ITP phenotypes:   grip strength     acarbose

Trial code: ACA_mid Dose: 1000 ppm   initiated at age: 4 mo Sex: f Cohort: C2013
Trial code: ACA_mid Dose: 1000 ppm   initiated at age: 4 mo Sex: m Cohort: C2013
The plots below show the means with ± SEM error bars





Forelimbs — Females

ANOVA

Factor Df Sum Sq Mean Sq F value Pr(>F)
group 2 2800.2081 1400.1041 6.2986 0.003
Residuals 71 15782.4967 222.2887 NA NA


Means

group mean SE
Old_ACA_mid 110.0071 2.2912
Old_Control 107.6231 2.813
Young_Control 122.52 4.1897


Pairwise comparisons (Tukey multiple-test correction)

contrast estimate SE df t.ratio p.value
Old_ACA_mid - Old_Control 2.3841 4.0606 71 0.5871 0.8275
Old_ACA_mid - Young_Control -12.5129 4.365 71 -2.8666 0.0149
Old_Control - Young_Control -14.8969 4.4344 71 -3.3594 0.0036




All limbs — Females

ANOVA

Factor Df Sum Sq Mean Sq F value Pr(>F)
group 2 768.9332 384.4666 0.5595 0.574
Residuals 71 48788.6084 687.1635 NA NA


Means

group mean SE
Old_ACA_mid 224.6857 3.682
Old_Control 224.6769 5.2593
Young_Control 231.94 7.3557


Pairwise comparisons (Tukey multiple-test correction)

contrast estimate SE df t.ratio p.value
Old_ACA_mid - Old_Control 0.0088 7.1394 71 0.0012 1
Old_ACA_mid - Young_Control -7.2543 7.6746 71 -0.9452 0.6137
Old_Control - Young_Control -7.2631 7.7966 71 -0.9316 0.6223










Forelimbs — Males

ANOVA

Factor Df Sum Sq Mean Sq F value Pr(>F)
group 2 17942.1066 8971.0533 25.6996 < 0.0001
Residuals 63 21991.6661 349.0741 NA NA


Means

group mean SE
Old_ACA_mid 114.1267 3.1053
Old_Control 128.2933 4.6763
Young_Control 152.2095 4.6317


Pairwise comparisons (Tukey multiple-test correction)

contrast estimate SE df t.ratio p.value
Old_ACA_mid - Old_Control -14.1667 5.9082 63 -2.3978 0.0503
Old_ACA_mid - Young_Control -38.0829 5.3159 63 -7.164 < 0.0001
Old_Control - Young_Control -23.9162 6.3162 63 -3.7865 0.001




All limbs — Males

ANOVA

Factor Df Sum Sq Mean Sq F value Pr(>F)
group 2 24137.9157 12068.9578 18.6211 < 0.0001
Residuals 63 40832.4989 648.1349 NA NA


Means

group mean SE
Old_ACA_mid 269.3 5.3206
Old_Control 253.7067 6.175
Young_Control 303.0381 4.4177


Pairwise comparisons (Tukey multiple-test correction)

contrast estimate SE df t.ratio p.value
Old_ACA_mid - Old_Control 15.5933 8.0507 63 1.9369 0.1368
Old_ACA_mid - Young_Control -33.7381 7.2435 63 -4.6577 0.0001
Old_Control - Young_Control -49.3314 8.6065 63 -5.7319 < 0.0001










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