Project measure / variable:   CSNA03   infusions_cc_0p32

ID, description, units MPD:110394   infusions_cc_0p32   dose response, mean number of infusions (intravenous self administration) on last two stabilized sessions, CC   [n]  0.32 mg/kg  
cocaine study
Data set, strains CSNA03   CC w/par   55 strains     sex: both     age:
Procedure operant conditioning chamber
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  STRAIN COMPARISON PLOT
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CSNA03 - dose response, mean number of infusions (intravenous self administration) on last two stabilized sessions, CC 0.32 mg/kg



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested53 strains51 strains
Mean of the strain means67.81   n 62.86   n
Median of the strain means70.0   n 58.83   n
SD of the strain means± 37.943 ± 37.946
Coefficient of variation (CV)0.5596 0.6037
Min–max range of strain means2.5   –   162.2   n 0.0   –   195.5   n
Mean sample size per strain3.7   mice 4.1   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 4794.6811 4794.6811 3.009 0.0838
strain 43 315935.6031 7347.3396 4.611 < 0.0001
sex:strain 43 72551.4704 1687.2435 1.0589 0.3796
Residuals 297 473255.4618 1593.4527


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
Select table page:
Strain Sex Mean SD N mice SEM CV Min, Max Z score
A/J f 85.9 59.69   11 17.998 0.6949 10.4, 195.5 0.48
A/J m 101.3 59.63   8 21.084 0.5884 22.667, 214.5 1.01
C57BL/6J f 90.35 26.096   13 7.2378 0.2888 47.0, 132.5 0.59
C57BL/6J m 66.23 22.212   13 6.1604 0.3354 39.5, 117.0 0.09
CAST/EiJ f 79.04 47.101   5 21.064 0.5959 15.5, 138.0 0.3
CAST/EiJ m 50.2 34.97   4 17.485 0.6966 21.5, 95.5 -0.33
CC001/UncJ f 162.2 72.17   3 41.668 0.445 85.0, 228.0 2.49
CC001/UncJ m 111.9 48.89   4 24.445 0.437 50.0, 169.5 1.29
CC002/UncJ f 105.5 81.31   3 46.942 0.7707 40.0, 196.5 0.99
CC002/UncJ m 95.25 61.87   2   43.75 0.6496 51.5, 139.0 0.85
CC003/UncJ f 51.75 2.4749   2   1.75 0.0478 50.0, 53.5 -0.42
CC003/UncJ m 29.575 15.159   4 7.5794 0.5126 17.8, 51.0 -0.88
CC004/TauUncJ f 83.41 50.83   11 15.327 0.6095 30.5, 212.5 0.41
CC004/TauUncJ m 94.63 30.726   22 6.5507 0.3247 44.0, 176.5 0.84
CC005/TauUncJ f 76.75 19.081   4 9.5405 0.2486 57.5, 102.0 0.24
CC005/TauUncJ m 106.0 37.385   3 21.584 0.3528 81.5, 149.0 1.14
CC006/TauUncJ f 54.25 8.1317   2   5.75 0.1499 48.5, 60.0 -0.36
CC006/TauUncJ m 84.75 119.9   2   84.75 1.4142 0.58
CC007/UncJ f 62.25 22.274   2   15.75 0.3578 46.5, 78.0 -0.15
CC007/UncJ m 59.1 58.38   3 33.708 0.9879 5.8, 121.5 -0.1
CC008/GeniUncJ f 19.25 16.617   2   11.75 0.8632 7.5, 31.0 -1.28
CC008/GeniUncJ m 34.5 7.0711   2   5.0 0.205 29.5, 39.5 -0.75
CC009/UncJ f 46.0 43.578   3 25.159 0.9473 1.0, 88.0 -0.57
CC009/UncJ m 29.9 29.902   3 17.264 1.0001 0.2, 60.0 -0.87
