 12.4803893433 114.2173688474 64.8492978193
BXD84/RwwJ f 74.8666666667 12.4803893433 99.5507021807 50.1826311526
BXD84/RwwJ m 81.5666666667 12.4803893433 106.2507021807 56.8826311526
BXD98/RwwJ f 95.35 15.2852928411 125.5816459011 65.1183540989
BXD98/RwwJ m 97.1333333333 12.4803893433 121.8173688474 72.4492978193
C3HeB/FeJ f 58.1333333333 12.4803893433 82.8173688474 33.4492978193
C3HeB/FeJ m 93.3 15.2852928411 123.5316459011 63.0683540989
C3H/HeJ f 59.9666666667 12.4803893433 84.6507021807 35.2826311526
C3H/HeJ m 68.0666666667 12.4803893433 92.7507021807 43.3826311526
C57BL/10J f 88.1 12.4803893433 112.784035514 63.415964486
C57BL/10J m 94.1666666667 12.4803893433 118.8507021807 69.4826311526
C57BL/6J f 91.6 15.2852928411 121.8316459011 61.3683540989
C57BL/6J m 89.6333333333 12.4803893433 114.3173688474 64.9492978193
C57BLKS/J f 55.8333333333 12.4803893433 80.5173688474 31.1492978193
C57BLKS/J m 77.5 12.4803893433 102.184035514 52.815964486
C57BR/cdJ f 88.2666666667 12.4803893433 112.9507021807 63.5826311526
C57BR/cdJ m 93.7 12.4803893433 118.384035514 69.015964486
C58/J f 94.3333333333 12.4803893433 119.0173688474 69.6492978193
C58/J m 89.7 12.4803893433 114.384035514 65.015964486
CBA/J f 72.0333333333 12.4803893433 96.7173688474 47.3492978193
CBA/J m 95.4666666667 12.4803893433 120.1507021807 70.7826311526
FVB/NJ f 79.3 15.2852928411 109.5316459011 49.0683540989
FVB/NJ m 80.1 12.4803893433 104.784035514 55.415964486
KK/HlJ f 72.9 12.4803893433 97.584035514 48.215964486
KK/HlJ m 53.7 12.4803893433 78.384035514 29.015964486
LP/J f 98.1 15.2852928411 128.3316459011 67.8683540989
LP/J m 97.65 15.2852928411 127.8816459011 67.4183540989
MA/MyJ f 64.5 12.4803893433 89.184035514 39.815964486
MA/MyJ m 99.3 12.4803893433 123.984035514 74.615964486
MRL/MpJ f 75.3666666667 12.4803893433 100.0507021807 50.6826311526
MRL/MpJ m 79.0 12.4803893433 103.684035514 54.315964486
NOD/ShiLtJ f 39.2 12.4803893433 63.884035514 14.515964486
NOD/ShiLtJ m 59.7 12.4803893433 84.384035514 35.015964486
NZB/BlNJ f 98.7 12.4803893433 123.384035514 74.015964486
NZB/BlNJ m 79.5 12.4803893433 104.184035514 54.815964486
NZO/HlLtJ f 95.2 12.4803893433 119.884035514 70.515964486
NZO/HlLtJ m 69.5333333333 12.4803893433 94.2173688474 44.8492978193
NZW/LacJ f 94.5666666667 12.4803893433 119.2507021807 69.8826311526
NZW/LacJ m 78.9666666667 12.4803893433 103.6507021807 54.2826311526
PL/J f 92.15 15.2852928411 122.3816459011 61.9183540989
PL/J m 30.3333333333 12.4803893433 55.0173688474 5.6492978193
SM/J f 80.25 10.8083342204 101.6270018231 58.8729981769
SM/J m 70.15 10.8083342204 91.5270018231 48.7729981769


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
A/J both 64.25 8.8249679365 81.704248899 46.795751101
AKR/J both 89.85 10.8083342204 111.2270018231 68.4729981769
BALB/cByJ both 85.05 8.8249679365 102.504248899 67.595751101
BALB/cJ both 71.275 9.8666141026 90.7894435172 51.7605564828
BPL/1J both 64.55 8.8249679365 82.004248899 47.095751101
BTBR T+ Itpr3tf/J both 79.8666666667 9.8666141026 99.3811101839 60.3522231495
BXD1/TyJ both 94.3416666667 9.8666141026 113.8561101839 74.8272231495
BXD2/TyJ both 65.2333333333 8.8249679365 82.6875822324 47.7790844343
BXD31/TyJ both 87.0125 8.2550016169 103.3394548309 70.6855451691
BXD32/TyJ both 86.525 10.8083342204 107.9020018231 65.1479981769
BXD38/TyJ both 78.6833333333 8.8249679365 96.1375822324 61.2290844343
BXD42/TyJ both 82.7666666667 9.8666141026 102.2811101839 63.2522231495
BXD48a/RwwJ both 85.025 9.8666141026 104.5394435172 65.5105564828
BXD62/RwwJ both 86.575 9.8666141026 106.0894435172 67.0605564828
BXD65/RwwJ both 90.1833333333 8.8249679365 107.6375822324 72.7290844343
BXD77/RwwJ both 75.35 8.8249679365 92.804248899 57.895751101
BXD84/RwwJ both 78.2166666667 8.8249679365 95.6709155657 60.7624177676
BXD98/RwwJ both 96.2416666667 9.8666141026 115.7561101839 76.7272231495
C3HeB/FeJ both 75.7166666667 9.8666141026 95.2311101839 56.2022231495
C3H/HeJ both 64.0166666667 8.8249679365 81.4709155657 46.5624177676
C57BL/10J both 91.1333333333 8.8249679365 108.5875822324 73.6790844343
C57BL/6J both 90.6166666667 9.8666141026 110.1311101839 71.1022231495
C57BLKS/J both 66.6666666667 8.8249679365 84.1209155657 49.2124177676
C57BR/cdJ both 90.9833333333 8.8249679365 108.4375822324 73.5290844343
C58/J both 92.0166666667 8.8249679365 109.4709155657 74.5624177676
CBA/J both 83.75 8.8249679365 101.204248899 66.295751101
FVB/NJ both 79.7 9.8666141026 99.2144435172 60.1855564828
KK/HlJ both 63.3 8.8249679365 80.754248899 45.845751101
LP/J both 97.875 10.8083342204 119.2520018231 76.4979981769
MA/MyJ both 81.9 8.8249679365 99.354248899 64.445751101
MRL/MpJ both 77.1833333333 8.8249679365 94.6375822324 59.7290844343
NOD/ShiLtJ both 49.45 8.8249679365 66.904248899 31.995751101
NZB/BlNJ both 89.1 8.8249679365 106.554248899 71.645751101
NZO/HlLtJ both 82.3666666667 8.8249679365 99.8209155657 64.9124177676
NZW/LacJ both 86.7666666667 8.8249679365 104.2209155657 69.3124177676
PL/J both 61.2416666667 9.8666141026 80.7561101839 41.7272231495
SM/J both 75.2 7.6426464206 90.3158229505 60.0841770495




  GWAS USING LINEAR MIXED MODELS