Project measure / variable:   Project1032   active_pct_d3_cocaine

ID, description, units MPD:111452   active_pct_d3_cocaine   percentage of lever presses that are active (intravenous self administration), cocaine   [%]  day 3  
cocaine study
Data set, strains Project1032   HMDP   65 strains     sex: both     age: 9-15wks
Procedure operant conditioning chamber
Ontology mappings


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  STRAIN COMPARISON PLOT
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Project1032 - percentage of lever presses that are active (intravenous self administration), cocaine day 3



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested59 strains62 strains
Mean of the strain means74.69   % 71.35   %
Median of the strain means73.17   % 71.45   %
SD of the strain means± 17.654 ± 18.501
Coefficient of variation (CV)0.2364 0.2593
Min–max range of strain means26.7   –   100.0   % 21.4   –   100.0   %
Mean sample size per strain2.1   mice 2.3   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 515.956 515.956 0.8382 0.3618
strain 33 11730.5735 355.4719 0.5775 0.9647
sex:strain 33 25568.8666 774.8141 1.2587 0.1863
Residuals 117 72020.4458 615.5594


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
Select table page:
Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ m 62.75 52.68   2   37.25 0.8395 25.5, 100.0 -0.46
129X1/SvJ f 100.0 0.0   2   0.0 0.0 100.0, 100.0 1.43
A/J f 68.83 27.162   3 15.682 0.3946 37.5, 85.7 -0.33
A/J m 57.75 59.75   2   42.25 1.0346 15.5, 100.0 -0.74
AKR/J f 83.33 28.868   3 16.667 0.3464 50.0, 100.0 0.49
AKR/J m 78.4 21.452   3 12.385 0.2736 57.1, 100.0 0.38
BALB/cByJ f 73.17 20.618   3 11.904 0.2818 50.0, 89.5 -0.09
BALB/cByJ m 80.37 34.006   3 19.633 0.4231 41.1, 100.0 0.49
BALB/cJ f 75.27 21.914   3 12.652 0.2912 50.0, 89.1 0.03
BALB/cJ m 40.033 21.856   3 12.618 0.5459 15.4, 57.1 -1.69
BPL/1J f 91.63 10.11   3 5.8368 0.1103 80.4, 100.0 0.96
BPL/1J m 31.5 14.901   3 8.6031 0.473 14.5, 42.3 -2.15
BTBR T+ Itpr3tf/J f 45.0 7.0711   2   5.0 0.1571 40.0, 50.0 -1.68
BTBR T+ Itpr3tf/J m 89.3 15.132   2   10.7 0.1695 78.6, 100.0 0.97
BXD100/RwwJ f 50.0 0.0   2   0.0 0.0 50.0, 50.0 -1.4
BXD100/RwwJ m 60.0 0.0   1   0.0 0.0 60.0, 60.0 -0.61
BXD11/TyJ f 100.0 0.0   2   0.0 0.0 100.0, 100.0 1.43
BXD11/TyJ m 56.15 62.01   2   43.85 1.1044 12.3, 100.0 -0.82
BXD15/TyJ f 65.97 52.17   3 30.122 0.7909 5.9, 100.0 -0.49
BXD15/TyJ m 100.0 0.0   1   0.0 0.0 100.0, 100.0 1.55
