ITP phenotypes:   body weight     metformin

Trial code: Met Dose: 1000 ppm   initiated at age: 9 mo Sex: f Cohort: C2011
Trial code: Met Dose: 1000 ppm   initiated at age: 9 mo Sex: m Cohort: C2011
The plots below show the means with ± SEM error bars





ANOVA

Factor Df Sum Sq Mean Sq F value Pr(>F)
group 1 28.8606 28.8606 0.1995 0.6552
time 3 32361.7936 10787.2645 74.5626 < 0.0001
group:time 3 275.4259 91.8086 0.6346 0.5927
Residuals 1592 230320.8389 144.6739 NA NA


Means

group time mean SE
Control time_m12 39.0436 0.5318
Control time_m18 42.8495 0.609
Control time_m24 41.7939 0.6595
Control time_m6 31.3862 1.2574
Met time_m12 39.3577 0.6793
Met time_m18 43.1815 0.8099
Met time_m24 39.8898 0.799
Met time_m6 30.8594 0.5243


Pairwise comparisons (Tukey multiple-test correction)

contrast time estimate SE df t.ratio p.value
Control - Met time_m6 0.5269 1.2863 1592 0.4096 0.6822
Control - Met time_m12 -0.3142 1.2341 1592 -0.2546 0.7991
Control - Met time_m18 -0.332 1.2581 1592 -0.2639 0.7919
Control - Met time_m24 1.9041 1.361 1592 1.399 0.162










ANOVA

Factor Df Sum Sq Mean Sq F value Pr(>F)
group 1 483.6569 483.6569 13.0517 0.0003
time 3 11299.3072 3766.4357 101.6386 < 0.0001
group:time 3 313.8403 104.6134 2.823 0.0376
Residuals 1448 53658.7133 37.0571 NA NA


Means

group time mean SE
Control time_m12 45.1358 0.3568
Control time_m18 44.6654 0.401
Control time_m24 40.5988 0.5568
Control time_m6 39.2211 0.3751
Met time_m12 46.1841 0.4558
Met time_m18 46.991 0.4802
Met time_m24 43.0031 0.6394
Met time_m6 39.2639 0.4814


Pairwise comparisons (Tukey multiple-test correction)

contrast time estimate SE df t.ratio p.value
Control - Met time_m6 -0.0429 0.6278 1448 -0.0683 0.9456
Control - Met time_m12 -1.0483 0.6232 1448 -1.6821 0.0928
Control - Met time_m18 -2.3256 0.6783 1448 -3.4285 0.0006
Control - Met time_m24 -2.4043 0.778 1448 -3.0904 0.002










See our ITP data portal page for more information on National Institute on Aging's Interventions Testing Program (ITP) including bibliography, data set downloads, and links to all available hosted data.