ITP survival analysis:   captopril

Intervention:   captopril     antihypertensive agent, anti-aging
Trial code: Capt Dose: 180 ppm initiated at age: 5 mo Sex: both Cohort: C2017
This compound had a significant effect on survival:   females p = 0.002; males p = 0.001

Results are based on the use of pooled factor(s) that is/are stratified within the survival analysis model.

All test sites combined – female
Capt effect on survival, females, test site = All
Log-rank test chisq = 9.58 p = 0.002
Wang-Allison test odds ratio = 2.2922 p = 0.0141
Quantiles Capt Control % difference
25% died before day: 775 767 +1 %
Median lifespan (days) 915 868 +5 %
75% died before day: 1017 958 +6 %
90% died before day: 1144 1060 +8 %
Max lifespan observed (days) 1316 1221
Number of mice at start 132 276
Animal censor events are denoted by + marks in the plot
All test sites combined – male
Capt effect on survival, males, test site = All
Log-rank test chisq = 10.827 p = 0.001
Wang-Allison test odds ratio = 2.1609 p = 0.0195
Quantiles Capt Control % difference
25% died before day: 671 447 +50 %
Median lifespan (days) 820 718 +14 %
75% died before day: 964 919 +5 %
90% died before day: 1094 1029 +6 %
Max lifespan observed (days) 1348 1258
Number of mice at start 150 285
Animal censor events are denoted by + marks in the plot


By individual test site:

TJL – female
TJL – female      
Capt effect on survival, females, test site = TJL
Log-rank test chisq = 8.6824 p = 0.0032
Wang-Allison test odds ratio = 4.7308 p = 0.0072
Quantiles Capt Control % difference
25% died before day: 836 760 +10 %
Median lifespan (days) 960 870 +10 %
75% died before day: 1015 968 +5 %
90% died before day: 1245 1068 +17 %
Max lifespan observed (days) 1316 1209
Number of mice at start 48 96
Animal censor events are denoted by + marks in the plot
TJL – male
TJL – male      
Capt effect on survival, males, test site = TJL
Log-rank test chisq = 1.4024 p = 0.2363
Wang-Allison test odds ratio = 1.1489 p = 0.7876
Quantiles Capt Control % difference
25% died before day: 697 488 +43 %
Median lifespan (days) 827 748 +11 %
75% died before day: 964 949 +2 %
90% died before day: 1081 1079 0 %
Max lifespan observed (days) 1249 1226
Number of mice at start 54 102
Animal censor events are denoted by + marks in the plot
UM – female
UM – female      
Capt effect on survival, females, test site = UM
Log-rank test chisq = 0.0077 p = 0.9303
Wang-Allison test odds ratio = 0.8013 p = 1.0
Quantiles Capt Control % difference
25% died before day: 764 820 -7 %
Median lifespan (days) 890 902 -1 %
75% died before day: 1017 1000 +2 %
90% died before day: 1086 1098 -1 %
Max lifespan observed (days) 1199 1221
Number of mice at start 44 90
Animal censor events are denoted by + marks in the plot
UM – male
UM – male      
Capt effect on survival, males, test site = UM
Log-rank test chisq = 0.1457 p = 0.7027
Wang-Allison test odds ratio = 2.1185 p = 0.2327
Quantiles Capt Control % difference
25% died before day: 484 468 +3 %
Median lifespan (days) 744 790 -6 %
75% died before day: 881 933 -6 %
90% died before day: 1099 1019 +8 %
Max lifespan observed (days) 1250 1233
Number of mice at start 45 88
Animal censor events are denoted by + marks in the plot
UT – female
UT – female      
Capt effect on survival, females, test site = UT
Log-rank test chisq = 5.8882 p = 0.0152
Wang-Allison test odds ratio = 2.9413 p = 0.1085
Quantiles Capt Control % difference
25% died before day: 756 696 +9 %
Median lifespan (days) 872 824 +6 %
75% died before day: 1017 937 +9 %
90% died before day: 1089 993 +10 %
Max lifespan observed (days) 1202 1198
Number of mice at start 40 90
Animal censor events are denoted by + marks in the plot
UT – male
UT – male      
Capt effect on survival, males, test site = UT
Log-rank test chisq = 16.2544 p < 0.0001
Wang-Allison test odds ratio = 4.3413 p = 0.0097
Quantiles Capt Control % difference
25% died before day: 701 400 +75 %
Median lifespan (days) 866 676 +28 %
75% died before day: 1037 825 +26 %
90% died before day: 1125 963 +17 %
Max lifespan observed (days) 1348 1258
Number of mice at start 51 95
Animal censor events are denoted by + marks in the plot


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Statistical definitions