BXD1/TyJ f 77.1 28.284   2   20.0 0.3669 57.1, 97.1 0.14
BXD1/TyJ m 87.6 11.195   3 6.4632 0.1278 75.0, 96.4 0.88
BXD21/TyJ f 30.0 0.0   1   0.0 0.0 30.0, 30.0 -2.53
BXD21/TyJ m 89.35 3.3234   2   2.35 0.0372 87.0, 91.7 0.97
BXD2/TyJ f 64.3 31.12   3 17.967 0.484 42.9, 100.0 -0.59
BXD2/TyJ m 70.8 29.256   3 16.891 0.4132 37.7, 93.2 -0.03
BXD31/TyJ f 92.7 1.6971   2   1.2 0.0183 91.5, 93.9 1.02
BXD31/TyJ m 68.72 28.066   4 14.033 0.4084 34.9, 100.0 -0.14
BXD32/TyJ f 66.65 23.547   2   16.65 0.3533 50.0, 83.3 -0.46
BXD32/TyJ m 67.3 30.879   3 17.828 0.4588 33.3, 93.6 -0.22
BXD34/TyJ f 59.6 1.8385   2   1.3 0.0308 58.3, 60.9 -0.85
BXD38/TyJ f 51.1 48.649   2   34.4 0.952 16.7, 85.5 -1.34
BXD38/TyJ m 65.57 51.47   3 29.716 0.785 6.4, 100.0 -0.31
BXD39/TyJ f 100.0 0.0   1   0.0 0.0 100.0, 100.0 1.43
BXD39/TyJ m 54.6 43.982   2   31.1 0.8055 23.5, 85.7 -0.91
BXD40/TyJ f 55.0 7.0711   2   5.0 0.1286 50.0, 60.0 -1.12
BXD40/TyJ m 97.83 3.7528   3 2.1667 0.0384 93.5, 100.0 1.43
BXD42/TyJ f 71.65 16.476   2   11.65 0.2299 60.0, 83.3 -0.17
BXD42/TyJ m 75.53 21.235   3 12.26 0.2811 61.9, 100.0 0.23
BXD48a/RwwJ f 72.5 31.82   2   22.5 0.4389 50.0, 95.0 -0.12
BXD48a/RwwJ m 70.87 23.195   3 13.392 0.3273 55.1, 97.5 -0.03
BXD50/RwwJ f 85.7 0.0   1   0.0 0.0 85.7, 85.7 0.62
BXD50/RwwJ m 59.95 40.517   2   28.65 0.6759 31.3, 88.6 -0.62
BXD55/RwwJ f 87.9 12.728   2   9.0 0.1448 78.9, 96.9 0.75
BXD55/RwwJ m 30.8 0.0   1   0.0 0.0 30.8, 30.8 -2.19
BXD56/RwwJ m 100.0 0.0   1   0.0 0.0 100.0, 100.0 1.55
BXD60/RwwJ f 100.0 0.0   1   0.0 0.0 100.0, 100.0 1.43
BXD60/RwwJ m 62.1 40.729   2   28.8 0.6559 33.3, 90.9 -0.5
BXD61/RwwJ f 70.0 14.142   2   10.0 0.202 60.0, 80.0 -0.27
BXD61/RwwJ m 21.4 0.0   1   0.0 0.0 21.4, 21.4 -2.7
BXD62/RwwJ f 60.0 0.0   1   0.0 0.0 60.0, 60.0 -0.83
BXD62/RwwJ m 80.0 28.284   2   20.0 0.3536 60.0, 100.0 0.47
BXD63/RwwJ m 40.0 0.0   1   0.0 0.0 40.0, 40.0 -1.69
BXD65/RwwJ f 81.87 16.157   3 9.3283 0.1974 69.0, 100.0 0.41
BXD65/RwwJ m 76.4 12.939   3 7.4702 0.1694 61.5, 84.8 0.27
BXD68/RwwJ m 86.2 18.56   3 10.716 0.2153 65.1, 100.0 0.8
BXD69/RwwJ f 92.3 0.0   1   0.0 0.0 92.3, 92.3 1.0
BXD70/RwwJ m 76.2 0.0   1   0.0 0.0 76.2, 76.2 0.26
BXD71/RwwJ f 80.0 0.0   1   0.0 0.0 80.0, 80.0 0.3
BXD71/RwwJ m 59.8 9.7581   2   6.9 0.1632 52.9, 66.7 -0.62
BXD73a/RwwJ f 82.05 25.385   2   17.95 0.3094 64.1, 100.0 0.42
BXD73a/RwwJ m 53.4 0.0   1   0.0 0.0 53.4, 53.4 -0.97
BXD75/RwwJ f 91.7 0.0   1   0.0 0.0 91.7, 91.7 0.96
