ITP survival analysis:   oxaloacetic acid

Intervention:   oxaloacetic acid     intermediary in oxidative metabolism
Trial code: OAA Dose: 2200 ppm initiated at age: 4 mo Sex: both Cohort: C2007
Results are based on the use of pooled factor(s) that is/are stratified within the survival analysis model.

All test sites combined – female
OAA effect on survival, females, test site = All
Log-rank test chisq = 0.5901 p = 0.4424
Wang-Allison test odds ratio = 1.1574 p = 0.729
Quantiles OAA Control % difference
25% died before day: 774 753 +3 %
Median lifespan (days) 892 865 +3 %
75% died before day: 1016 994 +2 %
90% died before day: 1123 1088 +3 %
Max lifespan observed (days) 1282 1359
Number of mice at start 134 275
Animal censor events are denoted by + marks in the plot
All test sites combined – male
OAA effect on survival, males, test site = All
Log-rank test chisq = 0.6546 p = 0.4185
Wang-Allison test odds ratio = 1.1735 p = 0.6136
Quantiles OAA Control % difference
25% died before day: 609 588 +4 %
Median lifespan (days) 819 784 +4 %
75% died before day: 948 954 -1 %
90% died before day: 1107 1074 +3 %
Max lifespan observed (days) 1324 1247
Number of mice at start 147 276
Animal censor events are denoted by + marks in the plot


By individual test site:

TJL – female
TJL – female      
OAA effect on survival, females, test site = TJL
Log-rank test chisq = 0.6995 p = 0.403
Wang-Allison test odds ratio = 1.6514 p = 0.3802
Quantiles OAA Control % difference
25% died before day: 780 740 +5 %
Median lifespan (days) 946 860 +10 %
75% died before day: 1018 1016 0 %
90% died before day: 1177 1111 +6 %
Max lifespan observed (days) 1243 1340
Number of mice at start 44 92
Animal censor events are denoted by + marks in the plot
TJL – male
TJL – male      
OAA effect on survival, males, test site = TJL
Log-rank test chisq = 0.6147 p = 0.433
Wang-Allison test odds ratio = 0.4875 p = 0.3722
Quantiles OAA Control % difference
25% died before day: 579 569 +2 %
Median lifespan (days) 749 728 +3 %
75% died before day: 899 923 -3 %
90% died before day: 977 1039 -6 %
Max lifespan observed (days) 1098 1200
Number of mice at start 51 87
Animal censor events are denoted by + marks in the plot
UM – female
UM – female      
OAA effect on survival, females, test site = UM
Log-rank test chisq = 0.5912 p = 0.442
Wang-Allison test odds ratio = 1.1102 p = 1.0
Quantiles OAA Control % difference
25% died before day: 790 767 +3 %
Median lifespan (days) 926 900 +3 %
75% died before day: 1040 999 +4 %
90% died before day: 1126 1114 +1 %
Max lifespan observed (days) 1282 1359
Number of mice at start 46 91
Animal censor events are denoted by + marks in the plot
UM – male
UM – male      
OAA effect on survival, males, test site = UM
Log-rank test chisq = 2.4576 p = 0.117
Wang-Allison test odds ratio = 2.8431 p = 0.0757
Quantiles OAA Control % difference
25% died before day: 650 659 -1 %
Median lifespan (days) 841 793 +6 %
75% died before day: 1023 953 +7 %
90% died before day: 1161 1076 +8 %
Max lifespan observed (days) 1263 1191
Number of mice at start 48 93
Animal censor events are denoted by + marks in the plot
UT – female
UT – female      
OAA effect on survival, females, test site = UT
Log-rank test chisq = 0.0896 p = 0.7646
Wang-Allison test odds ratio = 0.8211 p = 1.0
Quantiles OAA Control % difference
25% died before day: 692 756 -8 %
Median lifespan (days) 836 840 0 %
75% died before day: 956 962 -1 %
90% died before day: 1034 1045 -1 %
Max lifespan observed (days) 1135 1261
Number of mice at start 44 92
Animal censor events are denoted by + marks in the plot
UT – male
UT – male      
OAA effect on survival, males, test site = UT
Log-rank test chisq = 0.3342 p = 0.5632
Wang-Allison test odds ratio = 1.0 p = 1.0
Quantiles OAA Control % difference
25% died before day: 620 584 +6 %
Median lifespan (days) 848 810 +5 %
75% died before day: 982 1010 -3 %
90% died before day: 1112 1132 -2 %
Max lifespan observed (days) 1324 1247
Number of mice at start 48 96
Animal censor events are denoted by + marks in the plot


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Statistical definitions