Project measure / variable:   CSNA03   extinction_active_cc_s2

ID, description, units MPD:110401   extinction_active_cc_s2   extinction, active lever presses (intravenous self administration), CC   [n]  session 2  
cocaine study
Data set, strains CSNA03   CC w/par   53 strains     sex: both     age:
Procedure operant conditioning chamber
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  STRAIN COMPARISON PLOT
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CSNA03 - extinction, active lever presses (intravenous self administration), CC session 2



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested50 strains51 strains
Mean of the strain means193.7   n 85.84   n
Median of the strain means93.84   n 61.0   n
SD of the strain means± 390.4 ± 90.04
Coefficient of variation (CV)2.0151 1.049
Min–max range of strain means0.0   –   2397.0   n 0.0   –   498.0   n
Mean sample size per strain3.1   mice 3.5   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 805941.6146 805941.6146 5.3062 0.0222
strain 36 16424950.7743 456248.6326 3.0039 < 0.0001
sex:strain 36 7015432.0201 194873.1117 1.283 0.1427
Residuals 221 33567053.7266 151887.1209


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
Select table page:
Strain Sex Mean SD N mice SEM CV Min, Max Z score
A/J f 24.333 24.454   9 8.1513 1.005 4.0, 80.0 -0.43
A/J m 37.5 45.148   6 18.431 1.2039 6.0, 106.0 -0.54
C57BL/6J f 265.0 346.2   11 104.4 1.3065 5.0, 1241.0 0.18
C57BL/6J m 63.83 48.848   12 14.101 0.7652 16.0, 184.0 -0.24
CAST/EiJ f 121.0 0.0   1   0.0 0.0 121.0, 121.0 -0.19
CAST/EiJ m 44.0 8.4853   2   6.0 0.1928 38.0, 50.0 -0.46
CC001/UncJ f 84.33 90.74   3 52.39 1.0759 1.0, 181.0 -0.28
CC001/UncJ m 61.0 39.281   3 22.679 0.644 27.0, 104.0 -0.28
CC002/UncJ f 2397.0 3174.0   3 1833.0 1.3245 52.0, 6009.0 5.64
CC002/UncJ m 498.0 425.7   2   301.0 0.8548 197.0, 799.0 4.58
CC003/UncJ f 47.0 16.971   2   12.0 0.3611 35.0, 59.0 -0.38
CC003/UncJ m 37.5 44.095   4 22.047 1.1759 8.0, 103.0 -0.54
CC004/TauUncJ f 167.3 195.8   9 65.27 1.1701 11.0, 522.0 -0.07
CC004/TauUncJ m 301.1 227.3   19 52.14 0.7548 54.0, 990.0 2.39
CC005/TauUncJ f 63.75 87.64   4 43.822 1.3748 10.0, 194.0 -0.33
CC005/TauUncJ m 23.0 4.2426   2   3.0 0.1845 20.0, 26.0 -0.7
CC006/TauUncJ f 177.0 16.971   2   12.0 0.0959 165.0, 189.0 -0.04
CC006/TauUncJ m 105.5 149.2   2   105.5 1.4142 0.22
CC007/UncJ f 229.0 0.0   1   0.0 0.0 229.0, 229.0 0.09
CC007/UncJ m 49.667 56.41   3 32.57 1.1358 -0.4
CC008/GeniUncJ f 0.0 0.0   2   0.0 None -0.5
CC008/GeniUncJ m 68.0 14.142   2   10.0 0.208 58.0, 78.0 -0.2
CC009/UncJ f 94.67 110.5   3 63.81 1.1675 2.0, 217.0 -0.25
CC009/UncJ m 21.333 33.546   3 19.368 1.5725 -0.72
CC011/UncJ f 269.0 271.2   3 156.6 1.0082 55.0, 574.0 0.19
CC011/UncJ m 88.0 20.952   3 12.097 0.2381 70.0, 111.0 0.02
CC012/GeniUncJ f 110.0 0.0   1   0.0 0.0 110.0, 110.0 -0.21
CC012/GeniUncJ m 119.7 133.9   3 77.29 1.1187 26.0, 273.0 0.38
CC013/GeniUncJ f 167.3 121.8   3 70.3 0.7277 27.0, 245.0 -0.07
CC013/GeniUncJ m 116.7 20.984   3 12.115 0.1799 93.0, 133.0 0.34