BXD75/RwwJ m 67.55 14.071   2   9.95 0.2083 57.6, 77.5 -0.21
BXD77/RwwJ f 80.9 16.546   2   11.7 0.2045 69.2, 92.6 0.35
BXD77/RwwJ m 79.63 5.5896   3 3.2271 0.0702 73.2, 83.3 0.45
BXD84/RwwJ f 82.43 15.437   3 8.9126 0.1873 65.4, 95.5 0.44
BXD84/RwwJ m 59.6 32.192   3 18.586 0.5401 33.3, 95.5 -0.64
BXD90/RwwJ m 90.65 13.223   2   9.35 0.1459 81.3, 100.0 1.04
BXD98/RwwJ f 69.73 33.269   3 19.208 0.4771 33.3, 98.5 -0.28
BXD98/RwwJ m 71.07 9.1664   3 5.2922 0.129 60.7, 78.1 -0.02
BXD99/RwwJ f 26.7 0.0   1   0.0 0.0 26.7, 26.7 -2.72
BXD99/RwwJ m 100.0 0.0   1   0.0 0.0 100.0, 100.0 1.55
C3HeB/FeJ f 63.9 0.0   1   0.0 0.0 63.9, 63.9 -0.61
C3HeB/FeJ m 96.75 2.8991   2   2.05 0.03 94.7, 98.8 1.37
C3H/HeJ f 53.8 0.0   1   0.0 0.0 53.8, 53.8 -1.18
C3H/HeJ m 58.27 42.003   3 24.25 0.7209 16.0, 100.0 -0.71
C57BL/10J f 70.0 20.972   3 12.108 0.2996 55.9, 94.1 -0.27
C57BL/10J m 71.83 18.964   3 10.949 0.264 50.0, 84.2 0.03
C57BL/6J f 60.0 0.0   1   0.0 0.0 60.0, 60.0 -0.83
C57BL/6J m 72.7 24.408   3 14.092 0.3357 45.7, 93.2 0.07
C57BLKS/J f 90.13 14.731   3 8.5052 0.1634 73.2, 100.0 0.87
C57BLKS/J m 62.03 32.077   3 18.519 0.5171 25.0, 81.1 -0.5
C57BR/cdJ f 88.0 12.241   3 7.0671 0.1391 73.9, 95.9 0.75
C57BR/cdJ m 85.87 11.252   3 6.4962 0.131 73.5, 95.5 0.78
C57L/J f 89.7 0.0   1   0.0 0.0 89.7, 89.7 0.85
C57L/J m 88.93 8.8867   3 5.1307 0.0999 78.8, 95.4 0.95
C58/J f 87.33 5.3687   3 3.0996 0.0615 83.7, 93.5 0.72
C58/J m 85.83 5.9214   3 3.4187 0.069 81.6, 92.6 0.78
CBA/J f 45.0 32.787   3 18.93 0.7286 10.0, 75.0 -1.68
CBA/J m 90.67 2.1779   3 1.2574 0.024 88.9, 93.1 1.04
DBA/1J f 72.73 34.151   3 19.717 0.4695 33.3, 92.6 -0.11
DBA/1J m 94.4 0.0   1   0.0 0.0 94.4, 94.4 1.25
DBA/2J f 100.0 0.0   2   0.0 0.0 100.0, 100.0 1.43
DBA/2J m 50.0 0.0   1   0.0 0.0 50.0, 50.0 -1.15
FVB/NJ f 64.4 20.365   2   14.4 0.3162 50.0, 78.8 -0.58
FVB/NJ m 75.0 35.355   2   25.0 0.4714 50.0, 100.0 0.2
I/LnJ f 68.1 25.597   2   18.1 0.3759 50.0, 86.2 -0.37
I/LnJ m 100.0 0.0   1   0.0 0.0 100.0, 100.0 1.55
KK/HlJ f 85.0 13.229   3 7.6376 0.1556 75.0, 100.0 0.58
KK/HlJ m 82.13 12.108   3 6.9905 0.1474 68.2, 90.1 0.58
LP/J f 94.2 3.1113   2   2.2 0.033 92.0, 96.4 1.11
LP/J m 59.5 46.669   2   33.0 0.7844 26.5, 92.5 -0.64
MA/MyJ f 52.77 23.761   3 13.718 0.4503 28.6, 76.1 -1.24
MA/MyJ m 89.97 13.57   3 7.8346 0.1508 74.4, 99.3 1.01
MRL/MpJ f 70.7 29.274   2   20.7 0.4141 50.0, 91.4 -0.23
MRL/MpJ m 66.25 22.981   2   16.25 0.3469 50.0, 82.5 -0.28
NOD/ShiLtJ f 56.37 13.495   3 7.7911 0.2394 45.3, 71.4 -1.04