CC011/UncJ f 61.2 32.314   5 14.451 0.528 28.5, 115.0 -0.17
CC011/UncJ m 82.1 86.87   5 38.848 1.058 29.5, 236.0 0.51
CC012/GeniUncJ f 110.2 39.952   2   28.25 0.3624 82.0, 138.5 1.12
CC012/GeniUncJ m 38.033 46.202   3 26.675 1.2148 1.6, 90.0 -0.65
CC013/GeniUncJ f 99.17 54.21   3 31.3 0.5467 49.5, 157.0 0.83
CC013/GeniUncJ m 37.833 9.5699   3 5.5252 0.2529 30.0, 48.5 -0.66
CC015/UncJ f 48.5 62.93   2   44.5 1.2976 4.0, 93.0 -0.51
CC015/UncJ m 58.5 0.0   1   0.0 0.0 58.5, 58.5 -0.11
CC016/GeniUncJ f 133.9 147.2   2   104.1 1.0995 29.8, 238.0 1.74
CC016/GeniUncJ m 80.25 23.688   2   16.75 0.2952 63.5, 97.0 0.46
CC017/UncJ f 97.33 65.06   3 37.561 0.6684 44.5, 170.0 0.78
CC017/UncJ m 37.375 38.171   4 19.086 1.0213 4.5, 80.5 -0.67
CC018/UncJ f 145.7 106.1   3 61.27 0.7286 27.0, 231.5 2.05
CC018/UncJ m 74.2 47.675   5 21.321 0.6425 21.0, 142.5 0.3
CC019/TauUncJ f 95.8 28.162   5 12.594 0.294 65.5, 139.5 0.74
CC019/TauUncJ m 92.33 14.268   3 8.2378 0.1545 81.5, 108.5 0.78
CC020/GeniUncJ f 84.0 0.0   1   0.0 0.0 84.0, 84.0 0.43
CC023/GeniUncJ f 21.5 15.562   4 7.7809 0.7238 2.0, 39.5 -1.22
CC023/GeniUncJ m 72.23 49.354   3 28.495 0.6833 31.2, 127.0 0.25
CC024/GeniUncJ f 74.75 105.7   2   74.75 1.4142 0.18
CC024/GeniUncJ m 30.9 43.699   2   30.9 1.4142 -0.84
CC025/GeniUncJ f 55.7 42.851   2   30.3 0.7693 25.4, 86.0 -0.32
CC025/GeniUncJ m 49.25 13.081   2   9.25 0.2656 40.0, 58.5 -0.36
CC026/GeniUncJ f 34.4 15.221   5 6.807 0.4425 21.0, 55.5 -0.88
CC026/GeniUncJ m 30.0 25.254   3 14.58 0.8418 5.0, 55.5 -0.87
CC027/GeniUncJ f 73.5 42.835   4 21.417 0.5828 22.0, 110.5 0.15
CC027/GeniUncJ m 83.38 12.411   5 5.5502 0.1488 62.5, 94.0 0.54
CC028/GeniUncJ f 55.96 16.408   5 7.338 0.2932 36.0, 75.5 -0.31
CC028/GeniUncJ m 56.0 16.559   6 6.7602 0.2957 25.0, 71.0 -0.18
CC029/UncJ f 2.5 0.0   1   0.0 0.0 2.5, 2.5 -1.72
CC029/UncJ m 44.0 0.0   1   0.0 0.0 44.0, 44.0 -0.5
CC030/GeniUncJ f 78.25 35.002   2   24.75 0.4473 53.5, 103.0 0.28
CC030/GeniUncJ m 84.25 13.081   2   9.25 0.1553 75.0, 93.5 0.56
CC032/GeniUncJ f 80.17 10.372   3 5.9884 0.1294 69.0, 89.5 0.33
CC032/GeniUncJ m 26.875 8.3404   4 4.1702 0.3103 15.5, 35.5 -0.95
CC033/GeniUncJ f 18.5 0.0   1   0.0 0.0 18.5, 18.5 -1.3
CC033/GeniUncJ m 60.65 32.315   2   22.85 0.5328 37.8, 83.5 -0.06
CC035/UncJ f 57.57 27.667   3 15.974 0.4806 26.2, 78.5 -0.27
CC035/UncJ m 42.45 11.243   2   7.95 0.2649 34.5, 50.4 -0.54
CC036/UncJ f 68.83 26.502   3 15.301 0.385 42.5, 95.5 0.03
CC036/UncJ m 37.25 13.789   2   9.75 0.3702 27.5, 47.0 -0.67
CC037/TauUncJ f 4.8 0.0   1   0.0 0.0 4.8, 4.8 -1.66
CC037/TauUncJ m 0.0 0.0   1   0.0 None -1.66
CC040/TauUncJ f 54.25 22.274   2   15.75 0.4106 38.5, 70.0 -0.36
CC040/TauUncJ m 101.2 30.193   2   21.35 0.2985 79.8, 122.5 1.01