CC015/UncJ f 30.0 0.0   1   0.0 0.0 30.0, 30.0 -0.42
CC015/UncJ m 50.0 0.0   1   0.0 0.0 50.0, 50.0 -0.4
CC016/GeniUncJ f 648.5 905.8   2   640.5 1.3968 8.0, 1289.0 1.17
CC016/GeniUncJ m 37.5 2.1213   2   1.5 0.0566 36.0, 39.0 -0.54
CC017/UncJ f 20.0 14.0   3 8.0829 0.7 6.0, 34.0 -0.45
CC017/UncJ m 5.0 2.9439   4 1.472 0.5888 2.0, 8.0 -0.9
CC018/UncJ f 257.7 182.1   3 105.1 0.7067 56.0, 410.0 0.16
CC018/UncJ m 104.6 46.361   5 20.733 0.4432 46.0, 160.0 0.21
CC019/TauUncJ f 178.2 240.2   5 107.4 1.3478 33.0, 604.0 -0.04
CC019/TauUncJ m 38.5 21.92   2   15.5 0.5694 23.0, 54.0 -0.53
CC020/GeniUncJ f 196.0 0.0   1   0.0 0.0 196.0, 196.0 0.01
CC023/GeniUncJ f 34.0 35.043   3 20.232 1.0307 -0.41
CC023/GeniUncJ m 60.67 64.93   3 37.489 1.0703 15.0, 135.0 -0.28
CC024/GeniUncJ f 56.5 79.9   2   56.5 1.4142 -0.35
CC024/GeniUncJ m 15.0 21.213   2   15.0 1.4142 -0.79
CC025/GeniUncJ f 42.0 52.33   2   37.0 1.2459 5.0, 79.0 -0.39
CC025/GeniUncJ m 149.0 0.0   1   0.0 0.0 149.0, 149.0 0.7
CC026/GeniUncJ f 22.0 8.6023   5 3.8471 0.391 10.0, 34.0 -0.44
CC026/GeniUncJ m 24.667 11.06   3 6.3857 0.4484 13.0, 35.0 -0.68
CC027/GeniUncJ f 427.3 575.6   3 332.3 1.3469 21.0, 1086.0 0.6
CC027/GeniUncJ m 132.5 250.4   4 125.2 1.8899 0.52
CC028/GeniUncJ f 143.5 70.32   4 35.158 0.49 90.0, 243.0 -0.13
CC028/GeniUncJ m 101.7 60.35   3 34.844 0.5936 48.0, 167.0 0.18
CC029/UncJ f 5.0 0.0   1   0.0 0.0 5.0, 5.0 -0.48
CC029/UncJ m 6.0 0.0   1   0.0 0.0 6.0, 6.0 -0.89
CC030/GeniUncJ f 222.5 72.83   2   51.5 0.3273 171.0, 274.0 0.07
CC030/GeniUncJ m 92.0 14.142   2   10.0 0.1537 82.0, 102.0 0.07
CC032/GeniUncJ f 56.67 17.616   3 10.171 0.3109 46.0, 77.0 -0.35
CC032/GeniUncJ m 162.5 185.1   4 92.53 1.1389 13.0, 395.0 0.85
CC033/GeniUncJ f 27.0 0.0   1   0.0 0.0 27.0, 27.0 -0.43
CC033/GeniUncJ m 72.0 0.0   1   0.0 0.0 72.0, 72.0 -0.15
CC035/UncJ f 59.0 21.213   2   15.0 0.3595 44.0, 74.0 -0.35
CC035/UncJ m 56.5 23.335   2   16.5 0.413 40.0, 73.0 -0.33
CC036/UncJ f 127.7 7.3711   3 4.2557 0.0577 122.0, 136.0 -0.17
CC036/UncJ m 171.0 220.6   2   156.0 1.2902 15.0, 327.0 0.95
CC037/TauUncJ f 33.0 0.0   1   0.0 0.0 33.0, 33.0 -0.41
CC037/TauUncJ m 0.0 0.0   1   0.0 None -0.95
CC040/TauUncJ f 78.5 101.1   2   71.5 1.2881 7.0, 150.0 -0.3
CC040/TauUncJ m 88.0 0.0   2   0.0 0.0 88.0, 88.0 0.02
CC041/TauUncJ f 31.0 52.83   3 30.501 1.7042 -0.42
CC041/TauUncJ m 2.5 4.6613   12 1.3456 1.8645 -0.93
CC043/GeniUncJ m 57.0 0.0   1   0.0 0.0 57.0, 57.0 -0.32
CC044/UncJ f 0.0 0.0   1   0.0 None -0.5
CC044/UncJ m 14.5 16.263   2   11.5 1.1216 3.0, 26.0 -0.79
CC051/TauUncJ f 93.0 0.0   1   0.0 0.0 93.0, 93.0 -0.26
CC051/TauUncJ m 60.0 47.032   3 27.154 0.7839 12.0, 106.0 -0.29
CC057/UncJ f 67.5 82.73   2   58.5 1.2257 9.0, 126.0 -0.32
CC057/UncJ m 10.5 6.364   2   4.5 0.6061 6.0, 15.0 -0.84
CC059/TauUncJ f 1482.0 1961.0   3 1132.0 1.3231 51.0, 3717.0 3.3
CC059/TauUncJ m 230.3 175.2   3 101.2 0.7609 102.0, 430.0 1.6
CC060/UncJ m 105.0 0.0   1   0.0 0.0 105.0, 105.0 0.21
CC061/GeniUncJ f 206.5 221.3   2   156.5 1.0718 50.0, 363.0 0.03