NOD/ShiLtJ m 58.27 23.05   3 13.308 0.3956 35.3, 81.4 -0.71
NZB/BlNJ f 100.0 0.0   1   0.0 0.0 100.0, 100.0 1.43
NZB/BlNJ m 76.8 30.016   3 17.33 0.3908 42.9, 100.0 0.29
NZO/HlLtJ f 85.5 19.92   3 11.501 0.233 62.5, 97.2 0.61
NZO/HlLtJ m 51.2 42.3   3 24.422 0.8262 25.0, 100.0 -1.09
NZW/LacJ f 85.7 20.223   2   14.3 0.236 71.4, 100.0 0.62
NZW/LacJ m 65.47 37.85   3 21.853 0.5782 25.0, 100.0 -0.32
PL/J f 70.1 1.8385   2   1.3 0.0262 68.8, 71.4 -0.26
PL/J m 49.55 35.143   2   24.85 0.7092 24.7, 74.4 -1.18
SJL/J f 100.0 0.0   1   0.0 0.0 100.0, 100.0 1.43
SJL/J m 100.0 0.0   1   0.0 0.0 100.0, 100.0 1.55
SM/J f 68.02 25.368   4 12.684 0.3729 33.3, 92.1 -0.38
SM/J m 73.17 21.045   4 10.522 0.2876 50.0, 95.5 0.1


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
A/J f 68.8333333333 14.3243308872 97.2019200416 40.4647466251
A/J m 57.75 17.5436507902 92.4942810796 23.0057189204
AKR/J f 83.3333333333 14.3243308872 111.7019200416 54.9647466251
AKR/J m 78.4 14.3243308872 106.7685867083 50.0314132917
BALB/cByJ f 73.1666666667 14.3243308872 101.5352533749 44.7980799584
BALB/cByJ m 80.3666666667 14.3243308872 108.7352533749 51.9980799584
BALB/cJ f 75.2666666667 14.3243308872 103.6352533749 46.8980799584
BALB/cJ m 40.0333333333 14.3243308872 68.4019200416 11.6647466251
BPL/1J f 91.6333333333 14.3243308872 120.0019200416 63.2647466251
BPL/1J m 31.5 14.3243308872 59.8685867083 3.1314132917
BTBR T+ Itpr3tf/J f 45.0 17.5436507902 79.7442810796 10.2557189204
BTBR T+ Itpr3tf/J m 89.3 17.5436507902 124.0442810796 54.5557189204
BXD11/TyJ f 100.0 17.5436507902 134.7442810796 65.2557189204
BXD11/TyJ m 56.15 17.5436507902 90.8942810796 21.4057189204
BXD1/TyJ f 77.1 17.5436507902 111.8442810796 42.3557189204
BXD1/TyJ m 87.6 14.3243308872 115.9685867083 59.2314132917
BXD2/TyJ f 64.3 14.3243308872 92.6685867083 35.9314132917
BXD2/TyJ m 70.8 14.3243308872 99.1685867083 42.4314132917
BXD31/TyJ f 92.7 17.5436507902 127.4442810796 57.9557189204
BXD31/TyJ m 68.725 12.4052344405 93.2929167588 44.1570832412
BXD32/TyJ f 66.65 17.5436507902 101.3942810796 31.9057189204
BXD32/TyJ m 67.3 14.3243308872 95.6685867083 38.9314132917
BXD38/TyJ f 51.1 17.5436507902 85.8442810796 16.3557189204
BXD38/TyJ m 65.5666666667 14.3243308872 93.9352533749 37.1980799584
BXD40/TyJ f 55.0 17.5436507902 89.7442810796 20.2557189204
BXD40/TyJ m 97.8333333333 14.3243308872 126.2019200416 69.4647466251
BXD42/TyJ f 71.65 17.5436507902 106.3942810796 36.9057189204
