ITP survival analysis:   17-a-estradiol

Intervention:   17-a-estradiol     non-feminizing steroid, anti-aging
Trial code: 17aE2_hi Dose: 14 ppm initiated at age: 10 mo Sex: both Cohort: C2011
This compound had a significant effect on survival:   males p < 0.0001

Results are based on the use of pooled factor(s) that is/are stratified within the survival analysis model.

All test sites combined – female
17aE2_hi effect on survival, females, test site = All
Log-rank test chisq = 0.0009 p = 0.9763
Wang-Allison test odds ratio = 0.8918 p = 0.8638
Quantiles 17aE2_hi Control % difference
25% died before day: 773 771 0 %
Median lifespan (days) 893 873 +2 %
75% died before day: 1007 985 +2 %
90% died before day: 1091 1089 0 %
Max lifespan observed (days) 1252 1456
Number of mice at start 135 281
Animal censor events are denoted by + marks in the plot
All test sites combined – male
17aE2_hi effect on survival, males, test site = All
Log-rank test chisq = 36.5057 p < 0.0001
Wang-Allison test odds ratio = 4.3647 p < 0.0001
Quantiles 17aE2_hi Control % difference
25% died before day: 755 595 +27 %
Median lifespan (days) 918 783 +17 %
75% died before day: 1086 921 +18 %
90% died before day: 1211 1057 +15 %
Max lifespan observed (days) 1375 1258
Number of mice at start 144 294
Animal censor events are denoted by + marks in the plot


By individual test site:

TJL – female
TJL – female      
17aE2_hi effect on survival, females, test site = TJL
Log-rank test chisq = 0.7434 p = 0.3886
Wang-Allison test odds ratio = 0.4633 p = 0.3862
Quantiles 17aE2_hi Control % difference
25% died before day: 829 788 +5 %
Median lifespan (days) 872 892 -2 %
75% died before day: 986 1015 -3 %
90% died before day: 1065 1106 -4 %
Max lifespan observed (days) 1159 1267
Number of mice at start 48 95
Animal censor events are denoted by + marks in the plot
TJL – male
TJL – male      
17aE2_hi effect on survival, males, test site = TJL
Log-rank test chisq = 20.4343 p < 0.0001
Wang-Allison test odds ratio = 10.1882 p < 0.0001
Quantiles 17aE2_hi Control % difference
25% died before day: 769 587 +31 %
Median lifespan (days) 960 763 +26 %
75% died before day: 1162 886 +31 %
90% died before day: 1242 1057 +18 %
Max lifespan observed (days) 1322 1258
Number of mice at start 54 101
Animal censor events are denoted by + marks in the plot
UM – female
UM – female      
17aE2_hi effect on survival, females, test site = UM
Log-rank test chisq = 0.1021 p = 0.7494
Wang-Allison test odds ratio = 1.7556 p = 0.3657
Quantiles 17aE2_hi Control % difference
25% died before day: 716 750 -5 %
Median lifespan (days) 835 872 -4 %
75% died before day: 1011 979 +3 %
90% died before day: 1122 1081 +4 %
Max lifespan observed (days) 1252 1456
Number of mice at start 43 95
Animal censor events are denoted by + marks in the plot
UM – male
UM – male      
17aE2_hi effect on survival, males, test site = UM
Log-rank test chisq = 8.5479 p = 0.0035
Wang-Allison test odds ratio = 3.3191 p = 0.0366
Quantiles 17aE2_hi Control % difference
25% died before day: 797 712 +12 %
Median lifespan (days) 940 860 +9 %
75% died before day: 1150 983 +17 %
90% died before day: 1211 1121 +8 %
Max lifespan observed (days) 1363 1251
Number of mice at start 43 94
Animal censor events are denoted by + marks in the plot
UT – female
UT – female      
17aE2_hi effect on survival, females, test site = UT
Log-rank test chisq = 1.2091 p = 0.2715
Wang-Allison test odds ratio = 0.8113 p = 1.0
Quantiles 17aE2_hi Control % difference
25% died before day: 840 754 +11 %
Median lifespan (days) 942 857 +10 %
75% died before day: 1010 977 +3 %
90% died before day: 1087 1089 0 %
Max lifespan observed (days) 1190 1301
Number of mice at start 44 91
Animal censor events are denoted by + marks in the plot
UT – male
UT – male      
17aE2_hi effect on survival, males, test site = UT
Log-rank test chisq = 8.9808 p = 0.0027
Wang-Allison test odds ratio = 2.6756 p = 0.0816
Quantiles 17aE2_hi Control % difference
25% died before day: 689 542 +27 %
Median lifespan (days) 876 715 +23 %
75% died before day: 1002 857 +17 %
90% died before day: 1094 1013 +8 %
Max lifespan observed (days) 1375 1186
Number of mice at start 47 99
Animal censor events are denoted by + marks in the plot


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Statistical definitions