Project measure / variable:   CSNA03   infusions_cc_0p056

ID, description, units MPD:110397   infusions_cc_0p056   dose response, mean number of infusions (intravenous self administration) on last two stabilized sessions, CC   [n]  0.056 mg/kg  
cocaine study
Data set, strains CSNA03   CC w/par   10 strains     sex: both     age:
Procedure operant conditioning chamber
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  STRAIN COMPARISON PLOT
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CSNA03 - dose response, mean number of infusions (intravenous self administration) on last two stabilized sessions, CC 0.056 mg/kg



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested10 strains10 strains
Mean of the strain means64.89   n 75.81   n
Median of the strain means68.47   n 70.38   n
SD of the strain means± 39.876 ± 41.695
Coefficient of variation (CV)0.6145 0.55
Min–max range of strain means11.4   –   124.7   n 20.0   –   155.3   n
Mean sample size per strain7.0   mice 6.8   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 5577.85 5577.85 4.3412 0.0395
strain 7 113020.3722 16145.7675 12.5663 < 0.0001
sex:strain 7 18442.789 2634.6841 2.0506 0.0549
Residuals 111 142618.3559 1284.8501


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
A/J f 39.322 26.197   9 8.7324 0.6662 -0.64
A/J m 77.76 52.94   7 20.011 0.6809 16.0, 180.0 0.05
C57BL/6J f 105.2 42.751   11 12.89 0.4065 53.0, 181.5 1.01
C57BL/6J m 79.69 35.092   11 10.581 0.4404 35.5, 139.5 0.09
CAST/EiJ f 92.0 41.012   2   29.0 0.4458 63.0, 121.0 0.68
CAST/EiJ m 63.0 23.754   3 13.714 0.377 39.5, 87.0 -0.31
CC004/TauUncJ f 124.7 44.246   8 15.643 0.3549 57.8, 201.5 1.5
CC004/TauUncJ m 155.3 30.055   8 10.626 0.1935 115.0, 195.5 1.91
CC026/GeniUncJ f 29.7 23.012   5 10.292 0.7748 11.5, 70.0 -0.88
CC026/GeniUncJ m 30.333 7.2858   3 4.2065 0.2402 23.5, 38.0 -1.09
CC041/TauUncJ f 13.722 23.193   3 13.39 1.6902 -1.28
CC041/TauUncJ m 20.0 0.0   1   0.0 0.0 20.0, 20.0 -1.34
NOD/ShiLtJ f 71.01 34.468   10 10.9 0.4854 22.0, 134.0 0.15
NOD/ShiLtJ m 89.3 45.193   8 15.978 0.5061 5.2, 134.0 0.32
NZO/HlLtJ f 65.94 31.478   12 9.0871 0.4774 10.0, 112.5 0.03
NZO/HlLtJ m 59.81 31.48   11 9.4917 0.5263 -0.38
PWK/PhJ f 95.94 39.453   9 13.151 0.4112 44.5, 165.5 0.78
PWK/PhJ m 130.4 26.677   10 8.4359 0.2045 91.0, 183.0 1.31
WSB/EiJ f 11.4 0.0   1   0.0 0.0 11.4, 11.4 -1.34
WSB/EiJ m 52.5 42.137   6 17.202 0.8026 19.0, 130.0 -0.56


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
A/J f 39.3222222222 11.9482683686 62.998513626 15.6459308185
A/J m 77.7571428571 13.5480628719 104.6035338669 50.9107518474
C57BL/6J f 105.1636363636 10.8076153835 126.5796477309 83.7476249963
C57BL/6J m 79.6909090909 10.8076153835 101.1069204582 58.2748977236
CAST/EiJ f 92.0 25.3461047606 142.2249986149 41.7750013851
CAST/EiJ m 63.0 20.6950078768 104.0085396461 21.9914603539
CC004/TauUncJ f 124.6625 12.6730523803 149.7749993074 99.5500006926
CC004/TauUncJ m 155.3125 12.6730523803 180.4249993074 130.2000006926
CC026/GeniUncJ f 29.7 16.0302841713 61.4650782203 -2.0650782203
CC026/GeniUncJ m 30.3333333333 20.6950078768 71.3418729795 -10.6752063128
NOD/ShiLtJ f 71.01 11.3351226419 93.4713022145 48.5486977855
NOD/ShiLtJ m 89.3 12.6730523803 114.4124993074 64.1875006926
NZO/HlLtJ f 65.9416666667 10.3475039384 86.4459364897 45.4373968436
NZO/HlLtJ m 59.8090909091 10.8076153835 81.2251022764 38.3930795418
PWK/PhJ f 95.9444444444 11.9482683686 119.6207358482 72.2681530407
PWK/PhJ m 130.45 11.3351226419 152.9113022145 107.9886977855


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
A/J both 58.5396825397 9.0320419146 76.4372765462 40.6420885332
C57BL/6J both 92.4272727273 7.6421381262 107.5706795911 77.2838658635
CAST/EiJ both 77.5 16.3608402715 109.9200971998 45.0799028002
CC004/TauUncJ both 139.9875 8.9612012764 157.7447185528 122.2302814472
CC026/GeniUncJ both 30.0166666667 13.0886722172 55.9527444265 4.0805889069
NOD/ShiLtJ both 80.155 8.5013419814 97.0009766609 63.3090233391
NZO/HlLtJ both 62.8753787879 7.4812329872 77.6999413772 48.0508161985
PWK/PhJ both 113.1972222222 8.2347756848 129.5149799711 96.8794644733




GWAS analysis not available: Strain panel must be either Inbred, HMDP, BXD, BXH, CXB, or AXB/BXA