Project measure / variable:   CSNA03   infusions_do_1p0

ID, description, units MPD:110262   infusions_do_1p0   dose response, mean number of infusions (intravenous self administration) on last two stabilized sessions, DO   [n]  1.0 mg/kg  
cocaine study
Data set, strains CSNA03   DO population w/par   9 strains     sex: both     age:
Procedure operant conditioning chamber
Ontology mappings

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Plot Options Bins number: (min: 10, max: 40)


Distribution of Individual Animals with Boxplots.





  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested9 strains9 strains
Mean of the strain means22.342   n 24.388   n
Median of the strain means20.995   n 26.192   n
SD of the strain means± 14.811 ± 15.455
Coefficient of variation (CV)0.6629 0.6337
Min–max range of strain means0.0   –   50.83   n 0.0   –   46.646   n
Mean sample size per strain74.7   mice 71.2   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 1665.4539 1665.4539 4.8366 0.028
strain 8 52250.4503 6531.3063 18.9674 < 0.0001
sex:strain 8 2358.0187 294.7523 0.856 0.5534
Residuals 1295 445924.3226 344.3431


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
Select table page:
Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ f 0.0 0.0   12 0.0 None -1.51
129S1/SvImJ m 0.0 0.0   12 0.0 None -1.58
A/J f 26.673 24.08   15 6.2175 0.9028 0.29
A/J m 30.416 20.301   11 6.1208 0.6674 0.39
C57BL/6J f 18.49 16.371   24 3.3417 0.8854 -0.26
C57BL/6J m 16.898 13.939   21 3.0416 0.8249 -0.48
CAST/EiJ f 33.474 30.643   10 9.6901 0.9154 4.0, 102.5 0.75
CAST/EiJ m 46.646 25.16   8 8.8954 0.5394 17.5, 96.0 1.44
J:DO f 19.6 19.664   546 0.84152 1.0033 -0.19
J:DO m 16.911 17.82   537 0.769 1.0537 -0.48
NOD/ShiLtJ f 25.1 13.891   15 3.5867 0.5534 0.19
NOD/ShiLtJ m 26.192 13.963   10 4.4154 0.5331 1.9167, 49.5 0.12
NZO/HlLtJ f 20.995 6.6902   14 1.788 0.3187 4.4286, 34.0 -0.09
NZO/HlLtJ m 28.5 10.927   11 3.2946 0.3834 20.0, 59.0 0.27
PWK/PhJ f 50.83 30.668   18 7.2286 0.6033 12.0, 115.5 1.92
PWK/PhJ m 44.836 21.913   14 5.8564 0.4887 25.5, 100.0 1.32
WSB/EiJ f 5.9188 3.9541   18 0.93198 0.6681 -1.11
WSB/EiJ m 9.0892 8.2222   17 1.9942 0.9046 -0.99


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ f 0.0 5.3567955774 10.5089483776 -10.5089483776
129S1/SvImJ m 0.0 5.3567955774 10.5089483776 -10.5089483776
A/J f 26.6732333333 4.791263621 36.072722511 17.2737441556
A/J m 30.4160909091 5.5949905053 41.3923295099 19.4398523083
C57BL/6J f 18.4898320833 3.7878264782 25.9207807443 11.0588834224
C57BL/6J m 16.898047619 4.0493568348 24.8420658899 8.9540293482
CAST/EiJ f 33.47381 5.8680755473 44.9857861641 21.9618338359
CAST/EiJ m 46.645875 6.5607079105 59.5166556291 33.7750943709
J:DO f 19.5996891758 0.7941442122 21.1576393366 18.0417390151
J:DO m 16.9113577095 0.8007713998 18.4823090706 15.3404063484
NOD/ShiLtJ f 25.1 4.791263621 34.4994891777 15.7005108223
NOD/ShiLtJ m 26.19167 5.8680755473 37.7036461641 14.6796938359
NZO/HlLtJ f 20.9949 4.9594290159 30.7242956354 11.2655043646
NZO/HlLtJ m 28.5 5.5949905053 39.4762386008 17.5237613992
PWK/PhJ f 50.8325 4.3738052737 59.4130204194 42.2519795806
PWK/PhJ m 44.8357142857 4.9594290159 54.5651099211 35.1063186503
WSB/EiJ f 5.9188 4.3738052737 14.4993204194 -2.6617204194
WSB/EiJ m 9.0891588235 4.5006084967 17.9184414938 0.2598761532


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ both 0.0 3.7878264782 7.4309486609 -7.4309486609
A/J both 28.5446621212 3.683073643 35.770106928 21.3192173144
C57BL/6J both 17.6939398512 2.7724051023 23.1328373564 12.255042346
CAST/EiJ both 40.0598425 4.4010566605 48.6938246231 31.4258603769
J:DO both 18.2555234427 0.5638926903 19.3617667344 17.1492801509
NOD/ShiLtJ both 25.645835 3.7878264782 33.0767836609 18.2148863391
NZO/HlLtJ both 24.74745 3.7383102773 32.0812578999 17.4136421001
PWK/PhJ both 47.8341071429 3.3062860106 54.3203708998 41.3478433859
WSB/EiJ both 7.5039794118 3.1378993536 13.6599026395 1.3480561841




GWAS analysis not available: Strain panel must be either Inbred, HMDP, BXD, BXH, CXB, or AXB/BXA