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Project measure / variable:   Project1032   active_pct_d8_cocaine

ID, description, units MPD:111457   active_pct_d8_cocaine   percentage of lever presses that are active (intravenous self administration), cocaine   [%]  day 8  
cocaine study
Data set, strains Project1032   HMDP   66 strains     sex: both     age: 9-15wks
Procedure operant conditioning chamber
Ontology mappings


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  STRAIN COMPARISON PLOT
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Project1032 - percentage of lever presses that are active (intravenous self administration), cocaine day 8



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested61 strains62 strains
Mean of the strain means81.16   % 82.12   %
Median of the strain means85.25   % 86.34   %
SD of the strain means± 16.752 ± 19.253
Coefficient of variation (CV)0.2064 0.2344
Min–max range of strain means33.3   –   100.0   % 11.2   –   100.0   %
Mean sample size per strain2.1   mice 2.2   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 251.2156 251.2156 0.5423 0.463
strain 31 21632.0054 697.8066 1.5063 0.0634
sex:strain 31 20493.9999 661.0968 1.427 0.0923
Residuals 111 51423.0367 463.2706


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
Select table page:
Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ m 100.0 0.0   2   0.0 0.0 100.0, 100.0 0.93
129X1/SvJ f 100.0 0.0   1   0.0 0.0 100.0, 100.0 1.12
A/J f 80.97 22.832   3 13.182 0.282 55.0, 97.9 -0.01
A/J m 51.3 45.643   3 26.352 0.8897 9.5, 100.0 -1.6
AKR/J f 93.1 9.7581   2   6.9 0.1048 86.2, 100.0 0.71
AKR/J m 96.9 4.3841   2   3.1 0.0452 93.8, 100.0 0.77
BALB/cByJ f 89.17 8.308   3 4.7966 0.0932 80.0, 96.2 0.48
BALB/cByJ m 69.4 31.27   3 18.054 0.4506 37.5, 100.0 -0.66
BALB/cJ f 87.5 13.718   2   9.7 0.1568 77.8, 97.2 0.38
BALB/cJ m 73.57 16.746   3 9.6682 0.2276 63.6, 92.9 -0.44
BPL/1J f 59.97 36.77   3 21.229 0.6132 27.7, 100.0 -1.26
BPL/1J m 65.6 26.513   3 15.307 0.4042 41.5, 94.0 -0.86
BTBR T+ Itpr3tf/J f 100.0 0.0   1   0.0 0.0 100.0, 100.0 1.12
BTBR T+ Itpr3tf/J m 66.7 0.0   1   0.0 0.0 66.7, 66.7 -0.8
BXD100/RwwJ f 85.25 8.556   2   6.05 0.1004 79.2, 91.3 0.24
BXD100/RwwJ m 88.2 0.0   1   0.0 0.0 88.2, 88.2 0.32
BXD11/TyJ f 100.0 0.0   1   0.0 0.0 100.0, 100.0 1.12
BXD11/TyJ m 11.2 0.0   1   0.0 0.0 11.2, 11.2 -3.68
BXD15/TyJ f 87.3 21.997   3 12.7 0.252 61.9, 100.0 0.37
BXD15/TyJ m 100.0 0.0   1   0.0 0.0 100.0, 100.0 0.93
BXD1/TyJ f 100.0 0.0   2   0.0 0.0 100.0, 100.0 1.12
BXD1/TyJ m 93.1 8.2237   3 4.748 0.0883 84.0, 100.0 0.57
BXD21/TyJ f 77.7 0.0   1   0.0 0.0 77.7, 77.7 -0.21
BXD21/TyJ m 95.3 6.6468   2   4.7 0.0697 90.6, 100.0 0.68
BXD28/TyJ f 100.0 0.0   1   0.0 0.0 100.0, 100.0 1.12
BXD2/TyJ f 42.767 12.074   3 6.9707 0.2823 33.1, 56.3 -2.29
BXD2/TyJ m 81.63 28.418   3 16.407 0.3481 48.9, 100.0 -0.03