CC041/TauUncJ f 6.1667 13.325   5 5.9591 2.1608 -1.62
CC041/TauUncJ m 5.725 16.866   12 4.8687 2.946 -1.51
CC043/GeniUncJ m 26.25 15.91   2   11.25 0.6061 15.0, 37.5 -0.96
CC044/UncJ f 10.25 14.496   2   10.25 1.4142 -1.52
CC044/UncJ m 3.5 3.2527   2   2.3 0.9293 1.2, 5.8 -1.56
CC045/GeniUncJ f 142.5 0.0   1   0.0 0.0 142.5, 142.5 1.97
CC051/TauUncJ f 68.75 20.86   2   14.75 0.3034 54.0, 83.5 0.02
CC051/TauUncJ m 58.83 8.5196   3 4.9188 0.1448 50.0, 67.0 -0.11
CC057/UncJ f 56.5 41.719   2   29.5 0.7384 27.0, 86.0 -0.3
CC057/UncJ m 25.0 11.314   2   8.0 0.4525 17.0, 33.0 -1.0
CC059/TauUncJ f 109.2 32.095   4 16.047 0.2938 73.0, 142.5 1.09
CC059/TauUncJ m 91.0 27.143   3 15.671 0.2983 60.0, 110.5 0.74
CC060/UncJ m 40.5 0.0   1   0.0 0.0 40.5, 40.5 -0.59
CC061/GeniUncJ f 70.5 25.456   2   18.0 0.3611 52.5, 88.5 0.07
CC061/GeniUncJ m 149.2 59.04   2   41.75 0.3956 107.5, 191.0 2.28
CC068/TauUncJ f 14.35 28.434   4 14.217 1.9815 -1.41
CC068/TauUncJ m 0.6 0.84853   2   0.6 1.4142 -1.64
CC074/UncJ f 7.4 0.0   1   0.0 0.0 7.4, 7.4 -1.59
CC074/UncJ m 195.5 0.0   1   0.0 0.0 195.5, 195.5 3.5
CC075/UncJ f 26.5 0.0   1   0.0 0.0 26.5, 26.5 -1.09
CC078/TauUncJ f 100.8 13.789   2   9.75 0.1369 91.0, 110.5 0.87
CC078/TauUncJ m 92.5 49.932   3 28.829 0.5398 48.0, 146.5 0.78
CC079/TauUncJ f 70.0 20.506   2   14.5 0.2929 55.5, 84.5 0.06
CC079/TauUncJ m 77.75 15.91   2   11.25 0.2046 66.5, 89.0 0.39
CC080/TauUncJ f 71.9 28.709   2   20.3 0.3993 51.6, 92.2 0.11
CC084/TauJ f 108.9 60.95   2   43.1 0.5597 65.8, 152.0 1.08
CC084/TauJ m 64.17 3.4034   3 1.965 0.053 61.5, 68.0 0.03
NOD/ShiLtJ f 57.2 25.473   13 7.0651 0.4453 13.8, 116.0 -0.28
NOD/ShiLtJ m 58.24 39.001   9 13.0 0.6696 -0.12
NZO/HlLtJ f 74.77 39.943   13 11.078 0.5342 22.5, 162.5 0.18
NZO/HlLtJ m 74.36 25.377   11 7.6515 0.3413 35.0, 113.5 0.3
PWK/PhJ f 105.9 42.025   11 12.671 0.3968 55.5, 181.5 1.0
PWK/PhJ m 124.0 53.64   10 16.961 0.4327 75.0, 256.0 1.61
WSB/EiJ f 19.0 8.3516   3 4.8218 0.4396 10.0, 26.5 -1.29
WSB/EiJ m 36.186 20.824   7 7.8706 0.5755 19.0, 80.5 -0.7


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
A/J f 85.9 12.0357525478 109.5861627297 62.2138372703
A/J m 101.345875 14.1131708579 129.1203627392 73.5713872608
C57BL/6J f 90.3461538462 11.0712820928 112.1342546096 68.5580530827
C57BL/6J m 66.2307692308 11.0712820928 88.0188699942 44.4426684673
CAST/EiJ f 79.04 17.8519059673 114.1722568402 43.9077431598
CAST/EiJ m 50.2 19.9590376354 89.4790572488 10.9209427512
CC001/UncJ f 162.1666666667 23.0467115031 207.5222152189 116.8111181144
CC001/UncJ m 111.875 19.9590376354 151.1540572488 72.5959427512
CC002/UncJ f 105.5 23.0467115031 150.8555485522 60.1444514478
CC002/UncJ m 95.25 28.2263417159 150.7989754785 39.7010245215
CC003/UncJ f 51.75 28.2263417159 107.2989754785 -3.7989754785
