ITP survival analysis:   rapamycin and acarbose

Intervention:   rapamycin and acarbose    
Trial code: RaAc9 Dose: Rapa: 14.7 ppm and ACA: 1000 ppm initiated at age: 9 mo Sex: both Cohort: C2017
Trial code: RaAc16 Dose: Rapa: 14.7 ppm and ACA: 1000 ppm initiated at age: 16 mo Sex: both Cohort: C2017
This compound had a significant effect on survival:   9 mo females p < 0.0001; 9 mo males p < 0.0001; 16 mo females p < 0.0001; 16 mo males p < 0.0001

Results are based on the use of pooled factor(s) that is/are stratified within the survival analysis model.

All test sites combined – female
RaAc9 effect on survival, females, test site = All
Log-rank test chisq = 123.0856 p < 0.0001
Wang-Allison test odds ratio = 38.3698 p < 0.0001
Quantiles RaAc9 Control % difference
25% died before day: 930 767 +21 %
Median lifespan (days) 1107 868 +28 %
75% died before day: 1221 958 +27 %
90% died before day: 1278 1060 +21 %
Max lifespan observed (days) 1395 1221
Number of mice at start 134 276
Animal censor events are denoted by + marks in the plot
RaAc16 effect on survival, females, test site = All
Log-rank test chisq = 60.6499 p < 0.0001
Wang-Allison test odds ratio = 11.7611 p < 0.0001
Quantiles RaAc16 Control % difference
25% died before day: 845 767 +10 %
Median lifespan (days) 976 868 +12 %
75% died before day: 1158 958 +21 %
90% died before day: 1223 1060 +15 %
Max lifespan observed (days) 1342 1221
Number of mice at start 134 276
Animal censor events are denoted by + marks in the plot
All test sites combined – male
RaAc9 effect on survival, males, test site = All
Log-rank test chisq = 76.6987 p < 0.0001
Wang-Allison test odds ratio = 15.7968 p < 0.0001
Quantiles RaAc9 Control % difference
25% died before day: 742 447 +66 %
Median lifespan (days) 981 718 +37 %
75% died before day: 1172 919 +28 %
90% died before day: 1272 1029 +24 %
Max lifespan observed (days) 1389 1258
Number of mice at start 153 285
Animal censor events are denoted by + marks in the plot
RaAc16 effect on survival, males, test site = All
Log-rank test chisq = 20.7332 p < 0.0001
Wang-Allison test odds ratio = 3.6334 p < 0.0001
Quantiles RaAc16 Control % difference
25% died before day: 543 447 +21 %
Median lifespan (days) 815 718 +14 %
75% died before day: 1043 919 +13 %
90% died before day: 1217 1029 +18 %
Max lifespan observed (days) 1309 1258
Number of mice at start 138 285
Animal censor events are denoted by + marks in the plot


By individual test site:

TJL – female
TJL – female      
RaAc9 effect on survival, females, test site = TJL
Log-rank test chisq = 55.5438 p < 0.0001
Wang-Allison test odds ratio = NaN p < 0.0001
Quantiles RaAc9 Control % difference
25% died before day: 1016 760 +34 %
Median lifespan (days) 1146 870 +32 %
75% died before day: 1248 968 +29 %
90% died before day: 1304 1068 +22 %
Max lifespan observed (days) 1395 1209
Number of mice at start 48 96
Animal censor events are denoted by + marks in the plot
RaAc16 effect on survival, females, test site = TJL
Log-rank test chisq = 35.123 p < 0.0001
Wang-Allison test odds ratio = 17.0768 p < 0.0001
Quantiles RaAc16 Control % difference
25% died before day: 921 760 +21 %
Median lifespan (days) 1052 870 +21 %
75% died before day: 1188 968 +23 %
90% died before day: 1275 1068 +19 %
Max lifespan observed (days) 1342 1209
Number of mice at start 48 96
Animal censor events are denoted by + marks in the plot
TJL – male
TJL – male      
RaAc9 effect on survival, males, test site = TJL
Log-rank test chisq = 13.4192 p = 0.0002
Wang-Allison test odds ratio = 10.292 p < 0.0001
Quantiles RaAc9 Control % difference
25% died before day: 627 488 +28 %
Median lifespan (days) 847 748 +13 %
75% died before day: 1130 949 +19 %
90% died before day: 1247 1079 +16 %
Max lifespan observed (days) 1358 1226
Number of mice at start 54 102
Animal censor events are denoted by + marks in the plot
RaAc16 effect on survival, males, test site = TJL
Log-rank test chisq = 1.9667 p = 0.1608
Wang-Allison test odds ratio = 2.6954 p = 0.0927
Quantiles RaAc16 Control % difference
25% died before day: 468 488 -4 %
Median lifespan (days) 738 748 -1 %
75% died before day: 974 949 +3 %
90% died before day: 1201 1079 +11 %
Max lifespan observed (days) 1309 1226
Number of mice at start 54 102
Animal censor events are denoted by + marks in the plot
UM – female
UM – female      
RaAc9 effect on survival, females, test site = UM
Log-rank test chisq = 12.8312 p = 0.0003
Wang-Allison test odds ratio = 9.4804 p = 0.0003
Quantiles RaAc9 Control % difference
25% died before day: 828 820 +1 %
Median lifespan (days) 972 902 +8 %
75% died before day: 1144 1000 +14 %
90% died before day: 1221 1098 +11 %
Max lifespan observed (days) 1279 1221
Number of mice at start 44 90
Animal censor events are denoted by + marks in the plot
RaAc16 effect on survival, females, test site = UM
Log-rank test chisq = 6.1499 p = 0.0131
Wang-Allison test odds ratio = 4.4419 p = 0.0129
Quantiles RaAc16 Control % difference
25% died before day: 798 820 -3 %
Median lifespan (days) 943 902 +5 %
75% died before day: 1100 1000 +10 %
90% died before day: 1229 1098 +12 %
Max lifespan observed (days) 1283 1221
Number of mice at start 43 90
Animal censor events are denoted by + marks in the plot
UM – male
UM – male      
RaAc9 effect on survival, males, test site = UM
Log-rank test chisq = 27.9335 p < 0.0001
Wang-Allison test odds ratio = 14.0389 p < 0.0001
Quantiles RaAc9 Control % difference
25% died before day: 872 468 +86 %
Median lifespan (days) 986 790 +25 %
75% died before day: 1161 933 +24 %
90% died before day: 1274 1019 +25 %
Max lifespan observed (days) 1389 1233
Number of mice at start 48 88
Animal censor events are denoted by + marks in the plot
RaAc16 effect on survival, males, test site = UM
Log-rank test chisq = 3.047 p = 0.0809
Wang-Allison test odds ratio = 4.3495 p = 0.0183
Quantiles RaAc16 Control % difference
25% died before day: 543 468 +16 %
Median lifespan (days) 809 790 +2 %
75% died before day: 986 933 +6 %
90% died before day: 1226 1019 +20 %
Max lifespan observed (days) 1254 1233
Number of mice at start 33 88
Animal censor events are denoted by + marks in the plot
UT – female
UT – female      
RaAc9 effect on survival, females, test site = UT
Log-rank test chisq = 71.2212 p < 0.0001
Wang-Allison test odds ratio = NaN p < 0.0001
Quantiles RaAc9 Control % difference
25% died before day: 1003 696 +44 %
Median lifespan (days) 1130 824 +37 %
75% died before day: 1228 937 +31 %
90% died before day: 1250 993 +26 %
Max lifespan observed (days) 1315 1198
Number of mice at start 42 90
Animal censor events are denoted by + marks in the plot
RaAc16 effect on survival, females, test site = UT
Log-rank test chisq = 25.8495 p < 0.0001
Wang-Allison test odds ratio = 37.4802 p < 0.0001
Quantiles RaAc16 Control % difference
25% died before day: 842 696 +21 %
Median lifespan (days) 976 824 +18 %
75% died before day: 1168 937 +25 %
90% died before day: 1209 993 +22 %
Max lifespan observed (days) 1229 1198
Number of mice at start 43 90
Animal censor events are denoted by + marks in the plot
UT – male
UT – male      
RaAc9 effect on survival, males, test site = UT
Log-rank test chisq = 40.3599 p < 0.0001
Wang-Allison test odds ratio = 34.7437 p < 0.0001
Quantiles RaAc9 Control % difference
25% died before day: 750 400 +88 %
Median lifespan (days) 1014 676 +50 %
75% died before day: 1202 825 +46 %
90% died before day: 1277 963 +33 %
Max lifespan observed (days) 1385 1258
Number of mice at start 51 95
Animal censor events are denoted by + marks in the plot
RaAc16 effect on survival, males, test site = UT
Log-rank test chisq = 21.6984 p < 0.0001
Wang-Allison test odds ratio = 4.3413 p = 0.0097
Quantiles RaAc16 Control % difference
25% died before day: 638 400 +60 %
Median lifespan (days) 897 676 +33 %
75% died before day: 1062 825 +29 %
90% died before day: 1195 963 +24 %
Max lifespan observed (days) 1286 1258
Number of mice at start 51 95
Animal censor events are denoted by + marks in the plot


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Statistical definitions