BXD31/TyJ f 94.23 8.8036   3 5.0828 0.0934 84.1, 100.0 0.78
BXD31/TyJ m 82.58 9.5472   4 4.7736 0.1156 76.5, 96.8 0.02
BXD32/TyJ f 93.75 8.8388   2   6.25 0.0943 87.5, 100.0 0.75
BXD32/TyJ m 81.6 9.3338   2   6.6 0.1144 75.0, 88.2 -0.03
BXD34/TyJ f 71.45 5.0205   2   3.55 0.0703 67.9, 75.0 -0.58
BXD34/TyJ m 89.2 0.0   1   0.0 0.0 89.2, 89.2 0.37
BXD38/TyJ f 83.13 6.4034   3 3.697 0.077 78.9, 90.5 0.12
BXD38/TyJ m 83.43 20.909   3 12.072 0.2506 59.3, 96.1 0.07
BXD39/TyJ f 58.3 0.0   1   0.0 0.0 58.3, 58.3 -1.36
BXD39/TyJ m 95.57 7.6788   3 4.4333 0.0803 86.7, 100.0 0.7
BXD40/TyJ m 82.1 27.861   3 16.086 0.3394 50.0, 100.0 0.0
BXD42/TyJ f 65.2 49.215   2   34.8 0.7548 30.4, 100.0 -0.95
BXD42/TyJ m 96.73 3.0353   3 1.7525 0.0314 94.0, 100.0 0.76
BXD48a/RwwJ f 98.2 2.5456   2   1.8 0.0259 96.4, 100.0 1.02
BXD48a/RwwJ m 74.67 25.17   3 14.532 0.3371 46.7, 95.5 -0.39
BXD50/RwwJ f 71.4 0.0   1   0.0 0.0 71.4, 71.4 -0.58
BXD50/RwwJ m 63.25 34.719   2   24.55 0.5489 38.7, 87.8 -0.98
BXD55/RwwJ f 93.5 6.6468   2   4.7 0.0711 88.8, 98.2 0.74
BXD55/RwwJ m 43.2 0.0   1   0.0 0.0 43.2, 43.2 -2.02
BXD56/RwwJ m 100.0 0.0   1   0.0 0.0 100.0, 100.0 0.93
BXD60/RwwJ f 98.3 0.0   1   0.0 0.0 98.3, 98.3 1.02
BXD60/RwwJ m 93.65 4.4548   2   3.15 0.0476 90.5, 96.8 0.6
BXD61/RwwJ f 65.57 53.28   3 30.76 0.8126 4.2, 100.0 -0.93
BXD61/RwwJ m 100.0 0.0   1   0.0 0.0 100.0, 100.0 0.93
BXD62/RwwJ f 93.95 8.556   2   6.05 0.0911 87.9, 100.0 0.76
BXD62/RwwJ m 87.05 18.314   2   12.95 0.2104 74.1, 100.0 0.26
BXD63/RwwJ f 50.0 0.0   1   0.0 0.0 50.0, 50.0 -1.86
BXD63/RwwJ m 79.3 0.0   1   0.0 0.0 79.3, 79.3 -0.15
BXD65/RwwJ f 73.73 25.672   3 14.822 0.3482 48.7, 100.0 -0.44
BXD65/RwwJ m 93.73 6.4578   3 3.7284 0.0689 87.1, 100.0 0.6
BXD68/RwwJ f 71.3 0.0   1   0.0 0.0 71.3, 71.3 -0.59
BXD68/RwwJ m 99.13 1.5011   3 0.86667 0.0151 97.4, 100.0 0.88
BXD69/RwwJ f 69.0 37.194   2   26.3 0.539 42.7, 95.3 -0.73
BXD70/RwwJ f 33.3 0.0   1   0.0 0.0 33.3, 33.3 -2.86
BXD70/RwwJ m 100.0 0.0   1   0.0 0.0 100.0, 100.0 0.93
BXD71/RwwJ f 64.9 0.0   1   0.0 0.0 64.9, 64.9 -0.97
BXD71/RwwJ m 58.25 21.284   2   15.05 0.3654 43.2, 73.3 -1.24
BXD73a/RwwJ f 86.2 19.516   2   13.8 0.2264 72.4, 100.0 0.3
BXD73a/RwwJ m 14.8 0.0   1   0.0 0.0 14.8, 14.8 -3.5
BXD75/RwwJ f 86.2 0.0   1   0.0 0.0 86.2, 86.2 0.3
BXD75/RwwJ m 84.6 21.779   2   15.4 0.2574 69.2, 100.0 0.13
BXD77/RwwJ f 60.35 44.901   2   31.75 0.744 28.6, 92.1 -1.24
BXD77/RwwJ m 86.27 11.756   3 6.7873 0.1363 72.9, 95.0 0.22
BXD84/RwwJ f 76.37 27.757   3 16.026 0.3635 45.8, 100.0 -0.29
BXD84/RwwJ m 79.67 16.303   3 9.4123 0.2046 63.2, 95.8 -0.13
BXD90/RwwJ m 94.35 0.77782   2   0.55 0.0082 93.8, 94.9 0.64
BXD98/RwwJ f 97.6 3.3941   2   2.4 0.0348 95.2, 100.0 0.98
BXD98/RwwJ m 95.4 4.7571   3 2.7465 0.0499 90.5, 100.0 0.69
BXD99/RwwJ f 70.4 0.0   1   0.0 0.0 70.4, 70.4 -0.64
BXD99/RwwJ m 84.4 0.0   1   0.0 0.0 84.4, 84.4 0.12
C3HeB/FeJ f 61.43 22.419   3 12.944 0.3649 38.5, 83.3 -1.18