CC061/GeniUncJ m 221.5 231.2   2   163.5 1.0439 58.0, 385.0 1.51
CC068/TauUncJ f 0.5 0.70711   2   0.5 1.4142 -0.49
CC068/TauUncJ m 0.0 0.0   2   0.0 None -0.95
CC074/UncJ m 89.0 0.0   1   0.0 0.0 89.0, 89.0 0.04
CC078/TauUncJ f 304.5 102.5   2   72.5 0.3367 232.0, 377.0 0.28
CC078/TauUncJ m 269.7 171.0   3 98.74 0.6342 97.0, 439.0 2.04
CC079/TauUncJ f 119.0 117.4   2   83.0 0.9864 36.0, 202.0 -0.19
CC079/TauUncJ m 61.5 41.719   2   29.5 0.6784 32.0, 91.0 -0.27
CC080/TauUncJ f 6.0 7.0711   2   5.0 1.1785 1.0, 11.0 -0.48
CC084/TauJ f 147.5 33.234   2   23.5 0.2253 124.0, 171.0 -0.12
CC084/TauJ m 15.0 0.0   1   0.0 0.0 15.0, 15.0 -0.79
NOD/ShiLtJ f 117.2 150.0   11 45.213 1.2797 7.0, 503.0 -0.2
NOD/ShiLtJ m 78.0 81.1   7 30.652 1.0397 3.0, 211.0 -0.09
NZO/HlLtJ f 45.7 46.819   10 14.805 1.0245 -0.38
NZO/HlLtJ m 30.222 21.919   9 7.3063 0.7253 10.0, 80.0 -0.62
PWK/PhJ f 126.0 86.25   5 38.571 0.6845 40.0, 243.0 -0.17
PWK/PhJ m 105.7 60.2   7 22.755 0.5695 12.0, 182.0 0.22
WSB/EiJ f 58.0 36.77   2   26.0 0.634 32.0, 84.0 -0.35
WSB/EiJ m 25.2 16.392   5 7.3308 0.6505 15.0, 54.0 -0.67


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
A/J f 24.3333333333 129.9089941865 280.3522982194 -231.6856315527
A/J m 37.5 159.1053743776 351.0579142232 -276.0579142232
C57BL/6J f 265.0 117.5071065298 496.5778670206 33.4221329794
C57BL/6J m 63.8333333333 112.5044891456 285.5522607753 -157.8855941086
CC001/UncJ f 84.3333333333 225.0089782912 527.7711882172 -359.1045215505
CC001/UncJ m 61.0 225.0089782912 504.4378548839 -382.4378548839
CC002/UncJ f 2396.6666666667 225.0089782912 2840.1045215505 1953.2288117828
CC002/UncJ m 498.0 275.5785921792 1041.0982385499 -45.0982385499
CC003/UncJ f 47.0 275.5785921792 590.0982385499 -496.0982385499
CC003/UncJ m 37.5 194.8634912798 421.5284473291 -346.5284473291
CC004/TauUncJ f 167.3333333333 129.9089941865 423.3522982194 -88.6856315527
CC004/TauUncJ m 301.1052631579 89.4095017131 477.3095993003 124.9009270155
CC005/TauUncJ f 63.75 194.8634912798 447.7784473291 -320.2784473291
CC005/TauUncJ m 23.0 275.5785921792 566.0982385499 -520.0982385499
CC006/TauUncJ f 177.0 275.5785921792 720.0982385499 -366.0982385499
CC006/TauUncJ m 105.5 275.5785921792 648.5982385499 -437.5982385499
CC008/GeniUncJ f 0.0 275.5785921792 543.0982385499 -543.0982385499
CC008/GeniUncJ m 68.0 275.5785921792 611.0982385499 -475.0982385499
CC009/UncJ f 94.6666666667 225.0089782912 538.1045215505 -348.7711882172
CC009/UncJ m 21.3333333333 225.0089782912 464.7711882172 -422.1045215505
CC011/UncJ f 269.0 225.0089782912 712.4378548839 -174.4378548839
CC011/UncJ m 88.0 225.0089782912 531.4378548839 -355.4378548839
CC013/GeniUncJ f 167.3333333333 225.0089782912 610.7711882172 -276.1045215505
CC013/GeniUncJ m 116.6666666667 225.0089782912 560.1045215505 -326.7711882172
CC016/GeniUncJ f 648.5 275.5785921792 1191.5982385499 105.4017614501
CC016/GeniUncJ m 37.5 275.5785921792 580.5982385499 -505.5982385499
CC017/UncJ f 20.0 225.0089782912 463.4378548839 -423.4378548839
