ITP survival analysis:   rapamycin

Intervention:   rapamycin     mTOR complex repressor, anti-aging
Trial code: Rapa_hi_start_stop Dose: 42 ppm initiated at age: 20 mo (stop at 23) Sex: both Cohort: C2015
Trial code: Rapa_hi_cycle Dose: 42 ppm initiated at age: 20 mo (but every other month) Sex: both Cohort: C2015
Trial code: Rapa_hi_continuous Dose: 42 ppm initiated at age: 20 mo Sex: both Cohort: C2015
This compound had a significant effect on survival:   males p = 0.0243

This compound had a significant effect on survival:   females = 0.0001; males p = 0.0019

This compound had a significant effect on survival:   females p < 0.0001; males p = 0.0007

Results are based on the use of pooled factor(s) that is/are stratified within the survival analysis model.

All test sites combined – female
Rapa_hi_start_stop effect on survival, females, test site = All
Log-rank test chisq = 2.0984 p = 0.1475
Wang-Allison test odds ratio = 1.608 p = 0.1664
Quantiles Rapa_hi_start_stop Control % difference
25% died before day: 808 786 +3 %
Median lifespan (days) 940 904 +4 %
75% died before day: 1052 1016 +4 %
90% died before day: 1136 1095 +4 %
Max lifespan observed (days) 1274 1396
Number of mice at start 134 274
Animal censor events are denoted by + marks in the plot
Rapa_hi_cycle effect on survival, females, test site = All
Log-rank test chisq = 15.7906 p < 0.0001
Wang-Allison test odds ratio = 3.7741 p < 0.0001
Quantiles Rapa_hi_cycle Control % difference
25% died before day: 825 786 +5 %
Median lifespan (days) 977 904 +8 %
75% died before day: 1117 1016 +10 %
90% died before day: 1203 1095 +10 %
Max lifespan observed (days) 1332 1396
Number of mice at start 133 274
Animal censor events are denoted by + marks in the plot
Rapa_hi_continuous effect on survival, females, test site = All
Log-rank test chisq = 32.7164 p < 0.0001
Wang-Allison test odds ratio = 9.7514 p < 0.0001
Quantiles Rapa_hi_continuous Control % difference
25% died before day: 790 786 +1 %
Median lifespan (days) 1040 904 +15 %
75% died before day: 1174 1016 +16 %
90% died before day: 1231 1095 +12 %
Max lifespan observed (days) 1344 1396
Number of mice at start 136 274
Animal censor events are denoted by + marks in the plot
All test sites combined – male
Rapa_hi_start_stop effect on survival, males, test site = All
Log-rank test chisq = 5.0707 p = 0.0243
Wang-Allison test odds ratio = 1.6173 p = 0.158
Quantiles Rapa_hi_start_stop Control % difference
25% died before day: 608 581 +5 %
Median lifespan (days) 854 772 +11 %
75% died before day: 1020 918 +11 %
90% died before day: 1100 1049 +5 %
Max lifespan observed (days) 1264 1237
Number of mice at start 127 264
Animal censor events are denoted by + marks in the plot
Rapa_hi_cycle effect on survival, males, test site = All
Log-rank test chisq = 9.6323 p = 0.0019
Wang-Allison test odds ratio = 2.1132 p = 0.0251
Quantiles Rapa_hi_cycle Control % difference
25% died before day: 584 581 +1 %
Median lifespan (days) 841 772 +9 %
75% died before day: 1056 918 +15 %
90% died before day: 1144 1049 +9 %
Max lifespan observed (days) 1348 1237
Number of mice at start 144 264
Animal censor events are denoted by + marks in the plot
Rapa_hi_continuous effect on survival, males, test site = All
Log-rank test chisq = 11.6084 p = 0.0007
Wang-Allison test odds ratio = 2.4057 p = 0.01
Quantiles Rapa_hi_continuous Control % difference
25% died before day: 652 581 +12 %
Median lifespan (days) 856 772 +11 %
75% died before day: 1006 918 +10 %
90% died before day: 1148 1049 +9 %
Max lifespan observed (days) 1358 1237
Number of mice at start 146 264
Animal censor events are denoted by + marks in the plot


By individual test site:

TJL – female
TJL – female      
Rapa_hi_start_stop effect on survival, females, test site = TJL
Log-rank test chisq = 0.6533 p = 0.4189
Wang-Allison test odds ratio = 1.1506 p = 0.7734
Quantiles Rapa_hi_start_stop Control % difference
25% died before day: 879 785 +12 %
Median lifespan (days) 986 928 +6 %
75% died before day: 1067 1043 +2 %
90% died before day: 1169 1156 +1 %
Max lifespan observed (days) 1274 1396
Number of mice at start 46 95
Animal censor events are denoted by + marks in the plot
Rapa_hi_cycle effect on survival, females, test site = TJL
Log-rank test chisq = 6.8447 p = 0.0089
Wang-Allison test odds ratio = 3.0603 p = 0.0681
Quantiles Rapa_hi_cycle Control % difference
25% died before day: 875 785 +11 %
Median lifespan (days) 1074 928 +16 %
75% died before day: 1138 1043 +9 %
90% died before day: 1226 1156 +6 %
Max lifespan observed (days) 1266 1396
Number of mice at start 46 95
Animal censor events are denoted by + marks in the plot
Rapa_hi_continuous effect on survival, females, test site = TJL
Log-rank test chisq = 11.6026 p = 0.0007
Wang-Allison test odds ratio = 6.6618 p = 0.0011
Quantiles Rapa_hi_continuous Control % difference
25% died before day: 882 785 +12 %
Median lifespan (days) 1108 928 +19 %
75% died before day: 1202 1043 +15 %
90% died before day: 1275 1156 +10 %
Max lifespan observed (days) 1329 1396
Number of mice at start 48 95
Animal censor events are denoted by + marks in the plot
TJL – male
TJL – male      
Rapa_hi_start_stop effect on survival, males, test site = TJL
Log-rank test chisq = 0.0666 p = 0.7963
Wang-Allison test odds ratio = 0.8013 p = 1.0
Quantiles Rapa_hi_start_stop Control % difference
25% died before day: 606 608 0 %
Median lifespan (days) 729 818 -11 %
75% died before day: 922 942 -2 %
90% died before day: 1029 1061 -3 %
Max lifespan observed (days) 1243 1237
Number of mice at start 45 92
Animal censor events are denoted by + marks in the plot
Rapa_hi_cycle effect on survival, males, test site = TJL
Log-rank test chisq = 3.2273 p = 0.0724
Wang-Allison test odds ratio = 2.2454 p = 0.1581
Quantiles Rapa_hi_cycle Control % difference
25% died before day: 652 608 +7 %
Median lifespan (days) 826 818 +1 %
75% died before day: 1036 942 +10 %
90% died before day: 1173 1061 +11 %
Max lifespan observed (days) 1348 1237
Number of mice at start 51 92
Animal censor events are denoted by + marks in the plot
Rapa_hi_continuous effect on survival, males, test site = TJL
Log-rank test chisq = 0.8418 p = 0.3589
Wang-Allison test odds ratio = 1.6642 p = 0.398
Quantiles Rapa_hi_continuous Control % difference
25% died before day: 617 608 +1 %
Median lifespan (days) 817 818 0 %
75% died before day: 969 942 +3 %
90% died before day: 1138 1061 +7 %
Max lifespan observed (days) 1248 1237
Number of mice at start 51 92
Animal censor events are denoted by + marks in the plot
UM – female
UM – female      
Rapa_hi_start_stop effect on survival, females, test site = UM
Log-rank test chisq = 0.4948 p = 0.4818
Wang-Allison test odds ratio = 2.2552 p = 0.2262
Quantiles Rapa_hi_start_stop Control % difference
25% died before day: 780 791 -1 %
Median lifespan (days) 904 899 +1 %
75% died before day: 1036 992 +4 %
90% died before day: 1123 1079 +4 %
Max lifespan observed (days) 1249 1291
Number of mice at start 44 91
Animal censor events are denoted by + marks in the plot
Rapa_hi_cycle effect on survival, females, test site = UM
Log-rank test chisq = 4.7597 p = 0.0291
Wang-Allison test odds ratio = 4.3675 p = 0.0135
Quantiles Rapa_hi_cycle Control % difference
25% died before day: 812 791 +3 %
Median lifespan (days) 937 899 +4 %
75% died before day: 1082 992 +9 %
90% died before day: 1184 1079 +10 %
Max lifespan observed (days) 1311 1291
Number of mice at start 44 91
Animal censor events are denoted by + marks in the plot
Rapa_hi_continuous effect on survival, females, test site = UM
Log-rank test chisq = 5.1415 p = 0.0234
Wang-Allison test odds ratio = 9.589 p = 0.0003
Quantiles Rapa_hi_continuous Control % difference
25% died before day: 680 791 -14 %
Median lifespan (days) 920 899 +2 %
75% died before day: 1172 992 +18 %
90% died before day: 1189 1079 +10 %
Max lifespan observed (days) 1252 1291
Number of mice at start 44 91
Animal censor events are denoted by + marks in the plot
UM – male
UM – male      