C3HeB/FeJ m 91.7 7.3539   2   5.2 0.0802 86.5, 96.9 0.5
C3H/HeJ f 80.0 0.0   1   0.0 0.0 80.0, 80.0 -0.07
C3H/HeJ m 77.5 0.0   1   0.0 0.0 77.5, 77.5 -0.24
C57BL/10J f 96.97 2.6312   3 1.5191 0.0271 95.3, 100.0 0.94
C57BL/10J m 93.33 8.8444   3 5.1063 0.0948 83.3, 100.0 0.58
C57BL/6J f 92.85 10.112   2   7.15 0.1089 85.7, 100.0 0.7
C57BL/6J m 95.43 5.056   3 2.9191 0.053 90.0, 100.0 0.69
C57BLKS/J f 95.35 6.5761   2   4.65 0.069 90.7, 100.0 0.85
C57BLKS/J m 100.0 0.0   2   0.0 0.0 100.0, 100.0 0.93
C57BR/cdJ f 88.17 10.439   3 6.0267 0.1184 76.2, 95.4 0.42
C57BR/cdJ m 91.33 13.317   3 7.6884 0.1458 76.0, 100.0 0.48
C57L/J f 97.2 0.0   1   0.0 0.0 97.2, 97.2 0.96
C57L/J m 86.4 14.525   3 8.3859 0.1681 71.1, 100.0 0.22
C58/J f 91.3 6.0556   3 3.4962 0.0663 86.0, 97.9 0.61
C58/J m 87.73 16.372   3 9.4524 0.1866 69.0, 99.3 0.29
CBA/J f 52.17 37.957   3 21.914 0.7276 16.7, 92.2 -1.73
CBA/J m 93.9 6.7179   3 3.8786 0.0715 86.7, 100.0 0.61
DBA/1J f 80.97 5.208   3 3.0068 0.0643 75.0, 84.6 -0.01
DBA/1J m 100.0 0.0   1   0.0 0.0 100.0, 100.0 0.93
DBA/2J m 100.0 0.0   1   0.0 0.0 100.0, 100.0 0.93
FVB/NJ f 66.3 0.0   1   0.0 0.0 66.3, 66.3 -0.89
FVB/NJ m 69.05 3.3234   2   2.35 0.0481 66.7, 71.4 -0.68
I/LnJ f 98.6 1.9799   2   1.4 0.0201 97.2, 100.0 1.04
I/LnJ m 82.6 0.0   1   0.0 0.0 82.6, 82.6 0.02
KK/HlJ f 74.67 36.125   3 20.857 0.4838 33.3, 100.0 -0.39
KK/HlJ m 76.23 13.543   3 7.8189 0.1776 64.6, 91.1 -0.31
LP/J f 100.0 0.0   2   0.0 0.0 100.0, 100.0 1.12
LP/J m 100.0 0.0   2   0.0 0.0 100.0, 100.0 0.93
MA/MyJ f 62.17 36.514   3 21.082 0.5874 22.9, 95.1 -1.13
MA/MyJ m 98.67 1.2583   3 0.72648 0.0128 97.5, 100.0 0.86
MRL/MpJ f 90.6 12.021   2   8.5 0.1327 82.1, 99.1 0.56
MRL/MpJ m 77.77 38.509   3 22.233 0.4952 33.3, 100.0 -0.23
NOD/ShiLtJ f 47.367 30.834   3 17.802 0.651 15.3, 76.8 -2.02
NOD/ShiLtJ m 84.33 17.214   3 9.9387 0.2041 65.0, 98.0 0.11
NZB/BlNJ f 100.0 0.0   1   0.0 0.0 100.0, 100.0 1.12
NZB/BlNJ m 88.95 12.657   2   8.95 0.1423 80.0, 97.9 0.35
NZO/HlLtJ f 95.2 5.7   3 3.2909 0.0599 88.9, 100.0 0.84
NZO/HlLtJ m 68.1 51.18   3 29.551 0.7516 9.0, 98.1 -0.73
NZW/LacJ f 100.0 0.0   3 0.0 0.0 100.0, 100.0 1.12
NZW/LacJ m 81.8 0.0   1   0.0 0.0 81.8, 81.8 -0.02
PL/J f 83.35 17.748   2   12.55 0.2129 70.8, 95.9 0.13
PL/J m 31.2 15.109   3 8.7231 0.4843 21.4, 48.6 -2.64
SJL/J f 81.8 0.0   1   0.0 0.0 81.8, 81.8 0.04
SM/J f 84.2 11.151   4 5.5754 0.1324 69.7, 96.8 0.18
SM/J m 79.78 27.859   4 13.93 0.3492 38.0, 94.7 -0.12


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
A/J f 80.9666666667 12.4267265816 105.59105496 56.3422783733
A/J m 51.3 12.4267265816 75.9243882933 26.6756117067
AKR/J f 93.1 15.219569649 123.2585932734 62.9414067266
AKR/J m 96.9 15.219569649 127.0585932734 66.7414067266
BALB/cByJ f 89.1666666667 12.4267265816 113.79105496 64.5422783733
BALB/cByJ m 69.4 12.4267265816 94.0243882933 44.7756117067
