ITP survival analysis:   resveratrol

Intervention:   resveratrol     dietary supplement
Trial code: Res Dose: 300 ppm initiated at age: 4 mo Sex: both Cohort: C2007
Results are based on the use of pooled factor(s) that is/are stratified within the survival analysis model.

All test sites combined – female
Res effect on survival, females, test site = All
Log-rank test chisq = 0.0259 p = 0.8722
Wang-Allison test odds ratio = 0.5727 p = 0.1623
Quantiles Res Control % difference
25% died before day: 807 753 +7 %
Median lifespan (days) 903 865 +4 %
75% died before day: 980 994 -1 %
90% died before day: 1086 1088 0 %
Max lifespan observed (days) 1374 1359
Number of mice at start 129 275
Animal censor events are denoted by + marks in the plot
All test sites combined – male
Res effect on survival, males, test site = All
Log-rank test chisq = 0.0017 p = 0.9674
Wang-Allison test odds ratio = 0.719 p = 0.3999
Quantiles Res Control % difference
25% died before day: 616 588 +5 %
Median lifespan (days) 812 784 +4 %
75% died before day: 968 954 +1 %
90% died before day: 1060 1074 -1 %
Max lifespan observed (days) 1186 1247
Number of mice at start 144 276
Animal censor events are denoted by + marks in the plot


By individual test site:

TJL – female
TJL – female      
Res effect on survival, females, test site = TJL
Log-rank test chisq = 0.5994 p = 0.4388
Wang-Allison test odds ratio = 0.9349 p = 1.0
Quantiles Res Control % difference
25% died before day: 814 740 +10 %
Median lifespan (days) 938 860 +9 %
75% died before day: 998 1016 -2 %
90% died before day: 1111 1111 0 %
Max lifespan observed (days) 1374 1340
Number of mice at start 44 92
Animal censor events are denoted by + marks in the plot
TJL – male
TJL – male      
Res effect on survival, males, test site = TJL
Log-rank test chisq = 0.4058 p = 0.5241
Wang-Allison test odds ratio = 1.3139 p = 0.7713
Quantiles Res Control % difference
25% died before day: 636 569 +12 %
Median lifespan (days) 754 728 +4 %
75% died before day: 941 923 +2 %
90% died before day: 1057 1039 +2 %
Max lifespan observed (days) 1177 1200
Number of mice at start 51 87
Animal censor events are denoted by + marks in the plot
UM – female
UM – female      
Res effect on survival, females, test site = UM
Log-rank test chisq = 0.4069 p = 0.5235
Wang-Allison test odds ratio = 0.5617 p = 0.5471
Quantiles Res Control % difference
25% died before day: 853 767 +11 %
Median lifespan (days) 930 900 +3 %
75% died before day: 1003 999 0 %
90% died before day: 1101 1114 -1 %
Max lifespan observed (days) 1133 1359
Number of mice at start 42 91
Animal censor events are denoted by + marks in the plot
UM – male
UM – male      
Res effect on survival, males, test site = UM
Log-rank test chisq = 0.8512 p = 0.3562
Wang-Allison test odds ratio = 1.2425 p = 0.7776
Quantiles Res Control % difference
25% died before day: 691 659 +5 %
Median lifespan (days) 869 793 +10 %
75% died before day: 1017 953 +7 %
90% died before day: 1102 1076 +2 %
Max lifespan observed (days) 1186 1191
Number of mice at start 51 93
Animal censor events are denoted by + marks in the plot
UT – female
UT – female      
Res effect on survival, females, test site = UT
Log-rank test chisq = 1.4842 p = 0.2231
Wang-Allison test odds ratio = 0.3274 p = 0.2245
Quantiles Res Control % difference
25% died before day: 696 756 -8 %
Median lifespan (days) 833 840 -1 %
75% died before day: 945 962 -2 %
90% died before day: 984 1045 -6 %
Max lifespan observed (days) 1104 1261
Number of mice at start 43 92
Animal censor events are denoted by + marks in the plot
UT – male
UT – male      
Res effect on survival, males, test site = UT
Log-rank test chisq = 3.0817 p = 0.0792
Wang-Allison test odds ratio = 0.0 p = 0.0056
Quantiles Res Control % difference
25% died before day: 561 584 -4 %
Median lifespan (days) 821 810 +1 %
75% died before day: 942 1010 -7 %
90% died before day: 995 1132 -12 %
Max lifespan observed (days) 1060 1247
Number of mice at start 42 96
Animal censor events are denoted by + marks in the plot


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Statistical definitions