CC017/UncJ m 5.0 194.8634912798 389.0284473291 -379.0284473291
CC018/UncJ f 257.6666666667 225.0089782912 701.1045215505 -185.7711882172
CC018/UncJ m 104.6 174.2912051338 448.0854854086 -238.8854854086
CC019/TauUncJ f 178.2 174.2912051338 521.6854854086 -165.2854854086
CC019/TauUncJ m 38.5 275.5785921792 581.5982385499 -504.5982385499
CC023/GeniUncJ f 34.0 225.0089782912 477.4378548839 -409.4378548839
CC023/GeniUncJ m 60.6666666667 225.0089782912 504.1045215505 -382.7711882172
CC024/GeniUncJ f 56.5 275.5785921792 599.5982385499 -486.5982385499
CC024/GeniUncJ m 15.0 275.5785921792 558.0982385499 -528.0982385499
CC026/GeniUncJ f 22.0 174.2912051338 365.4854854086 -321.4854854086
CC026/GeniUncJ m 24.6666666667 225.0089782912 468.1045215505 -418.7711882172
CC027/GeniUncJ f 427.3333333333 225.0089782912 870.7711882172 -16.1045215505
CC027/GeniUncJ m 132.5 194.8634912798 516.5284473291 -251.5284473291
CC028/GeniUncJ f 143.5 194.8634912798 527.5284473291 -240.5284473291
CC028/GeniUncJ m 101.6666666667 225.0089782912 545.1045215505 -341.7711882172
CC030/GeniUncJ f 222.5 275.5785921792 765.5982385499 -320.5982385499
CC030/GeniUncJ m 92.0 275.5785921792 635.0982385499 -451.0982385499
CC032/GeniUncJ f 56.6666666667 225.0089782912 500.1045215505 -386.7711882172
CC032/GeniUncJ m 162.5 194.8634912798 546.5284473291 -221.5284473291
CC035/UncJ f 59.0 275.5785921792 602.0982385499 -484.0982385499
CC035/UncJ m 56.5 275.5785921792 599.5982385499 -486.5982385499
CC036/UncJ f 127.6666666667 225.0089782912 571.1045215505 -315.7711882172
CC036/UncJ m 171.0 275.5785921792 714.0982385499 -372.0982385499
CC040/TauUncJ f 78.5 275.5785921792 621.5982385499 -464.5982385499
CC040/TauUncJ m 88.0 275.5785921792 631.0982385499 -455.0982385499
CC041/TauUncJ f 31.0 225.0089782912 474.4378548839 -412.4378548839
CC041/TauUncJ m 2.5 112.5044891456 224.2189274419 -219.2189274419
CC057/UncJ f 67.5 275.5785921792 610.5982385499 -475.5982385499
CC057/UncJ m 10.5 275.5785921792 553.5982385499 -532.5982385499
CC059/TauUncJ f 1482.0 225.0089782912 1925.4378548839 1038.5621451161
CC059/TauUncJ m 230.3333333333 225.0089782912 673.7711882172 -213.1045215505
CC061/GeniUncJ f 206.5 275.5785921792 749.5982385499 -336.5982385499
CC061/GeniUncJ m 221.5 275.5785921792 764.5982385499 -321.5982385499
CC068/TauUncJ f 0.5 275.5785921792 543.5982385499 -542.5982385499
CC068/TauUncJ m 0.0 275.5785921792 543.0982385499 -543.0982385499
CC078/TauUncJ f 304.5 275.5785921792 847.5982385499 -238.5982385499
CC078/TauUncJ m 269.6666666667 225.0089782912 713.1045215505 -173.7711882172
CC079/TauUncJ f 119.0 275.5785921792 662.0982385499 -424.0982385499
CC079/TauUncJ m 61.5 275.5785921792 604.5982385499 -481.5982385499
NOD/ShiLtJ f 117.1818181818 117.5071065298 348.7596852024 -114.3960488388
NOD/ShiLtJ m 78.0 147.3029535806 368.2982194306 -212.2982194306
NZO/HlLtJ f 45.7 123.2424930513 288.5809159716 -197.1809159716
NZO/HlLtJ m 30.2222222222 129.9089941865 286.2411871083 -225.7967426638
PWK/PhJ f 126.0 174.2912051338 469.4854854086 -217.4854854086
