Project measure / variable:   CSNA03   extinction_active_in_s4

ID, description, units MPD:110201   extinction_active_in_s4   extinction, active lever presses (intravenous self administration), founders   [n]  session 4  
cocaine study
Data set, strains CSNA03   inbred w/CC8   7 strains     sex: both     age:
Procedure operant conditioning chamber
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  STRAIN COMPARISON PLOT
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CSNA03 - extinction, active lever presses (intravenous self administration), founders session 4



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested7 strains7 strains
Mean of the strain means64.7   n 42.012   n
Median of the strain means64.86   n 28.4   n
SD of the strain means± 35.731 ± 22.723
Coefficient of variation (CV)0.5523 0.5409
Min–max range of strain means15.333   –   110.1   n 22.5   –   76.71   n
Mean sample size per strain7.1   mice 6.7   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 17150.494 17150.494 3.0626 0.0839
strain 5 71046.4467 14209.2893 2.5374 0.0347
sex:strain 5 17029.0244 3405.8049 0.6082 0.6938
Residuals 82 459201.737 5600.0212


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
A/J f 15.333 9.7502   6 3.9805 0.6359 6.0, 31.0 -1.38
A/J m 24.714 40.269   7 15.22 1.6294 -0.76
C57BL/6J f 110.1 88.96   12 25.682 0.8082 1.27
C57BL/6J m 52.36 65.95   11 19.885 1.2595 10.0, 241.0 0.46
CAST/EiJ f 72.0 0.0   1   0.0 0.0 72.0, 72.0 0.2
CAST/EiJ m 22.5 2.1213   2   1.5 0.0943 21.0, 24.0 -0.86
NOD/ShiLtJ f 106.5 161.4   11 48.658 1.516 3.0, 453.0 1.17
NOD/ShiLtJ m 66.0 47.418   5 21.206 0.7185 19.0, 144.0 1.06
NZO/HlLtJ f 29.1 20.915   10 6.6139 0.7187 -1.0
NZO/HlLtJ m 23.4 24.19   10 7.6495 1.0338 2.0, 83.0 -0.82
PWK/PhJ f 64.86 43.857   7 16.577 0.6762 29.0, 134.0 0.0
PWK/PhJ m 76.71 54.35   7 20.541 0.7084 7.0, 145.0 1.53
WSB/EiJ f 55.0 59.57   3 34.395 1.0832 12.0, 123.0 -0.27
WSB/EiJ m 28.4 29.348   5 13.125 1.0334 7.0, 73.0 -0.6


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
A/J f 15.3333333333 30.5505624146 76.1081340756 -45.441467409
A/J m 24.7142857143 28.2843247428 80.9808178012 -31.5522463726
C57BL/6J f 110.0833333333 21.6025098524 153.0576070635 67.1090596032
C57BL/6J m 52.3636363636 22.5630856672 97.2488013877 7.4784713396
NOD/ShiLtJ f 106.4545454545 22.5630856672 151.3397104786 61.5693804305
NOD/ShiLtJ m 66.0 33.4664643579 132.5754585889 -0.5754585889
NZO/HlLtJ f 29.1 23.6643638898 76.1759582288 -17.9759582288
NZO/HlLtJ m 23.4 23.6643638898 70.4759582288 -23.6759582288
PWK/PhJ f 64.8571428571 28.2843247428 121.123674944 8.5906107703
PWK/PhJ m 76.7142857143 28.2843247428 132.9808178012 20.4477536274
WSB/EiJ f 55.0 43.2050197048 140.9485474603 -30.9485474603
WSB/EiJ m 28.4 33.4664643579 94.9754585889 -38.1754585889


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
A/J both 20.0238095238 20.8166993661 61.4348558712 -21.3872368236
C57BL/6J both 81.2234848485 15.6185888187 112.2938334218 50.1531362752
NOD/ShiLtJ both 86.2272727273 20.1810373336 126.3737847973 46.0807606572
NZO/HlLtJ both 26.25 16.7332321789 59.5377292944 -7.0377292944
PWK/PhJ both 70.7857142857 20.0000378269 110.5721606782 30.9992678932
WSB/EiJ both 41.7 27.3252537239 96.0586343115 -12.6586343115




  GWAS USING LINEAR MIXED MODELS