CC003/UncJ m 29.575 19.9590376354 68.8540572488 -9.7040572488
CC004/TauUncJ f 83.4090909091 12.0357525478 107.0952536388 59.7229281794
CC004/TauUncJ m 94.6318181818 8.5105622433 111.3804644683 77.8831718954
CC005/TauUncJ f 76.75 19.9590376354 116.0290572488 37.4709427512
CC005/TauUncJ m 105.9666666667 23.0467115031 151.3222152189 60.6111181144
CC006/TauUncJ f 54.25 28.2263417159 109.7989754785 -1.2989754785
CC006/TauUncJ m 84.75 28.2263417159 140.2989754785 29.2010245215
CC007/UncJ f 62.25 28.2263417159 117.7989754785 6.7010245215
CC007/UncJ m 59.1 23.0467115031 104.4555485522 13.7444514478
CC008/GeniUncJ f 19.25 28.2263417159 74.7989754785 -36.2989754785
CC008/GeniUncJ m 34.5 28.2263417159 90.0489754785 -21.0489754785
CC009/UncJ f 46.0 23.0467115031 91.3555485522 0.6444514478
CC009/UncJ m 29.9 23.0467115031 75.2555485522 -15.4555485522
CC011/UncJ f 61.2 17.8519059673 96.3322568402 26.0677431598
CC011/UncJ m 82.1 17.8519059673 117.2322568402 46.9677431598
CC012/GeniUncJ f 110.25 28.2263417159 165.7989754785 54.7010245215
CC012/GeniUncJ m 38.0333333333 23.0467115031 83.3888818856 -7.3222152189
CC013/GeniUncJ f 99.1666666667 23.0467115031 144.5222152189 53.8111181144
CC013/GeniUncJ m 37.8333333333 23.0467115031 83.1888818856 -7.5222152189
CC016/GeniUncJ f 133.9 28.2263417159 189.4489754785 78.3510245215
CC016/GeniUncJ m 80.25 28.2263417159 135.7989754785 24.7010245215
CC017/UncJ f 97.3333333333 23.0467115031 142.6888818856 51.9777847811
CC017/UncJ m 37.375 19.9590376354 76.6540572488 -1.9040572488
CC018/UncJ f 145.6666666667 23.0467115031 191.0222152189 100.3111181144
CC018/UncJ m 74.2 17.8519059673 109.3322568402 39.0677431598
CC019/TauUncJ f 95.8 17.8519059673 130.9322568402 60.6677431598
CC019/TauUncJ m 92.3333333333 23.0467115031 137.6888818856 46.9777847811
CC023/GeniUncJ f 21.5 19.9590376354 60.7790572488 -17.7790572488
CC023/GeniUncJ m 72.2333333333 23.0467115031 117.5888818856 26.8777847811
CC024/GeniUncJ f 74.75 28.2263417159 130.2989754785 19.2010245215
CC024/GeniUncJ m 30.9 28.2263417159 86.4489754785 -24.6489754785
CC025/GeniUncJ f 55.7 28.2263417159 111.2489754785 0.1510245215
CC025/GeniUncJ m 49.25 28.2263417159 104.7989754785 -6.2989754785
CC026/GeniUncJ f 34.4 17.8519059673 69.5322568402 -0.7322568402
CC026/GeniUncJ m 30.0 23.0467115031 75.3555485522 -15.3555485522
CC027/GeniUncJ f 73.5 19.9590376354 112.7790572488 34.2209427512
CC027/GeniUncJ m 83.38 17.8519059673 118.5122568402 48.2477431598
CC028/GeniUncJ f 55.96 17.8519059673 91.0922568402 20.8277431598
CC028/GeniUncJ m 56.0 16.2964859879 88.0712159457 23.9287840543
CC030/GeniUncJ f 78.25 28.2263417159 133.7989754785 22.7010245215
CC030/GeniUncJ m 84.25 28.2263417159 139.7989754785 28.7010245215