PWK/PhJ m 105.7142857143 147.3029535806 396.0125051449 -184.5839337163
WSB/EiJ f 58.0 275.5785921792 601.0982385499 -485.0982385499
WSB/EiJ m 25.2 174.2912051338 368.6854854086 -318.2854854086


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
A/J both 30.9166666667 102.7020775427 233.3174299763 -171.484096643
C57BL/6J both 164.4166666667 81.3406112636 324.7191863598 4.1141469736
CC001/UncJ both 72.6666666667 159.1053743776 386.2245808899 -240.8912475565
CC002/UncJ both 1447.3333333333 177.8852163469 1797.9017388764 1096.7649277903
CC003/UncJ both 42.25 168.7567337184 374.8283911629 -290.3283911629
CC004/TauUncJ both 234.2192982456 78.851768793 389.6169160336 78.8216804576
CC005/TauUncJ both 43.375 168.7567337184 375.9533911629 -289.2033911629
CC006/TauUncJ both 141.25 194.8634912798 525.2784473291 -242.7784473291
CC008/GeniUncJ both 34.0 194.8634912798 418.0284473291 -350.0284473291
CC009/UncJ both 58.0 159.1053743776 371.5579142232 -255.5579142232
CC011/UncJ both 178.5 159.1053743776 492.0579142232 -135.0579142232
CC013/GeniUncJ both 142.0 159.1053743776 455.5579142232 -171.5579142232
CC016/GeniUncJ both 343.0 194.8634912798 727.0284473291 -41.0284473291
CC017/UncJ both 12.5 148.8294498288 305.8065714837 -280.8065714837
CC018/UncJ both 181.1333333333 142.3081730775 461.5880577678 -99.3213911011
CC019/TauUncJ both 108.35 163.0344937847 429.6512509322 -212.9512509322
CC023/GeniUncJ both 47.3333333333 159.1053743776 360.8912475565 -266.2245808899
CC024/GeniUncJ both 35.75 194.8634912798 419.7784473291 -348.2784473291
CC026/GeniUncJ both 23.3333333333 142.3081730775 303.7880577678 -257.1213911011
CC027/GeniUncJ both 279.9166666667 148.8294498288 573.2232381503 -13.389904817
CC028/GeniUncJ both 122.5833333333 148.8294498288 415.889904817 -170.7232381503
CC030/GeniUncJ both 157.25 194.8634912798 541.2784473291 -226.7784473291
CC032/GeniUncJ both 109.5833333333 148.8294498288 402.889904817 -183.7232381503
CC035/UncJ both 57.75 194.8634912798 441.7784473291 -326.2784473291
CC036/UncJ both 149.3333333333 177.8852163469 499.9017388764 -201.2350722097
CC040/TauUncJ both 83.25 194.8634912798 467.2784473291 -300.7784473291
CC041/TauUncJ both 16.75 125.7838427517 264.6392968292 -231.1392968292
CC057/UncJ both 39.0 194.8634912798 423.0284473291 -345.0284473291
CC059/TauUncJ both 856.1666666667 159.1053743776 1169.7245808899 542.6087524435
CC061/GeniUncJ both 214.0 194.8634912798 598.0284473291 -170.0284473291
CC068/TauUncJ both 0.25 194.8634912798 384.2784473291 -383.7784473291
CC078/TauUncJ both 287.0833333333 177.8852163469 637.6517388764 -63.4850722097
CC079/TauUncJ both 90.25 194.8634912798 474.2784473291 -293.7784473291
NOD/ShiLtJ both 97.5909090909 94.215285674 283.266274109 -88.0844559272
NZO/HlLtJ both 37.9611111111 89.5335954601 214.4100057836 -138.4877835613
PWK/PhJ both 115.8571428571 114.100377213 340.7211767148 -109.0068910005
WSB/EiJ both 41.6 163.0344937847 362.9012509322 -279.7012509322




GWAS analysis not available: Strain panel must be either Inbred, HMDP, BXD, BXH, CXB, or AXB/BXA