BXD42/TyJ m 75.5333333333 14.3243308872 103.9019200416 47.1647466251
BXD48a/RwwJ f 72.5 17.5436507902 107.2442810796 37.7557189204
BXD48a/RwwJ m 70.8666666667 14.3243308872 99.2352533749 42.4980799584
BXD65/RwwJ f 81.8666666667 14.3243308872 110.2352533749 53.4980799584
BXD65/RwwJ m 76.4 14.3243308872 104.7685867083 48.0314132917
BXD77/RwwJ f 80.9 17.5436507902 115.6442810796 46.1557189204
BXD77/RwwJ m 79.6333333333 14.3243308872 108.0019200416 51.2647466251
BXD84/RwwJ f 82.4333333333 14.3243308872 110.8019200416 54.0647466251
BXD84/RwwJ m 59.6 14.3243308872 87.9685867083 31.2314132917
BXD98/RwwJ f 69.7333333333 14.3243308872 98.1019200416 41.3647466251
BXD98/RwwJ m 71.0666666667 14.3243308872 99.4352533749 42.6980799584
C57BL/10J f 70.0 14.3243308872 98.3685867083 41.6314132917
C57BL/10J m 71.8333333333 14.3243308872 100.2019200416 43.4647466251
C57BLKS/J f 90.1333333333 14.3243308872 118.5019200416 61.7647466251
C57BLKS/J m 62.0333333333 14.3243308872 90.4019200416 33.6647466251
C57BR/cdJ f 88.0 14.3243308872 116.3685867083 59.6314132917
C57BR/cdJ m 85.8666666667 14.3243308872 114.2352533749 57.4980799584
C58/J f 87.3333333333 14.3243308872 115.7019200416 58.9647466251
C58/J m 85.8333333333 14.3243308872 114.2019200416 57.4647466251
CBA/J f 45.0 14.3243308872 73.3685867083 16.6314132917
CBA/J m 90.6666666667 14.3243308872 119.0352533749 62.2980799584
FVB/NJ f 64.4 17.5436507902 99.1442810796 29.6557189204
FVB/NJ m 75.0 17.5436507902 109.7442810796 40.2557189204
KK/HlJ f 85.0 14.3243308872 113.3685867083 56.6314132917
KK/HlJ m 82.1333333333 14.3243308872 110.5019200416 53.7647466251
LP/J f 94.2 17.5436507902 128.9442810796 59.4557189204
LP/J m 59.5 17.5436507902 94.2442810796 24.7557189204
MA/MyJ f 52.7666666667 14.3243308872 81.1352533749 24.3980799584
MA/MyJ m 89.9666666667 14.3243308872 118.3352533749 61.5980799584
MRL/MpJ f 70.7 17.5436507902 105.4442810796 35.9557189204
MRL/MpJ m 66.25 17.5436507902 100.9942810796 31.5057189204
NOD/ShiLtJ f 56.3666666667 14.3243308872 84.7352533749 27.9980799584
NOD/ShiLtJ m 58.2666666667 14.3243308872 86.6352533749 29.8980799584
NZO/HlLtJ f 85.5 14.3243308872 113.8685867083 57.1314132917
NZO/HlLtJ m 51.2 14.3243308872 79.5685867083 22.8314132917
NZW/LacJ f 85.7 17.5436507902 120.4442810796 50.9557189204
NZW/LacJ m 65.4666666667 14.3243308872 93.8352533749 37.0980799584
PL/J f 70.1 17.5436507902 104.8442810796 35.3557189204
PL/J m 49.55 17.5436507902 84.2942810796 14.8057189204
