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Project measure / variable:   CSNA03   infusions_do_0p18

ID, description, units MPD:110267   infusions_do_0p18   dose response, mean number of infusions (intravenous self administration) on last two stabilized sessions, DO   [n]  0.18 mg/kg  
cocaine study
Data set, strains CSNA03   DO population w/par   8 strains     sex: both     age:
Procedure operant conditioning chamber
Ontology mappings

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Distribution of Individual Animals with Boxplots.





  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested8 strains8 strains
Mean of the strain means81.2   n 81.35   n
Median of the strain means81.5   n 75.98   n
SD of the strain means± 27.662 ± 25.599
Coefficient of variation (CV)0.3406 0.3147
Min–max range of strain means30.2   –   117.8   n 57.83   –   141.4   n
Mean sample size per strain10.0   mice 10.5   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 126.3293 126.3293 0.058 0.81
strain 6 63315.0015 10552.5002 4.8473 0.0002
sex:strain 6 7240.9768 1206.8295 0.5544 0.7659
Residuals 143 311310.5527 2176.9969


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
Select table page:
Strain Sex Mean SD N mice SEM CV Min, Max Z score
A/J f 75.17 79.96   9 26.654 1.0638 -0.22
A/J m 76.47 64.29   7 24.299 0.8407 17.5, 187.5 -0.19
C57BL/6J f 107.8 37.833   11 11.407 0.3509 58.0, 186.5 0.96
C57BL/6J m 84.0 22.835   11 6.8851 0.2718 37.5, 113.0 0.1
CAST/EiJ f 96.47 56.43   4 28.217 0.585 36.0, 171.0 0.55
CAST/EiJ m 75.5 43.373   3 25.042 0.5745 28.0, 113.0 -0.23
J:DO f 66.19 43.448   21 9.4812 0.6564 7.2, 178.5 -0.54
J:DO m 70.26 41.192   27 7.9274 0.5863 3.6, 151.0 -0.43
NOD/ShiLtJ f 68.18 42.507   12 12.271 0.6234 11.4, 166.5 -0.47
NOD/ShiLtJ m 65.99 47.926   9 15.975 0.7263 9.8, 152.5 -0.6
NZO/HlLtJ f 87.83 50.29   12 14.516 0.5725 14.0, 213.5 0.24
NZO/HlLtJ m 79.32 35.056   11 10.57 0.442 3.5, 121.5 -0.08
PWK/PhJ f 117.8 50.67   10 16.024 0.4303 58.5, 196.0 1.32
PWK/PhJ m 141.4 46.161   10 14.597 0.3263 63.5, 216.0 2.35
WSB/EiJ f 30.2 0.0   1   0.0 0.0 30.2, 30.2 -1.84
WSB/EiJ m 57.83 42.473   6 17.34 0.7344 30.5, 141.5 -0.92


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
A/J f 75.1666666667 15.5527663562 105.9096985793 44.4236347541
A/J m 76.4714285714 17.635179419 111.3307501381 41.6121070048
C57BL/6J f 107.8181818182 14.0680064879 135.6263004833 80.0100631531
C57BL/6J m 84.0 14.0680064879 111.8081186651 56.1918813349
CAST/EiJ f 96.475 23.3291495344 142.5895478689 50.3604521311
CAST/EiJ m 75.5 26.9381815273 128.7484932514 22.2515067486
J:DO f 66.1880952381 10.1816755848 86.3141339284 46.0620565478
J:DO m 70.2592592593 8.9793938424 88.0087570097 52.5097615088
NOD/ShiLtJ f 68.1833333333 13.4690907636 94.807579959 41.5590867077
NOD/ShiLtJ m 65.9888888889 15.5527663562 96.7319208015 35.2458569763
NZO/HlLtJ f 87.8333333333 13.4690907636 114.457579959 61.2090867077
NZO/HlLtJ m 79.3181818182 14.0680064879 107.1263004833 51.5100631531
PWK/PhJ f 117.775 14.7546496807 146.9404009069 88.6095990931
PWK/PhJ m 141.45 14.7546496807 170.6154009069 112.2845990931


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
A/J both 75.819047619 11.7567862793 99.0585953302 52.5794999079
C57BL/6J both 95.9090909091 9.9475827854 115.5724001892 76.245781629
CAST/EiJ both 85.9875 17.8179322734 121.208067708 50.766932292
J:DO both 68.2236772487 6.7877837232 81.6410363755 54.8063181218
NOD/ShiLtJ both 67.0861111111 10.2871879944 87.4207153583 46.7515068639
NZO/HlLtJ both 83.5757575758 9.738136533 102.825056083 64.3264590686
PWK/PhJ both 129.6125 10.4331128432 150.2355527573 108.9894472427




GWAS analysis not available: Strain panel must be either Inbred, HMDP, BXD, BXH, CXB, or AXB/BXA