Project measure / variable:   CSNA03   reinstatement_active_in_s2

ID, description, units MPD:110217   reinstatement_active_in_s2   reinstatement, active lever presses (intravenous self administration), founders   [n]  session 2  
cocaine study
Data set, strains CSNA03   inbred w/CC8   7 strains     sex: both     age:
Procedure operant conditioning chamber
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  STRAIN COMPARISON PLOT
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CSNA03 - reinstatement, active lever presses (intravenous self administration), founders session 2



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested7 strains7 strains
Mean of the strain means114.4   n 73.38   n
Median of the strain means103.7   n 68.4   n
SD of the strain means± 53.74 ± 20.9
Coefficient of variation (CV)0.47 0.2848
Min–max range of strain means51.9   –   202.3   n 53.0   –   117.8   n
Mean sample size per strain7.6   mice 7.0   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 33935.4965 33935.4965 4.6125 0.0345
strain 5 116314.9771 23262.9954 3.1619 0.0114
sex:strain 5 64550.724 12910.1448 1.7547 0.1307
Residuals 87 640088.8832 7357.3435


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
A/J f 64.44 65.34   9 21.781 1.0139 1.0, 210.0 -0.93
A/J m 61.43 51.61   7 19.506 0.8401 -0.57
C57BL/6J f 202.3 145.8   12 42.093 0.7207 19.0, 500.0 1.64
C57BL/6J m 76.23 60.46   13 16.768 0.7931 5.0, 229.0 0.14
CAST/EiJ f 160.0 0.0   1   0.0 0.0 160.0, 160.0 0.85
CAST/EiJ m 66.5 72.83   2   51.5 1.0952 15.0, 118.0 -0.33
NOD/ShiLtJ f 87.27 141.3   11 42.595 1.6187 2.0, 482.0 -0.5
NOD/ShiLtJ m 70.33 50.31   6 20.537 0.7152 12.0, 136.0 -0.15
NZO/HlLtJ f 51.9 39.267   10 12.417 0.7566 -1.16
NZO/HlLtJ m 53.0 29.518   10 9.3345 0.557 9.0, 118.0 -0.98
PWK/PhJ f 130.9 77.99   7 29.479 0.596 60.0, 261.0 0.31
PWK/PhJ m 117.8 65.55   6 26.761 0.5563 32.0, 230.0 2.13
WSB/EiJ f 103.7 83.77   3 48.364 0.8081 7.0, 155.0 -0.2
WSB/EiJ m 68.4 39.488   5 17.66 0.5773 16.0, 113.0 -0.24


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
A/J f 64.4444444444 28.5916527924 121.2734503189 7.6154385699
A/J m 61.4285714286 32.4198869404 125.8666071996 -3.0094643424
C57BL/6J f 202.3333333333 24.7610976544 251.5486960925 153.1179705742
C57BL/6J m 76.2307692308 23.7896931215 123.5153602956 28.946178166
NOD/ShiLtJ f 87.2727272727 25.8621230314 138.6764971894 35.868957356
NOD/ShiLtJ m 70.3333333333 35.0174801221 139.9343668244 0.7322998423
NZO/HlLtJ f 51.9 27.1244234678 105.812728718 -2.012728718
NZO/HlLtJ m 53.0 27.1244234678 106.912728718 -0.912728718
PWK/PhJ f 130.8571428571 32.4198869404 195.2951786281 66.4191070862
PWK/PhJ m 117.8333333333 35.0174801221 187.4343668244 48.2322998423
WSB/EiJ f 103.6666666667 49.5221953088 202.0973921849 5.2359411484
WSB/EiJ m 68.4 38.3597275397 144.6441121375 -7.8441121375


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
A/J both 62.9365079365 21.6132579603 105.8951984505 19.9778174225
C57BL/6J both 139.2820512821 17.1687321596 173.4067655068 105.1573370573
NOD/ShiLtJ both 78.803030303 21.7662199394 122.0657493134 35.5403112927
NZO/HlLtJ both 52.45 19.1798637699 90.5720560687 14.3279439313
PWK/PhJ both 124.3452380952 23.8603907309 171.770348314 76.9201278765
WSB/EiJ both 86.0333333333 31.3205863815 148.2863902094 23.7802764572




  GWAS USING LINEAR MIXED MODELS