BALB/cJ f 87.5 15.219569649 117.6585932734 57.3414067266
BALB/cJ m 73.5666666667 12.4267265816 98.19105496 48.9422783733
BPL/1J f 59.9666666667 12.4267265816 84.59105496 35.3422783733
BPL/1J m 65.6 12.4267265816 90.2243882933 40.9756117067
BXD1/TyJ f 100.0 15.219569649 130.1585932734 69.8414067266
BXD1/TyJ m 93.1 12.4267265816 117.7243882933 68.4756117067
BXD2/TyJ f 42.7666666667 12.4267265816 67.39105496 18.1422783733
BXD2/TyJ m 81.6333333333 12.4267265816 106.2577216267 57.00894504
BXD31/TyJ f 94.2333333333 12.4267265816 118.8577216267 69.60894504
BXD31/TyJ m 82.575 10.7618609055 103.9003458147 61.2496541853
BXD32/TyJ f 93.75 15.219569649 123.9085932734 63.5914067266
BXD32/TyJ m 81.6 15.219569649 111.7585932734 51.4414067266
BXD38/TyJ f 83.1333333333 12.4267265816 107.7577216267 58.50894504
BXD38/TyJ m 83.4333333333 12.4267265816 108.0577216267 58.80894504
BXD42/TyJ f 65.2 15.219569649 95.3585932734 35.0414067266
BXD42/TyJ m 96.7333333333 12.4267265816 121.3577216267 72.10894504
BXD48a/RwwJ f 98.2 15.219569649 128.3585932734 68.0414067266
BXD48a/RwwJ m 74.6666666667 12.4267265816 99.29105496 50.0422783733
BXD62/RwwJ f 93.95 15.219569649 124.1085932734 63.7914067266
BXD62/RwwJ m 87.05 15.219569649 117.2085932734 56.8914067266
BXD65/RwwJ f 73.7333333333 12.4267265816 98.3577216267 49.10894504
BXD65/RwwJ m 93.7333333333 12.4267265816 118.3577216267 69.10894504
BXD77/RwwJ f 60.35 15.219569649 90.5085932734 30.1914067266
BXD77/RwwJ m 86.2666666667 12.4267265816 110.89105496 61.6422783733
BXD84/RwwJ f 76.3666666667 12.4267265816 100.99105496 51.7422783733
BXD84/RwwJ m 79.6666666667 12.4267265816 104.29105496 55.0422783733
BXD98/RwwJ f 97.6 15.219569649 127.7585932734 67.4414067266
BXD98/RwwJ m 95.4 12.4267265816 120.0243882933 70.7756117067
C3HeB/FeJ f 61.4333333333 12.4267265816 86.0577216267 36.80894504
C3HeB/FeJ m 91.7 15.219569649 121.8585932734 61.5414067266
C57BL/10J f 96.9666666667 12.4267265816 121.59105496 72.3422783733
C57BL/10J m 93.3333333333 12.4267265816 117.9577216267 68.70894504
C57BL/6J f 92.85 15.219569649 123.0085932734 62.6914067266
C57BL/6J m 95.4333333333 12.4267265816 120.0577216267 70.80894504
C57BLKS/J f 95.35 15.219569649 125.5085932734 65.1914067266
C57BLKS/J m 100.0 15.219569649 130.1585932734 69.8414067266
C57BR/cdJ f 88.1666666667 12.4267265816 112.79105496 63.5422783733
C57BR/cdJ m 91.3333333333 12.4267265816 115.9577216267 66.70894504
C58/J f 91.3 12.4267265816 115.9243882933 66.6756117067
C58/J m 87.7333333333 12.4267265816 112.3577216267 63.10894504
CBA/J f 52.1666666667 12.4267265816 76.79105496 27.5422783733
CBA/J m 93.9 12.4267265816 118.5243882933 69.2756117067
KK/HlJ f 74.6666666667 12.4267265816 99.29105496 50.0422783733
KK/HlJ m 76.2333333333 12.4267265816 100.8577216267 51.60894504
LP/J f 100.0 15.219569649 130.1585932734 69.8414067266
LP/J m 100.0 15.219569649 130.1585932734 69.8414067266