SM/J f 68.025 12.4052344405 92.5929167588 43.4570832412
SM/J m 73.175 12.4052344405 97.7429167588 48.6070832412


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
A/J both 63.2916666667 11.3243778904 85.7190036662 40.8643296671
AKR/J both 80.8666666667 10.1288315063 100.9262867008 60.8070466326
BALB/cByJ both 76.7666666667 10.1288315063 96.8262867008 56.7070466326
BALB/cJ both 57.65 10.1288315063 77.7096200341 37.5903799659
BPL/1J both 61.5666666667 10.1288315063 81.6262867008 41.5070466326
BTBR T+ Itpr3tf/J both 67.15 12.4052344405 91.7179167588 42.5820832412
BXD11/TyJ both 78.075 12.4052344405 102.6429167588 53.5070832412
BXD1/TyJ both 82.35 11.3243778904 104.7773369995 59.9226630005
BXD2/TyJ both 67.55 10.1288315063 87.6096200341 47.4903799659
BXD31/TyJ both 80.7125 10.7432481654 101.9889400312 59.4360599688
BXD32/TyJ both 66.975 11.3243778904 89.4023369995 44.5476630005
BXD38/TyJ both 58.3333333333 11.3243778904 80.7606703329 35.9059963338
BXD40/TyJ both 76.4166666667 11.3243778904 98.8440036662 53.9893296671
BXD42/TyJ both 73.5916666667 11.3243778904 96.0190036662 51.1643296671
BXD48a/RwwJ both 71.6833333333 11.3243778904 94.1106703329 49.2559963338
BXD65/RwwJ both 79.1333333333 10.1288315063 99.1929533674 59.0737132992
BXD77/RwwJ both 80.2666666667 11.3243778904 102.6940036662 57.8393296671
BXD84/RwwJ both 71.0166666667 10.1288315063 91.0762867008 50.9570466326
BXD98/RwwJ both 70.4 10.1288315063 90.4596200341 50.3403799659
C57BL/10J both 70.9166666667 10.1288315063 90.9762867008 50.8570466326
C57BLKS/J both 76.0833333333 10.1288315063 96.1429533674 56.0237132992
C57BR/cdJ both 86.9333333333 10.1288315063 106.9929533674 66.8737132992
C58/J both 86.5833333333 10.1288315063 106.6429533674 66.5237132992
CBA/J both 67.8333333333 10.1288315063 87.8929533674 47.7737132992
FVB/NJ both 69.7 12.4052344405 94.2679167588 45.1320832412
KK/HlJ both 83.5666666667 10.1288315063 103.6262867008 63.5070466326
LP/J both 76.85 12.4052344405 101.4179167588 52.2820832412
MA/MyJ both 71.3666666667 10.1288315063 91.4262867008 51.3070466326
MRL/MpJ both 68.475 12.4052344405 93.0429167588 43.9070832412
NOD/ShiLtJ both 57.3166666667 10.1288315063 77.3762867008 37.2570466326
NZO/HlLtJ both 68.35 10.1288315063 88.4096200341 48.2903799659
NZW/LacJ both 75.5833333333 11.3243778904 98.0106703329 53.1559963338
PL/J both 59.825 12.4052344405 84.3929167588 35.2570832412
SM/J both 70.6 8.7718253951 87.9721405398 53.2278594602




  GWAS USING LINEAR MIXED MODELS