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ITP survival analysis:   INT-767 FXR/TGR5 agonist

Intervention:   INT-767 FXR/TGR5 agonist     bile acid analog, FXR and TGR5 agonist
Trial code: INT-767 Dose: 180 ppm initiated at age: 10 mo Sex: both Cohort: C2012
Results are based on the use of pooled factor(s) that is/are stratified within the survival analysis model.

All test sites combined – female
INT-767 effect on survival, females, test site = All
Log-rank test chisq = 0.0988 p = 0.7533
Wang-Allison test odds ratio = 1.4387 p = 0.2999
Quantiles INT-767 Control % difference
25% died before day: 774 770 +1 %
Median lifespan (days) 868 877 -1 %
75% died before day: 996 1006 -1 %
90% died before day: 1102 1100 0 %
Max lifespan observed (days) 1296 1301
Number of mice at start 136 279
Animal censor events are denoted by + marks in the plot
All test sites combined – male
INT-767 effect on survival, males, test site = All
Log-rank test chisq = 2.5347 p = 0.1114
Wang-Allison test odds ratio = 0.6158 p = 0.2397
Quantiles INT-767 Control % difference
25% died before day: 647 620 +4 %
Median lifespan (days) 791 816 -3 %
75% died before day: 900 960 -6 %
90% died before day: 1012 1055 -4 %
Max lifespan observed (days) 1219 1260
Number of mice at start 147 284
Animal censor events are denoted by + marks in the plot


By individual test site:

TJL – female
TJL – female      
INT-767 effect on survival, females, test site = TJL
Log-rank test chisq = 0.0117 p = 0.9138
Wang-Allison test odds ratio = 1.8693 p = 0.2594
Quantiles INT-767 Control % difference
25% died before day: 782 801 -2 %
Median lifespan (days) 882 924 -5 %
75% died before day: 1006 1014 -1 %
90% died before day: 1158 1092 +6 %
Max lifespan observed (days) 1296 1301
Number of mice at start 48 96
Animal censor events are denoted by + marks in the plot
TJL – male
TJL – male      
INT-767 effect on survival, males, test site = TJL
Log-rank test chisq = 3.625 p = 0.0569
Wang-Allison test odds ratio = 0.8359 p = 1.0
Quantiles INT-767 Control % difference
25% died before day: 590 624 -5 %
Median lifespan (days) 751 844 -11 %
75% died before day: 863 960 -10 %
90% died before day: 992 1006 -1 %
Max lifespan observed (days) 1086 1163
Number of mice at start 54 101
Animal censor events are denoted by + marks in the plot
UM – female
UM – female      
INT-767 effect on survival, females, test site = UM
Log-rank test chisq = 0.1672 p = 0.6826
Wang-Allison test odds ratio = 1.8182 p = 0.357
Quantiles INT-767 Control % difference
25% died before day: 790 745 +6 %
Median lifespan (days) 870 843 +3 %
75% died before day: 1016 988 +3 %
90% died before day: 1091 1084 +1 %
Max lifespan observed (days) 1124 1243
Number of mice at start 44 90
Animal censor events are denoted by + marks in the plot
UM – male
UM – male      
INT-767 effect on survival, males, test site = UM
Log-rank test chisq = 0.1266 p = 0.722
Wang-Allison test odds ratio = 0.5716 p = 0.5415
Quantiles INT-767 Control % difference
25% died before day: 757 719 +5 %
Median lifespan (days) 898 872 +3 %
75% died before day: 1004 1022 -2 %
90% died before day: 1045 1111 -6 %
Max lifespan observed (days) 1219 1204
Number of mice at start 42 84
Animal censor events are denoted by + marks in the plot
UT – female
UT – female      
INT-767 effect on survival, females, test site = UT
Log-rank test chisq = 0.7668 p = 0.3812
Wang-Allison test odds ratio = 0.8311 p = 1.0
Quantiles INT-767 Control % difference
25% died before day: 769 738 +4 %
Median lifespan (days) 852 873 -2 %
75% died before day: 963 1008 -4 %
90% died before day: 1115 1116 0 %
Max lifespan observed (days) 1172 1255
Number of mice at start 44 93
Animal censor events are denoted by + marks in the plot
UT – male
UT – male      
INT-767 effect on survival, males, test site = UT
Log-rank test chisq = 1.3033 p = 0.2536
Wang-Allison test odds ratio = 0.4552 p = 0.2666
Quantiles INT-767 Control % difference
25% died before day: 585 577 +1 %
Median lifespan (days) 770 751 +3 %
75% died before day: 840 886 -5 %
90% died before day: 902 994 -9 %
Max lifespan observed (days) 1061 1260
Number of mice at start 51 99
Animal censor events are denoted by + marks in the plot


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Statistical definitions