Rapa_hi_start_stop effect on survival, males, test site = UM
Log-rank test chisq = 2.195 p = 0.1385
Wang-Allison test odds ratio = 2.6526 p = 0.1771
Quantiles Rapa_hi_start_stop Control % difference
25% died before day: 596 601 -1 %
Median lifespan (days) 837 740 +13 %
75% died before day: 1025 905 +13 %
90% died before day: 1107 1027 +8 %
Max lifespan observed (days) 1162 1231
Number of mice at start 34 81
Animal censor events are denoted by + marks in the plot
Rapa_hi_cycle effect on survival, males, test site = UM
Log-rank test chisq = 13.9215 p = 0.0002
Wang-Allison test odds ratio = 4.3422 p = 0.023
Quantiles Rapa_hi_cycle Control % difference
25% died before day: 745 601 +24 %
Median lifespan (days) 1044 740 +41 %
75% died before day: 1126 905 +24 %
90% died before day: 1156 1027 +13 %
Max lifespan observed (days) 1256 1231
Number of mice at start 45 81
Animal censor events are denoted by + marks in the plot
Rapa_hi_continuous effect on survival, males, test site = UM
Log-rank test chisq = 2.439 p = 0.1183
Wang-Allison test odds ratio = 3.0121 p = 0.0716
Quantiles Rapa_hi_continuous Control % difference
25% died before day: 721 601 +20 %
Median lifespan (days) 828 740 +12 %
75% died before day: 982 905 +9 %
90% died before day: 1078 1027 +5 %
Max lifespan observed (days) 1162 1231
Number of mice at start 48 81
Animal censor events are denoted by + marks in the plot
UT – female
UT – female      
Rapa_hi_start_stop effect on survival, females, test site = UT
Log-rank test chisq = 0.9968 p = 0.3181
Wang-Allison test odds ratio = 1.5732 p = 0.5496
Quantiles Rapa_hi_start_stop Control % difference
25% died before day: 792 786 +1 %
Median lifespan (days) 940 892 +5 %
75% died before day: 1038 1014 +2 %
90% died before day: 1097 1078 +2 %
Max lifespan observed (days) 1229 1280
Number of mice at start 44 88
Animal censor events are denoted by + marks in the plot
Rapa_hi_cycle effect on survival, females, test site = UT
Log-rank test chisq = 4.2871 p = 0.0384
Wang-Allison test odds ratio = 3.9747 p = 0.025
Quantiles Rapa_hi_cycle Control % difference
25% died before day: 753 786 -4 %
Median lifespan (days) 949 892 +6 %
75% died before day: 1105 1014 +9 %
90% died before day: 1162 1078 +8 %
Max lifespan observed (days) 1332 1280
Number of mice at start 43 88
Animal censor events are denoted by + marks in the plot
Rapa_hi_continuous effect on survival, females, test site = UT
Log-rank test chisq = 17.899 p < 0.0001
Wang-Allison test odds ratio = 15.7541 p < 0.0001
Quantiles Rapa_hi_continuous Control % difference
25% died before day: 901 786 +15 %
Median lifespan (days) 1032 892 +16 %
75% died before day: 1149 1014 +13 %
90% died before day: 1192 1078 +11 %
Max lifespan observed (days) 1344 1280
Number of mice at start 44 88
Animal censor events are denoted by + marks in the plot
UT – male
UT – male      
Rapa_hi_start_stop effect on survival, males, test site = UT
Log-rank test chisq = 6.7747 p = 0.0092
Wang-Allison test odds ratio = 2.0375 p = 0.2397
Quantiles Rapa_hi_start_stop Control % difference
25% died before day: 682 500 +36 %
Median lifespan (days) 891 786 +13 %
75% died before day: 1038 888 +17 %
90% died before day: 1122 1025 +9 %
Max lifespan observed (days) 1264 1220
Number of mice at start 48 91
Animal censor events are denoted by + marks in the plot
Rapa_hi_cycle effect on survival, males, test site = UT
Log-rank test chisq = 0.0077 p = 0.9299
Wang-Allison test odds ratio = 1.059 p = 1.0
Quantiles Rapa_hi_cycle Control % difference
25% died before day: 474 500 -5 %
Median lifespan (days) 744 786 -5 %
75% died before day: 981 888 +10 %
90% died before day: 1052 1025 +3 %
Max lifespan observed (days) 1127 1220
Number of mice at start 48 91
Animal censor events are denoted by + marks in the plot
Rapa_hi_continuous effect on survival, males, test site = UT
Log-rank test chisq = 11.7865 p = 0.0006
Wang-Allison test odds ratio = 2.8813 p = 0.074
Quantiles Rapa_hi_continuous Control % difference
25% died before day: 611 500 +22 %
Median lifespan (days) 912 786 +16 %
75% died before day: 1066 888 +20 %
90% died before day: 1169 1025 +14 %
Max lifespan observed (days) 1358 1220
Number of mice at start 47 91
Animal censor events are denoted by + marks in the plot


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Statistical definitions