CC032/GeniUncJ f 80.1666666667 23.0467115031 125.5222152189 34.8111181144
CC032/GeniUncJ m 26.875 19.9590376354 66.1540572488 -12.4040572488
CC035/UncJ f 57.5666666667 23.0467115031 102.9222152189 12.2111181144
CC035/UncJ m 42.45 28.2263417159 97.9989754785 -13.0989754785
CC036/UncJ f 68.8333333333 23.0467115031 114.1888818856 23.4777847811
CC036/UncJ m 37.25 28.2263417159 92.7989754785 -18.2989754785
CC040/TauUncJ f 54.25 28.2263417159 109.7989754785 -1.2989754785
CC040/TauUncJ m 101.15 28.2263417159 156.6989754785 45.6010245215
CC041/TauUncJ f 6.166666 17.8519059673 41.2989228402 -28.9655908402
CC041/TauUncJ m 5.725 11.5233557516 28.4027742761 -16.9527742761
CC044/UncJ f 10.25 28.2263417159 65.7989754785 -45.2989754785
CC044/UncJ m 3.5 28.2263417159 59.0489754785 -52.0489754785
CC051/TauUncJ f 68.75 28.2263417159 124.2989754785 13.2010245215
CC051/TauUncJ m 58.8333333333 23.0467115031 104.1888818856 13.4777847811
CC057/UncJ f 56.5 28.2263417159 112.0489754785 0.9510245215
CC057/UncJ m 25.0 28.2263417159 80.5489754785 -30.5489754785
CC059/TauUncJ f 109.25 19.9590376354 148.5290572488 69.9709427512
CC059/TauUncJ m 91.0 23.0467115031 136.3555485522 45.6444514478
CC061/GeniUncJ f 70.5 28.2263417159 126.0489754785 14.9510245215
CC061/GeniUncJ m 149.25 28.2263417159 204.7989754785 93.7010245215
CC068/TauUncJ f 14.35 19.9590376354 53.6290572488 -24.9290572488
CC068/TauUncJ m 0.6 28.2263417159 56.1489754785 -54.9489754785
CC078/TauUncJ f 100.75 28.2263417159 156.2989754785 45.2010245215
CC078/TauUncJ m 92.5 23.0467115031 137.8555485522 47.1444514478
CC079/TauUncJ f 70.0 28.2263417159 125.5489754785 14.4510245215
CC079/TauUncJ m 77.75 28.2263417159 133.2989754785 22.2010245215
CC084/TauJ f 108.9 28.2263417159 164.4489754785 53.3510245215
CC084/TauJ m 64.1666666667 23.0467115031 109.5222152189 18.8111181144
NOD/ShiLtJ f 57.2 11.0712820928 78.9881007635 35.4118992365
NOD/ShiLtJ m 58.2444444444 13.3060250903 84.4304826103 32.0584062786
NZO/HlLtJ f 74.7692307692 11.0712820928 96.5573315327 52.9811300058
NZO/HlLtJ m 74.3636363636 12.0357525478 98.0497990933 50.677473634
PWK/PhJ f 105.9090909091 12.0357525478 129.5952536388 82.2229281794
PWK/PhJ m 123.95 12.6232037666 148.7922570501 99.1077429499
WSB/EiJ f 19.0 23.0467115031 64.3555485522 -26.3555485522
WSB/EiJ m 36.1857142857 15.0876142833 65.8778906324 6.493537939


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
A/J both 93.6229375 9.2741701928 111.8743516509 75.3715233491
C57BL/6J both 78.2884615385 7.8285786443 93.6949753375 62.8819477394
CAST/EiJ both 64.62 13.3889294755 90.9691926301 38.2708073699
CC001/UncJ both 137.0208333333 15.2439667938 167.0207088449 107.0209578218
CC002/UncJ both 100.375 18.2200252317 136.2317094878 64.5182905122
CC003/UncJ both 40.6625 17.2850336273 74.6791614142 6.6458385858