MA/MyJ f 62.1666666667 12.4267265816 86.79105496 37.5422783733
MA/MyJ m 98.6666666667 12.4267265816 123.29105496 74.0422783733
MRL/MpJ f 90.6 15.219569649 120.7585932734 60.4414067266
MRL/MpJ m 77.7666666667 12.4267265816 102.39105496 53.1422783733
NOD/ShiLtJ f 47.3666666667 12.4267265816 71.99105496 22.7422783733
NOD/ShiLtJ m 84.3333333333 12.4267265816 108.9577216267 59.70894504
NZO/HlLtJ f 95.2 12.4267265816 119.8243882933 70.5756117067
NZO/HlLtJ m 68.1 12.4267265816 92.7243882933 43.4756117067
PL/J f 83.35 15.219569649 113.5085932734 53.1914067266
PL/J m 31.2 12.4267265816 55.8243882933 6.5756117067
SM/J f 84.2 10.7618609055 105.5253458147 62.8746541853
SM/J m 79.775 10.7618609055 101.1003458147 58.4496541853


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
A/J both 66.1333333333 8.7870226338 83.5454052781 48.7212613885
AKR/J both 95.0 10.7618609055 116.3253458147 73.6746541853
BALB/cByJ both 79.2833333333 8.7870226338 96.6954052781 61.8712613885
BALB/cJ both 80.5333333333 9.8241899645 100.0006215822 61.0660450845
BPL/1J both 62.7833333333 8.7870226338 80.1954052781 45.3712613885
BXD1/TyJ both 96.55 9.8241899645 116.0172882488 77.0827117512
BXD2/TyJ both 62.2 8.7870226338 79.6120719448 44.7879280552
BXD31/TyJ both 88.4041666667 8.2195070364 104.6916685695 72.1166647639
BXD32/TyJ both 87.675 10.7618609055 109.0003458147 66.3496541853
BXD38/TyJ both 83.2833333333 8.7870226338 100.6954052781 65.8712613885
BXD42/TyJ both 80.9666666667 9.8241899645 100.4339549155 61.4993784178
BXD48a/RwwJ both 86.4333333333 9.8241899645 105.9006215822 66.9660450845
BXD62/RwwJ both 90.5 10.7618609055 111.8253458147 69.1746541853
BXD65/RwwJ both 83.7333333333 8.7870226338 101.1454052781 66.3212613885
BXD77/RwwJ both 73.3083333333 9.8241899645 92.7756215822 53.8410450845
BXD84/RwwJ both 78.0166666667 8.7870226338 95.4287386115 60.6045947219
BXD98/RwwJ both 96.5 9.8241899645 115.9672882488 77.0327117512
C3HeB/FeJ both 76.5666666667 9.8241899645 96.0339549155 57.0993784178
C57BL/10J both 95.15 8.7870226338 112.5620719448 77.7379280552
C57BL/6J both 94.1416666667 9.8241899645 113.6089549155 74.6743784178
C57BLKS/J both 97.675 10.7618609055 119.0003458147 76.3496541853
C57BR/cdJ both 89.75 8.7870226338 107.1620719448 72.3379280552
C58/J both 89.5166666667 8.7870226338 106.9287386115 72.1045947219
CBA/J both 73.0333333333 8.7870226338 90.4454052781 55.6212613885
KK/HlJ both 75.45 8.7870226338 92.8620719448 58.0379280552
LP/J both 100.0 10.7618609055 121.3253458147 78.6746541853
MA/MyJ both 80.4166666667 8.7870226338 97.8287386115 63.0045947219
MRL/MpJ both 84.1833333333 9.8241899645 103.6506215822 64.7160450845
NOD/ShiLtJ both 65.85 8.7870226338 83.2620719448 48.4379280552
NZO/HlLtJ both 81.65 8.7870226338 99.0620719448 64.2379280552
PL/J both 57.275 9.8241899645 76.7422882488 37.8077117512
SM/J both 81.9875 7.6097848245 97.0667966367 66.9082033633




  GWAS USING LINEAR MIXED MODELS