CC004/TauUncJ both 89.0204545455 7.3703631032 103.5252077085 74.5157013824
CC005/TauUncJ both 91.3583333333 15.2439667938 121.3582088449 61.3584578218
CC006/TauUncJ both 69.5 19.9590376354 108.7790572488 30.2209427512
CC007/UncJ both 60.675 18.2200252317 96.5317094878 24.8182905122
CC008/GeniUncJ both 26.875 19.9590376354 66.1540572488 -12.4040572488
CC009/UncJ both 37.95 16.2964859879 70.0212159457 5.8787840543
CC011/UncJ both 71.65 12.6232037666 96.4922570501 46.8077429499
CC012/GeniUncJ both 74.1416666667 18.2200252317 109.9983761545 38.2849571788
CC013/GeniUncJ both 68.5 16.2964859879 100.5712159457 36.4287840543
CC016/GeniUncJ both 107.075 19.9590376354 146.3540572488 67.7959427512
CC017/UncJ both 67.3541666667 15.2439667938 97.3540421782 37.3542911551
CC018/UncJ both 109.9333333333 14.5760201853 138.6187009236 81.2479657431
CC019/TauUncJ both 94.0666666667 14.5760201853 122.7520342569 65.3812990764
CC023/GeniUncJ both 46.8666666667 15.2439667938 76.8665421782 16.8667911551
CC024/GeniUncJ both 52.825 19.9590376354 92.1040572488 13.5459427512
CC025/GeniUncJ both 52.475 19.9590376354 91.7540572488 13.1959427512
CC026/GeniUncJ both 32.2 14.5760201853 60.8853675903 3.5146324097
CC027/GeniUncJ both 78.44 13.3889294755 104.7891926301 52.0908073699
CC028/GeniUncJ both 55.98 12.0857974728 79.7646503176 32.1953496824
CC030/GeniUncJ both 81.25 19.9590376354 120.5290572488 41.9709427512
CC032/GeniUncJ both 53.5208333333 15.2439667938 83.5207088449 23.5209578218
CC035/UncJ both 50.0083333333 18.2200252317 85.8650428212 14.1516238455
CC036/UncJ both 53.0416666667 18.2200252317 88.8983761545 17.1849571788
CC040/TauUncJ both 77.7 19.9590376354 116.9790572488 38.4209427512
CC041/TauUncJ both 5.945833 10.6240090649 26.8537078131 -14.9620418131
CC044/UncJ both 6.875 19.9590376354 46.1540572488 -32.4040572488
CC051/TauUncJ both 63.7916666667 18.2200252317 99.6483761545 27.9349571788
CC057/UncJ both 40.75 19.9590376354 80.0290572488 1.4709427512
CC059/TauUncJ both 100.125 15.2439667938 130.1248755115 70.1251244885
CC061/GeniUncJ both 109.875 19.9590376354 149.1540572488 70.5959427512
CC068/TauUncJ both 7.475 17.2850336273 41.4916614142 -26.5416614142
CC078/TauUncJ both 96.625 18.2200252317 132.4817094878 60.7682905122
CC079/TauUncJ both 73.875 19.9590376354 113.1540572488 34.5959427512
CC084/TauJ both 86.5333333333 18.2200252317 122.3900428212 50.6766238455
NOD/ShiLtJ both 57.7222222222 8.6548193349 74.7547640885 40.689680356
NZO/HlLtJ both 74.5664335664 8.1766837191 90.6580124179 58.4748547149
PWK/PhJ both 114.9295454545 8.7207312297 132.0918008439 97.7672900652
WSB/EiJ both 27.5928571429 13.7730444698 54.6979817537 0.487732532




GWAS analysis not available: Strain panel must be either Inbred, HMDP, BXD, BXH, CXB, or AXB/BXA